Theory of mind and decision-making processes are impaired in Parkinson's disease

Chen, Xi; Zhu, Yifang; Mu, Yanfang; Chen, Bing; Dong, Bin; Huang, Cheng; Hu, Panpan; Zhu, Chunyan; Wang, Kai

doi:10.1016/j.bbr.2014.11.035

Cited by 45 publications

(61 citation statements)

References 91 publications

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“…In PD affective ToM positively correlated with the total number of advantageous cards in the Iowa Gambling Task, a well-established task to assess decision-making under ambiguity [34]. The ability to infer emotional mental states of others appears then to be linked with the effective use of emotions for appropriate personal judgment in decision-making with possible consequence in social wellbeing.…”

Section: Discussionmentioning

confidence: 97%

Freezing of gait and affective theory of mind in Parkinson disease

Ferrari

Lagravinese

Pelosin

et al. 2015

Parkinsonism & Related Disorders

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Section: Discussionmentioning

confidence: 97%

Freezing of gait and affective theory of mind in Parkinson disease

Ferrari

Lagravinese

Pelosin

et al. 2015

Parkinsonism & Related Disorders

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“…Initial studies with the Iowa Gambling Task (IGT) found it to be sensitive to ventromedial (VM) and OFC functioning, as patients with lesions in these brain regions exhibited deficient IGT scores and difficulties in real-world decision making despite normal range performance on other neuropsychological tests (Bechara, Damasio, Damasio, & Lee, 1999). Subsequent functional imaging research has confirmed a connection between IGT performance and VM/OFC function (Li, F I G U R E 6 Whole-brain activation map by GLM analysis a) when FRN amplitude performed as a regressor, b) when alpha-band power performed as a regressor, c) when theta-band power performed as a regressor for monetary wins compared to losses significantly more risky decision-making patterns in Parkinson's disease (PD) patients than in healthy controls (Xi et al, 2015). Those potential impairments have been explained by dysfunctional activity in the frontostriatal network and, more precisely, the orbitofrontal-ventrostriatal pathway (Michele & Ubaldo, 2012) which is considered to regulate motivational, that is, reward-related processes.…”

Section: Discussionmentioning

confidence: 73%

“…Subsequent functional imaging research has confirmed a connection between IGT performance and VM/OFC function (Li, Zhong‐Lin, D'Argembeau, Ng, & Bechara, ). Several studies observed significantly more risky decision‐making patterns in Parkinson's disease (PD) patients than in healthy controls (Xi et al., ). Those potential impairments have been explained by dysfunctional activity in the frontostriatal network and, more precisely, the orbitofrontal–ventrostriatal pathway (Michele & Ubaldo, ) which is considered to regulate motivational, that is, reward‐related processes.…”

Section: Discussionmentioning

confidence: 99%

Single‐trial EEG‐informed fMRI analysis of emotional decision problems in hot executive function

Guo

Zhou

et al. 2017

Brain and Behavior

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BackgroundExecutive function refers to conscious control in psychological process which relates to thinking and action. Emotional decision is a part of hot executive function and contains emotion and logic elements. As a kind of important social adaptation ability, more and more attention has been paid in recent years.ObjectiveGambling task can be well performed in the study of emotional decision. As fMRI researches focused on gambling task show not completely consistent brain activation regions, this study adopted EEG‐fMRI fusion technology to reveal brain neural activity related with feedback stimuli.MethodsIn this study, an EEG‐informed fMRI analysis was applied to process simultaneous EEG‐fMRI data. First, relative power‐spectrum analysis and K‐means clustering method were performed separately to extract EEG‐fMRI features. Then, Generalized linear models were structured using fMRI data and using different EEG features as regressors.ResultsThe results showed that in the win versus loss stimuli, the activated regions almost covered the caudate, the ventral striatum (VS), the orbital frontal cortex (OFC), and the cingulate. Wide activation areas associated with reward and punishment were revealed by the EEG‐fMRI integration analysis than the conventional fMRI results, such as the posterior cingulate and the OFC. The VS and the medial prefrontal cortex (mPFC) were found when EEG power features were performed as regressors of GLM compared with results entering the amplitudes of feedback‐related negativity (FRN) as regressors. Furthermore, the brain region activation intensity was the strongest when theta‐band power was used as a regressor compared with the other two fusion results.ConclusionsThe EEG‐based fMRI analysis can more accurately depict the whole‐brain activation map and analyze emotional decision problems.

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“…Correlations between social cognition and motor disorder in clinical populations 3.1.1 Parkinson's disease Multiple studies have demonstrated within-sample correlations between motor dysfunction and sociocognitive ability in PD. For example, Xi et al (2015) found that for medicated early to moderate stage PD patients, RMET scores were negatively correlated with disease severity (which is largely based on motor symptom severity). Similarly, Raffo de Ferrari et al 2015found that performance on the RMET was worse in PD patients who showed more evidence of later stage hypokinetic symptoms, such as freezing of gait.…”

Section: Discussionmentioning

confidence: 99%

Emotions in action: The relationship between motor function and social cognition across multiple clinical populations

Eddy

Cook

2018

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Theory of mind and decision-making processes are impaired in Parkinson's disease

Cited by 45 publications

References 91 publications

Freezing of gait and affective theory of mind in Parkinson disease

Freezing of gait and affective theory of mind in Parkinson disease

Single‐trial EEG‐informed fMRI analysis of emotional decision problems in hot executive function

Emotions in action: The relationship between motor function and social cognition across multiple clinical populations

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