Theory of mind impairment in schizophrenia: Meta-analysis

Bora, Emre; Yücel, Murat; Pantelis, Christos

doi:10.1016/j.schres.2008.12.020

Cited by 665 publications

(540 citation statements)

References 48 publications

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“…Schizophrenia patients show significant and stable mentalizing impairments as demonstrated in numerous studies (Harrington et al, 2005, Sprong et al, 2007, Bora et al, 2009). …”

Section: Introductionmentioning

confidence: 88%

“…However, schizophrenia patients without first-rank symptoms also show sense of agency impairments, albeit to a lesser degree (Daprati et al, 1997). The ability to attribute mental states to oneself and other people, mentalizing (or "theory of mind"), allows person to understand, manipulate and predict behaviour (Frith and Corcoran, 1996).Schizophrenia patients show significant and stable mentalizing impairments as demonstrated in numerous studies (Harrington et al, 2005, Sprong et al, 2007, Bora et al, 2009). …”

mentioning

confidence: 99%

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Sense of agency and mentalizing: Dissociation of subdomains of social cognition in patients with schizophrenia

Schimansky

David

Rössler

et al. 2010

Psychiatry Research

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The sense of agency, i.e., the sense that "I am the one who is causing an action", and mentalizing, the ability to understand the mental states of other individuals, are key domains of social cognition. It has been hypothesized that an intact sense of agency is an important precondition for higher-level mentalizing abilities. A substantial body of evidence shows that both processes rely on similar brain areas and are severely impaired in schizophrenia, suggesting a close link between agency and mentalizing. Yet this relationship has not been explicitly tested. We investigated 40 individuals with schizophrenia and 40 healthy controls on an agency and mentalizing task. On the agency task, participants carried out simple mouse movements and judged the partially manipulated visual feedback as either self-or other-generated. On the mentalizing task, participants inferred mental states from pictures that depicted others' eyes ("Reading the mind in the eyes test"). Neuropsychological, psychopathological and social functioning levels were also evaluated. Both sense of agency and mentalizing were impaired in schizophrenia patients compared to healthy controls. However, testing for a relationship revealed no significant correlations between the two processes, either in the schizophrenia or the control group. The present findings demonstrate a dissociation of agency and mentalizing deficits in schizophrenia, suggesting that the multifaceted construct of social cognition consists of independent subdomains in healthy and psychiatrically ill individuals. AbstractThe sense of agency, i.e., the sense that "I am the one who is causing an action", and mentalizing, the ability to understand the mental states of other individuals, are key domains of social cognition. It has been hypothesized that an intact sense of agency is an important precondition for higher-level mentalizing abilities. A substantial body of evidence shows that both processes rely on similar brain areas and are severely impaired in schizophrenia, suggesting a close link between agency andmentalizing. Yet this relationship has not been explicitly tested. We investigated 40 individuals with schizophrenia and 40 healthy controls on an agency and mentalizing task. On the agency task, participants carried out simple mouse movements and judged the partially manipulated visual feedback as either self or other generated. On the mentalizing task, participants inferred mental states from pictures that depicted others' eyes ("Reading the Mind in the Eyes test"). Neuropsychological, psychopathological and social functioning levels were also evaluated.Both sense of agency and mentalizing were impaired in schizophrenics compared to healthy controls.However, testing for a relationship revealed no significant correlations between the two processes, either in the schizophrenia or the control group.The present findings demonstrate a dissociation of agency and mentalizing deficits in schizophrenia,suggesting that the multifaceted construct of social cognition consists of independ...

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“…Schizophrenia patients show significant and stable mentalizing impairments as demonstrated in numerous studies (Harrington et al, 2005, Sprong et al, 2007, Bora et al, 2009). …”

Section: Introductionmentioning

confidence: 88%

mentioning

confidence: 99%

Sense of agency and mentalizing: Dissociation of subdomains of social cognition in patients with schizophrenia

Schimansky

David

Rössler

et al. 2010

Psychiatry Research

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show abstract

“…Meta-analyses indicate that patients with schizophrenia have difficulty understanding the intentions of others from a cartoon panel and inferring the beliefs of others from simple written stories [31,32]. These patients show aberrant neural activation in brain regions associated with mentalizing when they are asked to infer the mental states of others.…”

Section: Mentalizingmentioning

confidence: 99%

Social Cognition, Negative Symptoms and Psychosocial Functioning in Schizophrenia

Madeira¹,

Caldeira²,

Bajouco³

et al. 2016

IJCNMH

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Although functional recovery could be advocated as an achievable treatment goal, many effective interventions for the treatment of psychotic symptoms, such as antipsychotic drugs, may not improve functioning. The last two decades of cognitive and clinical research on schizophrenia were a turning point for the firm acknowledgment of how relevant social cognitive deficits and negative symptoms could be in predicting psychosocial functioning. The relevance of social cognition dysfunction in schizophrenia patients' daily living is now unabated. In fact, social cognition deficits could be the most significant predictor of functionality in patients with schizophrenia, non-redundantly with neurocognition. Emerging evidence suggests that negative symptoms appear to play an indirect role, mediating the relationship between neurocognition and social cognition with functional outcomes. Further explorations of this mediating role of negative symptoms have revealed that motivational deficits appear to be particularly important in explaining the relationship between both neurocognitive and social cognitive dysfunction and functional outcomes in schizophrenia. In this paper we will address the relative contribution of two key constructs-social cognitive deficits and negative symptoms, namely how intertwined they could be in daily life functioning of patients with schizophrenia.

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“…Impairments of the ToM network are confirmed by two meta-analyses (Bora et al, 2009;Sprong et al, 2007) and can be regarded as a trait marker for schizophrenia. In the present study cortical thinning of the temporo-parietal junction has been shown in G72 risk allele carriers.…”

Section: Reduced Cortical Thickness In Risk Carriers and Potential Fumentioning

confidence: 87%

Reduced Cortical Thickness is Associated with the Glutamatergic Regulatory Gene Risk Variant DAOA Arg30Lys in Schizophrenia

Schultz

Nenadić

Koch

et al. 2011

Neuropsychopharmacol

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In light of current etiological concepts the glutamatergic system plays an essential role for the pathophysiology of the disorder, offering multiple options for new treatment strategies. The D-amino oxidase activator (DAOA) gene is closely connected to the glutamatergic system and its therapeutic and pathophysiological relevance for schizophrenia is therefore intensively debated. In a further step to shed light on the role of DAOA in schizophrenia, we aimed to investigate the association of the functional DAOA Arg30Lys (rs2391191) variant and cortical thickness in schizophrenia. Cortical thickness was computed by an automated surface-based technique (FreeSurfer) in 52 genotyped patients with schizophrenia and 42 healthy controls. Cortical thickness of the entire cortex was compared between risk carriers and non-risk carriers regarding the Arg30Lys polymorphism in patients and healthy controls on the basis of a node-by-node procedure and an automated clustering approach. Risk carriers with schizophrenia show significantly thinner cortex in two almost inversely arranged clusters on the left and right hemisphere comprising middle temporal, inferior parietal, and lateral occipital cortical areas. The clusters encompass an area of 1174 mm 2 (left) and 1156 mm 2 (right). No significant effect was observed in healthy controls. The finding of our study that the Arg30Lys risk variant is associated with a distinct cortical thinning provides new evidence for the pathophysiological impact of DAOA in schizophrenia. The affected areas are mostly confined to cortical regions with a crucial role in the ToM network and visual processing, which both can be influenced by glutamatergic modulation. Our finding thus underlines the importance of DAOA and related glutamatergic processes as a putative target for therapeutic interventions in schizophrenia.

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Theory of mind impairment in schizophrenia: Meta-analysis

Cited by 665 publications

References 48 publications

Sense of agency and mentalizing: Dissociation of subdomains of social cognition in patients with schizophrenia

Sense of agency and mentalizing: Dissociation of subdomains of social cognition in patients with schizophrenia

Social Cognition, Negative Symptoms and Psychosocial Functioning in Schizophrenia

Reduced Cortical Thickness is Associated with the Glutamatergic Regulatory Gene Risk Variant DAOA Arg30Lys in Schizophrenia

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