Theory of Mind Impairments in Women With Cocaine Addiction

Sanvicente‐Vieira, Breno; Kluwe-Schiavon, Bruno; Corcoran, Rhiannon; Grassi‐Oliveira, Rodrigo

doi:10.15288/jsad.2017.78.258

Cited by 15 publications

(4 citation statements)

References 62 publications

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“…An auditory version has been created containing trials with and without prosody (276), and multiple versions have been created to help overcome any risk of practice effect (281, 282), which has enabled utilization as an outcome measure in many clinical trials (197, 283–285). Some patient groups exhibit difficulty with the Hinting Task including those with schizophrenia/psychosis (104, 274, 285–296) including ultra high-risk (98) and first-episode (297) samples, groups exhibiting substance misuse (298, 299), and patients with bipolar disorder (264, 300, 301). However, other clinical studies involving patients with first-episode psychosis (302), bipolar disorder (293), or Tourette syndrome (303) revealed no differences to healthy controls.…”

Section: Resultsmentioning

confidence: 99%

What Do You Have in Mind? Measures to Assess Mental State Reasoning in Neuropsychiatric Populations

Eddy

2019

Front. Psychiatry

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Social interaction is closely associated with both functional capacity and well-being. Previous research has not only revealed evidence of social dysfunction in individuals with a wide range of psychiatric and neurological disorders but also generated an abundance of potential measures for assessing social cognition. This review explores the most popular measures used within neuropsychiatric populations to investigate the ability to recognize or reason about the mental states of others. Measures are also critically analyzed in terms of strengths and limitations to aid task selection in future clinical studies. The most frequently applied assessment tools use verbal, visual or audiovisual forms of presentation and assess recognition of mental states from facial features, self-rated empathy, the understanding of other’s cognitive mental states such as beliefs and intentions, or the ability to combine knowledge of other’s thoughts and emotions in order to understand subtle communications or socially inappropriate behavior. Key weaknesses of previous research include limited investigation of relationships with clinical symptoms, and underutilization of measures of everyday social functioning that offer a useful counterpart to traditional “lab” tasks. Future studies should aim to carefully select measures not only based on the range of skills to be assessed but also taking into account potential difficulties with interpretation and the need to gain insight into the application of social cognitive skills as well as ability per se . Some of the best measures include those with well-matched control trials (e.g., Yoni Task) or those that restrict the influence of verbal deficits (e.g., intentions comic strip task), elicit spontaneous mentalizing (e.g., Animations Task), and possess greater ecological validity (e.g., Movie for the Assessment of Social Cognition). Social cognitive research within psychiatric populations will be further enhanced through the development of more closely matched control tasks, and the exploration of relationships between task performance, medication, strategy use, and broader emotional and motor functions.

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Section: Resultsmentioning

confidence: 99%

What Do You Have in Mind? Measures to Assess Mental State Reasoning in Neuropsychiatric Populations

Eddy

2019

Front. Psychiatry

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“…Relatedly, the dmPFC has been implicated in Theory of Mind (ToM), 75 defined as the ability to attribute mental states to oneself and especially to others, 76 a crucial feature in everyday life and social interaction that is impaired in SUD. 77 It is well documented that cocaine dependent individuals show deficits in social-emotional processing. 46 , 78 Our finding that the functional connectivity between dlPFC and dmPFC and vlPFC conveys protection against relapse may speak to the importance of the ability of the ECN, and dlPFC in particular, to regulate negative emotions and broader social-emotional processing necessary for successful outcomes in cocaine use disorder treatment.…”

Section: Discussionmentioning

confidence: 99%

Functional connectivity of dorsolateral prefrontal cortex predicts cocaine relapse: implications for neuromodulation treatment

Zhai

Salmeron

et al. 2021

Brain Communications

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Relapse is one of the most perplexing problems of addiction. The dorsolateral prefrontal cortex is crucially involved in numerous cognitive and affective processes that are implicated in the phenotypes of both substance use disorders and other neuropsychiatric diseases, and has become the principal site to deliver transcranial magnetic stimulation for their treatment. However, the dorsolateral prefrontal cortex is an anatomically large and functionally heterogeneous region, and the specific dorsolateral prefrontal cortex locus and dorsolateral prefrontal cortex-based functional circuits that contribute to drug relapse and/or treatment outcome remain unknown. We systematically investigated the relationship of cocaine relapse with functional circuits from 98 dorsolateral prefrontal cortex regions-of-interest defined by evenly sampling the entire surface of bilateral dorsolateral prefrontal cortex in a cohort of cocaine dependent patients (n = 43, 5 F) following a psychosocial treatment intervention. Cox regression models were utilized to predict relapse likelihood based on dorsolateral prefrontal cortex functional connectivity strength. Functional connectivity from only 3 of the 98 dorsolateral prefrontal cortex loci, one in the left and two in the right hemisphere, significantly predicted cocaine relapse with an accuracy of 83.9%, 84.6% and 85.4%, respectively. Combining all three loci significantly improved prediction validity to 87.5%. Protective and risk circuits related to these dorsolateral prefrontal cortex loci were identified that have previously been implicated to support “bottom up” drive to use drug and “top down” control over behavior together with social emotional, learning and memory processing. Three dorsolateral prefrontal cortex-centric circuits were identified that predict relapse to cocaine use with high accuracy. These functionally distinct dorsolateral prefrontal cortex-based circuits provide insights into the multiple roles played by the dorsolateral prefrontal cortex in cognitive and affective functioning that affects treatment outcome. The identified dorsolateral prefrontal cortex loci may serve as potential neuromodulation targets to be tested in subsequent clinical studies for addiction treatment and as clinically relevant biomarkers of its efficacy.

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“…Negative emotional states caused by drug withdrawal are a key causation of addiction relapse (Koob and Volkow, 2010) as well as one of the major causes of SUD establishment, maintenance and relapse (Koob and Volkow, 2016). Interestingly, the DMPFC has been implicated in Theory of Mind (ToM) (Isoda and Noritake, 2013), defined as the ability to attribute mental states to oneself and especially to others (Premack and Woodruff, 1978), a crucial feature in everyday life and social interaction that is impaired in SUD (Sanvicente-Vieira et al ., 2017). It is well documented that cocaine dependent individuals show deficits in social-emotional processing (Geng et al ., 2017; Preller et al ., 2014).…”

Section: Discussionmentioning

confidence: 99%

Functional connectivity of dorsolateral prefrontal cortex predicts cocaine relapse

Zhai

Salmeron

et al. 2020

Preprint

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BackgroundRelapse is one of the most perplexing problems of addiction. The dorsolateral prefrontal cortex (DLPFC) is crucially involved in numerous cognitive and affective processes that are implicated in phenotypes of addiction, and is one of the most frequently reported brain regions with aberrant functionality in substance use disorders. However, the DLPFC is an anatomically large and functionally heterogeneous region, and the specific DLPFC-based circuits that contribute to drug relapse remain unknown.MethodsWe systematically investigated the relationship of cocaine relapse with 98 DLPFC functional circuits defined by evenly sampling the entire bilateral DLPFC in a cohort of cocaine dependent patients (n=43, 5F) following a psychosocial treatment intervention. A Cox regression model was utilized to predict relapse likelihood based on DLPFC functional connectivity strength.ResultsFunctional connectivity from 3 of the 98 DLPFC loci, one on the left and two on the right hemisphere, significantly predicted cocaine relapse with an accuracy of 83.9%, 84.7% and 85.4%, respectively. Combining all three significantly improved prediction validity to 87.5%. Protective and risk circuits related to these DLPFC loci were identified that are known to support “bottom up” drive to use drug and “top down” control over behavior together with social emotional, learning and memory processing.ConclusionThree DLPFC-centric circuits were identified that predict relapse to cocaine use with high accuracy. These functionally distinct DLPFC-based circuits provide insights into the multiple roles played by the DLPFC in cognitive and affective functioning that affects treatment outcome. The identified DLPFC loci may serve as potential neuromodulation targets for addiction treatment and as clinically relevant biomarkers of its efficacy.

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Theory of Mind Impairments in Women With Cocaine Addiction

Cited by 15 publications

References 62 publications

What Do You Have in Mind? Measures to Assess Mental State Reasoning in Neuropsychiatric Populations

What Do You Have in Mind? Measures to Assess Mental State Reasoning in Neuropsychiatric Populations

Functional connectivity of dorsolateral prefrontal cortex predicts cocaine relapse: implications for neuromodulation treatment

Functional connectivity of dorsolateral prefrontal cortex predicts cocaine relapse

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