2006
DOI: 10.1016/j.imlet.2005.10.003
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Theory of proteolytic antibody occurrence

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Cited by 30 publications
(39 citation statements)
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References 84 publications
(97 reference statements)
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“…There is no papain in our preparations of purified 7D6 Fab fragments, as per intact mass determination and peptide sequencing by MS techniques (data not shown), and neither storage at 4°C nor heating to 95°C inhibits generation of bands Y/Z for any of the Fabs in the panel, nor do mixtures of various kinds of protease inhibitors (data not shown). In particular, serine protease inhibitors do not impact this proteolysis (data not shown), arguing that it is unlikely that this proteolytic activity originates from intrinsic protease activity from the Fab itself; an uncommon but reported activity of some antibodies is that they can possess catalytic protease activity toward the antigens they bind (53), and this activity, when observed, is most often via serine protease activity (54,55). Elucidation of the chemical mechanism behind the specificity of this conditional proteolysis remains a focus of investigation.…”
Section: Discussionmentioning
confidence: 98%
“…There is no papain in our preparations of purified 7D6 Fab fragments, as per intact mass determination and peptide sequencing by MS techniques (data not shown), and neither storage at 4°C nor heating to 95°C inhibits generation of bands Y/Z for any of the Fabs in the panel, nor do mixtures of various kinds of protease inhibitors (data not shown). In particular, serine protease inhibitors do not impact this proteolysis (data not shown), arguing that it is unlikely that this proteolytic activity originates from intrinsic protease activity from the Fab itself; an uncommon but reported activity of some antibodies is that they can possess catalytic protease activity toward the antigens they bind (53), and this activity, when observed, is most often via serine protease activity (54,55). Elucidation of the chemical mechanism behind the specificity of this conditional proteolysis remains a focus of investigation.…”
Section: Discussionmentioning
confidence: 98%
“…Протабзими класу IgG, здатні гідролізувати інтестинальний вазоактивний пептид, було вперше виявлено в сироватці крові хворих на астму [5]. Також було показано, що рівень цих антитіл у сироватці крові позитивно корелює із загостренням хвороби, що вказує на патогенність цих автоантитіл в організмі людини [6]. Вста-новлено, що руйнування певних автоантигенів протабзимами тісно позв'язане з розвитком певних автоімунних захворювань.…”
Section: метою роботи було з'ясувати здатність гістонів спричинювати unclassified
“…Вузька субстратна специфічність робить прот абзими перспективними молекулярними мар-керами у прогнозуванні розвитку автоімунних захворювань. Протеолітично активні антитіла було виявлено в сироватці крові хворих на деякі онкологічні та спадкові захворювання [10,11], a також у частини клінічно здорових людей [3,[12][13][14][15]. Показано, що в нормі протабзими мо-жуть бути залучені в руйнування і видалення з організму низки патогенних протеїнів, задіяних у розвитку вірусних інфекцій [3] і нейродегене-ративних захворювань [12][13][14][15].…”
Section: метою роботи було з'ясувати здатність гістонів спричинювати unclassified
“…Immune processes after immunization of mammals with bacterial DNA, proteins, polysaccharides during many infectious diseases may be considered similar to those after immunization of healthy mice with DNA, different proteins and enzymes. According to theoretical analysis, the adaptive improvement of the catalytic turnover is limited by the rate of B cell receptor signal transduction, as rapid release of antigen fragments from catalytic B cell receptors aborts clonal selection, but production of catalysts can occur at increased levels under conditions of rapid B cell signaling in AI disease (Paul et al, 2006). In addition, the RAs of DNase Abs increased with the progress of the AI pathology, while the time course of immunization associated with some infections is usually not so long as compared with AI diseases, which can have chronic character.…”
Section: Comparison Of the Relative Catalytic Activity Of Abs From DImentioning
confidence: 99%