Theragnostic Gadolinium-Based Nanoparticles Safely Augment X-ray Radiation Effects in Patients with Cervical Cancer

Chargari, Cyrus; Maury, Pauline; Texier, Matthieu; Genestie, Catherine; Morice, Philippe; Bockel, Sophie; Gouy, Sébastien; Ba, Mouhamadou; Achkar, Samir; Lux, François; Tillement, Olivier; Dufort, Sandrine; Duc, Géraldine L.E.; Debeaumont, Olivier; Massard, Christophe; Maulard, Amandine; Porcel, Erika; Bahleda, Ratislav; Ammari, Samy; Morel, Daphné; Espenel, Sophie; Pautier, Patricia; Robert, Charlotte; Deutsch, Eric

doi:10.1021/acsnano.3c12537

ACS Nano

2024

DOI: 10.1021/acsnano.3c12537

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Theragnostic Gadolinium-Based Nanoparticles Safely Augment X-ray Radiation Effects in Patients with Cervical Cancer

Cyrus Chargari,

Pauline Maury,

Matthieu Texier

et al.

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Cited by 6 publications

References 34 publications

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Gold Nanoparticles Cause Radiosensitization in 4T1 Cells by Inhibiting DNA Double Strand Break Repair: Single Cell Comparisons of DSB Formation and γH2AX Expression

Atkinson,

Chopin,

Bezak

et al. 2024

ChemPhysChem

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Metal nanoparticles sensitize cancers to radiotherapy however their mechanisms of action are complex. The conceptual inspiration arose from theories of physical dose deposition but various chemical and biological factors have also been identified. Interpretation of data has been limited by challenges in measuring true DNA damage compared to DNA damage repair factors. Here, we applied a new assay, STRIDE, for the first time to measure DNA double strand breaks (DSBs) in 4T1 cells as a model of triple negative breast cancer exposed to gold nanoparticles and radiation, and compared this to the common γH2AX assay for DSB repair. The STRIDE assay showed no increase in DSB detection 15 mins after irradiation for cells containing nanoparticles compared to cells without. Gold nanoparticles led to prolonged detection of DSBs after irradiation and delayed the DSB repair. The data show no evidence of increased radiation dose deposition with nanoparticles, but rather enhanced radiobiological effects resulting from nanoparticles which includes disruption of the recruitment of essential DDR machinery, thereby impairing DNA repair processes.

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Gold Nanoparticles Cause Radiosensitization in 4T1 Cells by Inhibiting DNA Double Strand Break Repair: Single Cell Comparisons of DSB Formation and γH2AX Expression

Atkinson,

Chopin,

Bezak

et al. 2024

ChemPhysChem

View full text Add to dashboard Cite

show abstract

Nanotheranostics for gynecological cancers: a path forward for Africa

Aza,

Suberu,

Balogun

et al. 2024

Med Oncol

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Use of nanoparticles in radiation oncology

Schick,

Bourbonne,

Lucia

et al. 2024

Cancer/Radiothérapie

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Theragnostic Gadolinium-Based Nanoparticles Safely Augment X-ray Radiation Effects in Patients with Cervical Cancer

Cited by 6 publications

References 34 publications

Gold Nanoparticles Cause Radiosensitization in 4T1 Cells by Inhibiting DNA Double Strand Break Repair: Single Cell Comparisons of DSB Formation and γH2AX Expression

Gold Nanoparticles Cause Radiosensitization in 4T1 Cells by Inhibiting DNA Double Strand Break Repair: Single Cell Comparisons of DSB Formation and γH2AX Expression

Nanotheranostics for gynecological cancers: a path forward for Africa

Use of nanoparticles in radiation oncology

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