Theranostic Applications of Lysozyme-Based Nanoparticles

Das, Sourav; Pabba, Manideep; Dhushyandhun, M. E.; Patra, Chitta Ranjan

doi:10.1007/978-981-13-8954-2_1

Cited by 3 publications

(2 citation statements)

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“…Lysozyme is a biocompatible, 14.3 kDa protein abundant in body fluids. [ 39 ] The uniquely faceted structure of the protein lysozyme makes it useful for providing stability and a shell structure to the nanocomposite. In strongly alkaline medium (pH = 11), the 3D structure of the protein might have been partially unfolded to open various groups (─COOH, ─NH 2 , ─SH) that help to form the nanocomposites.…”

Section: Resultsmentioning

confidence: 99%

Design of Lysozyme‐Templated Biocompatible Fluorescent Nanocomposites and Their Potential Applications for Cell Imaging, Hydrogen Peroxide Sensing, and Cancer Therapy

Das

Tripathy

Sreedhar

et al. 2023

Advanced Therapeutics

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Recently, multifunctional metal‐based nanocomposites gained immense importance in various biomedical applications. Here, a simple approach is reported to synthesize fluorescent bimetallic nanocomposites (NCs) of silver‐gold (Ag@Au NC) and silver‐platinum (Ag@Pt NC) by reducing silver nitrate (AgNO3) on gold nanoparticles and platinum nanoparticles (AuNPs, PtNPs), respectively, in the presence of lysozyme that acts as capping agent. Various in vitro (in normal cells including Chinese hamster ovarian and human umbilical vein endothelial cells) and in vivo (in mouse and chicken egg chorioallantoic membrane model) studies reveal the biocompatibility of these nanocomposites. However, these NCs show inhibition of cancer cell proliferation when treated to various cancer cells (MCF‐7, MDA‐MB‐231, and B16F10), indicating their anticancer property. Intraperitoneal administration of these NCs resulted in the regression of melanoma tumor in C57BL/6J mouse model. Further, these NCs displayed green fluorescence inside MCF‐7 cells facilitating in vitro live‐cell imaging and sense hydrogen peroxide (H2O2) in cellular level (B16F10 and MCF‐7) using their fluorescence enhancement property in presence of H2O2.The results (in vitro and in vivo) altogether demonstrate the promising multifunctional applications of bimetallic nanocomposites (NCs) that can be utilized as promising transformative drugs in cancer theranostics applications.

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Section: Resultsmentioning

confidence: 99%

Design of Lysozyme‐Templated Biocompatible Fluorescent Nanocomposites and Their Potential Applications for Cell Imaging, Hydrogen Peroxide Sensing, and Cancer Therapy

Das

Tripathy

Sreedhar

et al. 2023

Advanced Therapeutics

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“…165-169 Regarding the latter point, the antimicrobial properties and applications of lysozyme protein-based coatings have also been demonstrated in numerous studies. [170][171][172][173][174][175][176] Protein adsorption can also be used to functionalize nanoparticles 177 whereby a layer of proteins is formed on the nanoparticle surface called the protein corona, which alters the biological identity of the nanoparticles. [177][178][179] While this can lead to undesirable immune response such as complement activation, 180 rational pre-coating of protein molecules including BSA, Factor H, clusterin and CD47 onto nanoparticles have been demonstrated…”

Section: Examples Of Functional Protein Coatingsmentioning

confidence: 99%

A materials science framework for connecting protein stability with surface adsorption and coating applications

Junren¹

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Protein-Based Nanocarriers and Nanotherapeutics for Infection and Inflammation

Nagar,

Naidu,

Mishra

et al. 2023

J Pharmacol Exp Ther

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Infectious and inflammatory diseases are one of the leading causes of death globally.The status quo has become more prominent with the onset of Covid-19 pandemic. In order to combat these potential crises, proteins have been proven as highly efficacious drugs, drug targets and biomarkers. On the other hand, advancements in nanotechnology have aided efficient and sustained drug delivery due to their nano-dimension-acquired advantages.Combining both the strategies together, the protein nanoplatforms are equipped with the advantageous intrinsic properties of proteins as well as nanoformulations, eloquently changing the field of nanomedicine. Proteins can act as carriers, therapeutics, diagnostics and theranostic in their nanoform as fusion proteins or as composites with other organic/inorganic materials. Protein-based nanoplatforms have been extensively explored in order to target the major infectious and inflammatory diseases of clinical concern. The current review comprehensively deliberated proteins as nanocarriers for drugs and nanotherapeutics for inflammatory and infectious agents with special emphasis on cancer and viral diseases.Plethora of proteins from diverse organisms have aided in the synthesis of protein based nanoformulations. The current study specifically presented the proteins of human and pathogenic origin, to dwell upon the field of protein nanotechnology emphasizing on their pharmacological advantages. Further, the successful clinical translation and current bottlenecks of the protein-based nanoformulations associated with infection-inflammation paradigm has also been discussed comprehensively.

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Theranostic Applications of Lysozyme-Based Nanoparticles

Cited by 3 publications

References 50 publications

Design of Lysozyme‐Templated Biocompatible Fluorescent Nanocomposites and Their Potential Applications for Cell Imaging, Hydrogen Peroxide Sensing, and Cancer Therapy

Design of Lysozyme‐Templated Biocompatible Fluorescent Nanocomposites and Their Potential Applications for Cell Imaging, Hydrogen Peroxide Sensing, and Cancer Therapy

A materials science framework for connecting protein stability with surface adsorption and coating applications

Protein-Based Nanocarriers and Nanotherapeutics for Infection and Inflammation

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