Theranostic Applications of Nanomaterials for Ophthalmic Applications

Kajaria, Divya; Yashwant, V Pathak; Kevin, Braeckmans

doi:10.51542/ijscia.v2i3.20

Cited by 2 publications

(3 citation statements)

References 84 publications

(95 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, some eye diseases require a prompt diagnosis in order to contain possible damages related to the ongoing pathways involved. Age-related macular degeneration (AMD) is the main cause of vision loss for over-65-year-olds [ 37 ]; this pathology has often been analyzed to improve diagnostic techniques since it has several predisposing factors, and early detection is crucial to avoid degeneration toward blindness [ 140 ]. AMD has an unclear etiology, although oxidative stress is considered one of the main risk factors [ 141 ]; as a matter of fact, clinical studies demonstrated the importance of supplementation with antioxidants in order to slow down the progression of AMD [ 142 , 143 ].…”

Section: Fluorescent Nanosystems In Ocular Applicationmentioning

confidence: 99%

“…The development of these applications has given researchers a new way of diagnosing and treating diseases such as cancer, diabetic retinopathy and age-related macular degeneration [ 37 , 155 ]. Among the major chronic eye diseases, diabetic retinopathy is the most prevalent.…”

Section: Fluorescent Nanosystems In Ocular Applicationmentioning

confidence: 99%

“…Fluorescence is a simple and non-invasive way to track the drug through the eye tissues, and it is also widely used in diagnostics to visualize diseased tissues, lesions and pathological markers. The development of personalized medicine and the need for early intervention in the diagnosis and treatment of specific diseases have promoted the birth and development of a new discipline: theranostics [ 37 ]. It can be defined as the combination of diagnostics with a specific therapeutic treatment.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fluorescent Nanosystems for Drug Tracking and Theranostics: Recent Applications in the Ocular Field

et al. 2022

View full text Add to dashboard Cite

The greatest challenge associated with topical drug delivery for the treatment of diseases affecting the posterior segment of the eye is to overcome the poor bioavailability of the carried molecules. Nanomedicine offers the possibility to overcome obstacles related to physiological mechanisms and ocular barriers by exploiting different ocular routes. Functionalization of nanosystems by fluorescent probes could be a useful strategy to understand the pathway taken by nanocarriers into the ocular globe and to improve the desired targeting accuracy. The application of fluorescence to decorate nanocarrier surfaces or the encapsulation of fluorophore molecules makes the nanosystems a light probe useful in the landscape of diagnostics and theranostics. In this review, a state of the art on ocular routes of administration is reported, with a focus on pathways undertaken after topical application. Numerous studies are reported in the first section, confirming that the use of fluorescent within nanoparticles is already spread for tracking and biodistribution studies. The first section presents fluorescent molecules used for tracking nanosystems’ cellular internalization and permeation of ocular tissues; discussions on the classification of nanosystems according to their nature (lipid-based, polymer-based, metallic-based and protein-based) follows. The following sections are dedicated to diagnostic and theranostic uses, respectively, which represent an innovation in the ocular field obtained by combining dual goals in a single administration system. For its great potential, this application of fluorescent nanoparticles would experience a great development in the near future. Finally, a brief overview is dedicated to the use of fluorescent markers in clinical trials and the market in the ocular field.

show abstract

Section: Fluorescent Nanosystems In Ocular Applicationmentioning

confidence: 99%

Section: Fluorescent Nanosystems In Ocular Applicationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fluorescent Nanosystems for Drug Tracking and Theranostics: Recent Applications in the Ocular Field

et al. 2022

View full text Add to dashboard Cite

show abstract

A Systematic Review on the Potential Applications of Theranostic Nanoparticles in Diabetes and its Associated Complication Diabetic Neuropathy

Patangia,

Bhatta,

Vig

et al. 2024

CNANOM

View full text Add to dashboard Cite

Background: Diabetes neuropathy is a frequent ailment that has a substantial impact on patients by increasing the risk of falls and causing discomfort. The lower extremities are where diabetic neuropathy patients first feel pain. This discomfort could seem like a pinprick, an electric shock, or something else. Objective: Here, we give a comprehensive overview of this quickly developing theranostic appli-cation that includes all relevant imaging, diagnostic, therapeutic, and monitoring elements for the management of diabetes and diabetes neuropathy. Methods: The data for the current study was gathered by searching PubMed and Google Scholar. Several research and review publications from various publishers, including Springer Nature, Bentham Science, PLOS one, MDPI, and ACS Publishing Centre, were evaluated to compile the data. Result: Recent developments in theranostics have shown promise as alternate management ap-proaches for diabetes and ailments linked to diabetes. Numerous nanotechnology-built biosen-sors, including multiwalled carbon nanotubes, copper nanowires, zinc oxide tetrapods, and nano-particle-embedded contact lenses, offer benefits in monitoring diabetic neuropathy. Conclusion: The potency, usability, and dependability of insulin substitutes have been demon-strated by a variety of innovative methods for the management of diabetes, which includes nano-technology approaches using Gene-Based Nanoparticles (siRNA), Liposomes, Exo-somes/Extracellular Vesicles, Neuromodulation, and Inhalable Nanoparticles. Over the past few years, the development of various theranostic nanoparticles for Diabetic neuropathy has experi-enced an unprecedented expansion. Even though much work needs to be done to precisely evalu-ate the genuine benefits provided by these particles, such as issues with nanotoxicity, theranostic nanoparticles will have a significant impact on the field of nanomedicine.

show abstract

Theranostic Applications of Nanomaterials for Ophthalmic Applications

Cited by 2 publications

References 84 publications

Fluorescent Nanosystems for Drug Tracking and Theranostics: Recent Applications in the Ocular Field

Fluorescent Nanosystems for Drug Tracking and Theranostics: Recent Applications in the Ocular Field

A Systematic Review on the Potential Applications of Theranostic Nanoparticles in Diabetes and its Associated Complication Diabetic Neuropathy

Contact Info

Product

Resources

About