Theranostic Applications of Nanoparticle-Mediated Photoactivated Therapies

Sharma, Shalini; Zvyagin, Andrei V.; Roy, Indrajit

doi:10.3390/jnt2030009

Cited by 13 publications

(5 citation statements)

References 99 publications

(120 reference statements)

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“…Proper targeting of NPs can generally be achieved either by binding system stabilizers/targeting vectors to the surface of the NPs (antibodies, polymers, peptides, etc.) or by using the EPR effect (Ballinger 2018;Pratt et al 2016;Sharma et al 2021).…”

Section: The Epr Effect and Other Strategies To Improve The Efficacy ...mentioning

confidence: 99%

Radiolabeled nanomaterials for biomedical applications: radiopharmacy in the era of nanotechnology

Pijeira

Viltres

Kozempel

et al. 2022

EJNMMI radiopharm. chem.

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Background Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. Nanomedicine, a term for the application of nanotechnology in medical and health fields, uses nanoparticles for several applications such as imaging, diagnostic, targeted cancer therapy, drug and gene delivery, tissue engineering, and theranostics. Results Here, we overview the current state-of-the-art of radiolabeled nanoparticles for molecular imaging and radionuclide therapy. Nanostructured radiopharmaceuticals of technetium-99m, copper-64, lutetium-177, and radium-223 are discussed within the scope of this review article. Conclusion Nanoradiopharmaceuticals may lead to better development of theranostics inspired by ingenious delivery and imaging systems. Cancer nano-theranostics have the potential to lead the way to more specific and individualized cancer treatment. Graphical abstract

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Section: The Epr Effect and Other Strategies To Improve The Efficacy ...mentioning

confidence: 99%

Radiolabeled nanomaterials for biomedical applications: radiopharmacy in the era of nanotechnology

Pijeira

Viltres

Kozempel

et al. 2022

EJNMMI radiopharm. chem.

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“…Moreover, simultaneous detection of both the photosensitizing compound and the carrier during the delivery process is readily achieved, for example by labeling the carrier with a spectrally distinct fluorophore [ 68 ]. Despite fluorescence emission is conveniently used for imaging, diverse theranostic constructs can be obtained by combining PSs with species that give other types of diagnostic readouts [ 288 , 289 ]. In spite of their potential, applications of fluorescence imaging techniques with subdiffraction resolution to investigate the interaction of the PS with their targets and the effect of photosensitization on the microbial structure are still just a few.…”

Section: Delivery Of Photosensitizers and Theranostic Formulationsmentioning

confidence: 99%

Photodynamic treatment of pathogens

2022

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The current viral pandemic has highlighted the compelling need for effective and versatile treatments, that can be quickly tuned to tackle new threats, and are robust against mutations. Development of such treatments is made even more urgent in view of the decreasing effectiveness of current antibiotics, that makes microbial infections the next emerging global threat. Photodynamic effect is one such method. It relies on physical processes proceeding from excited states of particular organic molecules, called photosensitizers, generated upon absorption of visible or near infrared light. The excited states of these molecules, tailored to undergo efficient intersystem crossing, interact with molecular oxygen and generate short lived reactive oxygen species (ROS), mostly singlet oxygen. These species are highly cytotoxic through non-specific oxidation reactions and constitute the basis of the treatment. In spite of the apparent simplicity of the principle, the method still has to face important challenges. For instance, the short lifetime of ROS means that the photosensitizer must reach the target within a few tens nanometers, which requires proper molecular engineering at the nanoscale level. Photoactive nanostructures thus engineered should ideally comprise a functionality that turns the system into a theranostic means, for instance, through introduction of fluorophores suitable for nanoscopy. We discuss the principles of the method and the current molecular strategies that have been and still are being explored in antimicrobial and antiviral photodynamic treatment.

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“…PA imaging may allow nanoparticle accumulation to be monitored at a disease site, which can help guide PTT treatment. PA imaging may also enable satellite lesions to be identified 44 , 45 .…”

Section: Introductionmentioning

confidence: 99%

Theranostic Phthalocyanine and Naphthalocyanine Nanoparticles for Photoacoustic Imaging and Photothermal Therapy of Tumors

Tian,

Carrillo-Malani,

Feng

et al. 2024

Nanotheranostics

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Background: Phthalocyanine (PC) and naphthalocyanine (NC) dyes have long garnered interest as theranostic agents for optical imaging and phototherapy due to their near-infrared absorbance, photostability, imaging contrast, and proven safety in clinical trials. Yet, only a small fraction of these dyes has been evaluated as photothermal therapy (PTT) agents for cancer treatment. Methods: Nearly 40 distinct NC and PC dyes were encapsulated within polymeric PEG-PCL micelles via oil-in-water emulsions. The optimal NC/PC-loaded micelle formulations for PTT and photoacoustic (PA) imaging were identified through in vivo and in vitro studies. Results: The most promising candidate, CuNC(Octa)-loaded micelles, demonstrated a strong PA signal with a peak absorbance at ~870 nm, high photothermal efficiency, and photostability. The CuNC(Octa)-loaded micelles exhibited heat generation as good or better than gold nanorods/nanoshells and >10-fold higher photoacoustic signals. Micelle preparation was reproducible/scalable, and the CuNC(Octa)-loaded micelles are highly stable under physiological conditions. The CuNC(Octa)-loaded micelles localize within tumors via enhanced permeability and retention and are readily detectable by PA imaging. In a syngeneic murine tumor model of triple-negative breast cancer, CuNC(Octa)-loaded micelles demonstrate efficient heat generation with PTT, leading to the complete eradication of tumors. Conclusions: CuNC(Octa)-loaded micelles represent a promising theranostic agent for PA imaging and PTT. The ability to utilize conventional ultrasound in combination with PA imaging enables the simultaneous acquisition of information about tumor morphology and micelle accumulation. PTT with CuNC(Octa)-loaded micelles can lead to the complete eradication of highly invasive tumors.

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Theranostic Applications of Nanoparticle-Mediated Photoactivated Therapies

Cited by 13 publications

References 99 publications

Radiolabeled nanomaterials for biomedical applications: radiopharmacy in the era of nanotechnology

Radiolabeled nanomaterials for biomedical applications: radiopharmacy in the era of nanotechnology

Photodynamic treatment of pathogens

Theranostic Phthalocyanine and Naphthalocyanine Nanoparticles for Photoacoustic Imaging and Photothermal Therapy of Tumors

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