2018
DOI: 10.2147/ijn.s147464
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Theranostic pH-sensitive nanoparticles for highly efficient targeted delivery of doxorubicin for breast tumor treatment

Abstract: A multifunctional theranostic nanoplatform integrated with environmental responses has been developed rapidly over the past few years as a novel treatment strategy for several solid tumors. We synthesized pH-sensitive poly(β-thiopropionate) nanoparticles with a supermagnetic core and folic acid (FA) conjugation (FA-doxorubicin-iron oxide nanoparticles [FA-DOX@ IONPs]) to deliver an antineoplastic drug, DOX, for the treatment of folate receptor (FR)-overexpressed breast cancer. In addition to an imaging functio… Show more

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Cited by 54 publications
(21 citation statements)
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“…Over the last two years, the main anticancer drug coupled to IONPs was doxorubicin (DOX) [ 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 ]. This drug can be covalently bound to functionalized IONPs [ 123 ] or establish electrostatic interactions with negatively charged groups present in the magnetic nanocarriers [ 133 ].…”
Section: Drugs Bound To Ionpsmentioning
confidence: 99%
“…Over the last two years, the main anticancer drug coupled to IONPs was doxorubicin (DOX) [ 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 ]. This drug can be covalently bound to functionalized IONPs [ 123 ] or establish electrostatic interactions with negatively charged groups present in the magnetic nanocarriers [ 133 ].…”
Section: Drugs Bound To Ionpsmentioning
confidence: 99%
“…In recent years, breast cancer has attracted increasing attention due to its high morbidity and mortality in women 1,2. As breast cancer presents with high proliferation, invasion, and metastasis, affected patients have low disease-free survival and overall survival rates 3.…”
Section: Introductionmentioning
confidence: 99%
“…As breast cancer presents with high proliferation, invasion, and metastasis, affected patients have low disease-free survival and overall survival rates 3. Traditional therapeutic methods for breast cancer include surgery, chemotherapy, radiation, and hormonal therapy 1. Among these, chemotherapy is widely used and generally accepted by the patients.…”
Section: Introductionmentioning
confidence: 99%
“…On the other hand, some limitations in targeted drug delivery 13 result in severe toxicity to liver, kidney and spleen [13][14][15] , as well as the poor distribution of anti-cancer drugs in tumor site 6,16 . Therefore, several strategies like development of some NP-based platforms for targeted drug delivery have been reported 4,17,18 .…”
mentioning
confidence: 99%