Theranostic Radiolabeled Nanomaterials for Molecular Imaging and potential Immunomodulation Effects

Chan, Yang-Hsiang; Lin, Syue-Liang; Chiang, Huihua Kenny; Lee, Yi Jang; Chuang, Hung‐Yi

doi:10.1007/s40846-022-00715-6

Cited by 4 publications

(3 citation statements)

References 219 publications

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“…This characteristic allows the use of cold atmospheric plasmas (CAP) in biomedical applications without causing harm to biological samples or organs. CAP has been studied for various biomedical purposes such as sterilization, cancer therapy, healing of wound, and regenerative biomedicine [ [35] , [36] , [37] , [38] , [39] ]. CAP is cable of creating a unique environment that can affect organs via chemical as well as physical interactions [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

“…The combination of nanoformulations and CAP has shown promising medication effects against illnesses. In the prior studies, the plasma technique was employed to induce the self-assembly of a nanoformulation that exhibited colloidal stability or facilitated the sterilization of biomedical devices [ 39 , 44 ]. Here, we intended to investigate the biophysical mechanism of CAP in the formulation of the PLTV, IO, and MB mixture, resulting in the self-assembly plasma-enable nano-propeller (PLTV–IO–MB PENPs).…”

Section: Introductionmentioning

confidence: 99%

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Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis

Jheng,

Chiang,

Kang

et al. 2023

Materials Today Bio

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis

Jheng,

Chiang,

Kang

et al. 2023

Materials Today Bio

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“…In the treatment of diseases with drugs, the location, timing, and profile of drug release must be controlled to minimize toxicity and increase the efficacy of the drug. Nanoparticle encapsulation of drugs has emerged as a promising approach in the field of medicine [19]. Nanoparticles, with sizes ranging from 1 to 100 nm, offer advantages such as high drug loading capacity and specific targeting of cells owing to their size-dependent effect and intracellular uptake [20].…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effects of Cumin Extract-Encapsulated Chitosan Nanoparticles on Skeletal Muscle Atrophy and Grip Strength in Streptozotocin-Induced Diabetic Rats

Wu,

Su,

et al. 2023

Antioxidants

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Skeletal muscle atrophy is a disorder characterized by reductions in muscle size and strength. Cumin extract (CE) possesses anti-inflammatory, antioxidant, and hypoglycemic properties. Its pharmaceutical applications are hindered by its low water solubility and by its cytotoxicity when administered at high doses. In this study, we have developed a simplified water distillation method using a rotary evaporator to isolate the active components in cumin seeds. The anti-inflammatory effects of CE and its potential to ameliorate skeletal muscle atrophy in rats with streptozotocin (STZ)-induced diabetes were evaluated. The half-maximal inhibitory concentration (IC50) of CE for cells was 80 μM. By encapsulating CE in chitosan nanoparticles (CECNs), an encapsulation efficacy of 87.1% was achieved with a slow release of 90% of CE after 24 h of culturing, resulting in CECNs with significantly reduced cytotoxicity (IC50, 1.2 mM). Both CE and CECNs significantly reduced the inflammatory response in interleukin (IL)-6 and IL-1β assays. STZ-induced diabetic rats exhibited sustained high blood glucose levels (>16.5 mmol/L), small and damaged pancreatic β islets, and skeletal muscle atrophy. CE and CECN treatments ameliorated skeletal muscle atrophy, recovered muscle fiber striated appearance, increased grip strength, and decreased IL-6 level. Furthermore, CE and CECNs led to a reduction of damage to the pancreas, restoring its morphological phenotype, increasing serum insulin levels, and lowering blood glucose levels in STZ-induced diabetic rats. Taken together, treatment with CECNs over a 6-week period yielded positive ameliorative effects in STZ-induced rats of muscle atrophy.

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Nanoradiopharmaceuticals: An Attractive Concept in Oncotherapy

Hou,

Liu,

2024

ChemMedChem

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Radiopharmaceuticals are of significant importance in the fields of tumor imaging and therapy. In recent decades, the increasing role of nanotechnology has led to the attractive concept of nanoradiopharmaceuticals. Consequently, it is imperative to provide a concise summary of the necessary guidelines to facilitate the translation of nanoradiopharmaceuticals. In this work, we have presented the contents of radiolabeling strategies and some applications of nanoradiopharmaceuticals. Such a framework can assist researchers in identifying more pertinent insights or making more informed decisions in the study of nanoradiopharmaceuticals.

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Theranostic Radiolabeled Nanomaterials for Molecular Imaging and potential Immunomodulation Effects

Cited by 4 publications

References 219 publications

Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis

Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis

Ameliorative Effects of Cumin Extract-Encapsulated Chitosan Nanoparticles on Skeletal Muscle Atrophy and Grip Strength in Streptozotocin-Induced Diabetic Rats

Nanoradiopharmaceuticals: An Attractive Concept in Oncotherapy

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