Theranostic strategies to potentiate glioblastoma treatment via nanotechnology: The example of gold nanoparticles

Peptide-Hitchhiking for the Development of Nanosystems in Glioblastoma

“…In mild HT, the surrounding temperature rises to 42 and 45 °C after stimulation, activating the immune system and inhibiting tumor growth. The increase in temperature can result in the degradation of intracellular proteins triggered by the activation of defective proteins within the cell’s apoptosis pathways. , HT can also enhance cell membrane permeability, potentially improving drug delivery into tumor cells. , Although various sources of HT exist, magnetic fields are the most used in GBM. Magnetic hyperthermia therapy (MHT) is based on the principles of localized HT, which employs NPs and applies an alternating magnetic field (AMF) to generate heat .…”

“…The increase in temperature can result in the degradation of intracellular proteins triggered by the activation of defective proteins within the cell’s apoptosis pathways. 157 , 158 HT can also enhance cell membrane permeability, potentially improving drug delivery into tumor cells. 158 , 159 Although various sources of HT exist, magnetic fields are the most used in GBM.…”

“… 157 , 158 HT can also enhance cell membrane permeability, potentially improving drug delivery into tumor cells. 158 , 159 Although various sources of HT exist, magnetic fields are the most used in GBM. Magnetic hyperthermia therapy (MHT) is based on the principles of localized HT, which employs NPs and applies an alternating magnetic field (AMF) to generate heat.…”