Theranostics Based on Magnetic Nanoparticles and Polymers: Intelligent Design for Efficient Diagnostics and Therapy

Gauger, Andrew J.; Hershberger, Kian K.; Bronstein, Lyudmila M.

doi:10.3389/fchem.2020.00561

Cited by 32 publications

(16 citation statements)

References 49 publications

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“…[1][2][3][4][5][6][7] As such, theranostic molecules are mainly constituted of an imaging unit combined to a therapeutic agent within the same platform. They can be divided into two families: i) nanoparticles and/or macromolecular materials/polymers in which the diagnostic and therapeutic units are adsorbed, conjugated, or aggregated; [8][9][10][11][12][13][14][15][16] ii) dual molecules, incorporating two distinct units (through a covalent bonding) for diagnosis and therapy. [17][18][19][20][21] These multifunctional molecules operate intracellularly and can be activated by external stimuli such as light.…”

Section: Introductionmentioning

confidence: 99%

Modified Indulines: From Dyestuffs to In Vivo Theranostic Agents

Chen

Pascal

Daurat³

et al. 2021

ACS Appl. Mater. Interfaces

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The efficient, versatile and straightforward synthesis of the first N-alkyl analogs of induline 3B (8a and 8b) is reported. Thanks to the introduction of lipophilic substituents and its attractive photophysical properties (far-red emission and production of singlet oxygen), phenazinium 8b can be used as theranostic agent and shows, at very low concentration (100 nM), a remarkable ability to: i) image cells and zebrafish embryos with high quality under both mono (514 nm) and biphotonic (790 and 810 nm) excitations, ii) efficiently and quickly penetrate cancer cells rather than healthy fibroblast, iii) induce a total or almost total cancer cell death in vitro and in vivo after illumination (exc = 540-560 nm). The molecular structure of 8b is based on a triamino-phenazinium core only, with no need for additional components, highlighting the emergence of a minimalistic and versatile class of fluorescent probes for targeted photodynamic cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Modified Indulines: From Dyestuffs to In Vivo Theranostic Agents

Chen

Pascal

Daurat³

et al. 2021

ACS Appl. Mater. Interfaces

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“…[ 46 ] Moreover, precise control over the interactions between the polymeric ligands and MNPs to construct self‐assembled nanocomposites could effectively manipulate their physicochemical and biological characteristics for biomedical applications. [ 61 ] The MNP self‐assemblies also exhibit enhanced MRI capability in cancer detection compared to single MNPs. [ 62 ] Especially, the self‐assembly/disassembly of MNPs that respond to specific external or endogenous stimuli could control payload release at the desired pathological locations with negligible side effects or endow a unique T 2 / T 1 relaxation converting or enhance T 2 ‐weighted MRI via the adjusting of interparticle interaction and distance.…”

Section: Surface Modification Strategies Of Mnps With Organic Ligandsmentioning

confidence: 99%

Functionalization of Magnetic Nanoparticles with Organic Ligands toward Biomedical Applications

Yang

Lee

2021

Advanced NanoBiomed Research

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Functionalization of magnetic nanoparticles (MNPs) with organic ligands to prepare personalized nanomedicine has attracted tremendous attention in biomedical applications. These organic/MNP nanohybrid platforms not only can exert the superparamagnetic property of MNPs for diagnosis imaging and treatment, but are also endowed with the merits of organic ligands for improved tumor‐targeting ability, blood circulation time, and cellular uptake. Flexibly manipulating the interactions between different inorganic ligands and MNPs to establish a single MNP matrix or multiple MNP assemblies presents advanced strategies in controlling their composition and chemical–physical and biological properties for various biomedical applications. Beginning with a brief introduction to a variety of strategies for the efficient functionalization of MNPs with various organic ligands, herein, the recent progress in the development and biomedical applications of the different types of nanoplatforms of organic ligand–mediated MNPs is briefly introduced, including diagnosis, therapy, imaging‐guided therapy, and drug delivery. Finally, the future opportunities and challenges for next‐generation high‐performance organic ligand–functionalized MNP nanoplatforms are also discussed.

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“…The obtained fits from simulations are in good agreement for the whole range of concerned B 0 , except for its strong limit case (B 0 = 5000 mT case in Figure 4g). Least-square minimization fit of time evolution ϕ(t) for the simplest ODE model using function (18) and obtained estimates of characteristic time of magnetic particle alignment for each value of B 0 in the range from 5 µT to 5 T shown in panels (a-g), respectively; and the (h) least-square minimization fit of the characteristic time dependence on magnetic flux density norm τ char (B 0 ) using Equation (19).…”

Section: Characteristic Time Of Magnetic Particle Alignmentmentioning

confidence: 99%

“…Both magnetic alignment and relaxation are important in, for example, magnetic particle contrast imaging and quantification in magnetic resonance and particle imaging [8,9,[13][14][15], electromagnetic hyperthermia [6,7,16,17], theranostics [18][19][20], magnetorelaxometry [10,21,22], and navigation in the geomagnetic field [23][24][25][26][27]. Magnetic particle alignment at the nano-and micro-scale requires a complex approach for simulating a wide range of possible strengths of an acting external magnetic field.…”

Section: Introductionmentioning

confidence: 99%

A Theoretical Analysis of Magnetic Particle Alignment in External Magnetic Fields Affected by Viscosity and Brownian Motion

et al. 2021

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The interaction of an external magnetic field with magnetic objects affects their response and is a fundamental property for many biomedical applications, including magnetic resonance and particle imaging, electromagnetic hyperthermia, and magnetic targeting and separation. Magnetic alignment and relaxation are widely studied in the context of these applications. In this study, we theoretically investigate the alignment dynamics of a rotational magnetic particle as an inverse process to Brownian relaxation. The selected external magnetic flux density ranges from 5μT to 5T. We found that the viscous torque for arbitrary rotating particles with a history term due to the inertia and friction of the surrounding ambient water has a significant effect in strong magnetic fields (range 1–5T). In this range, oscillatory behavior due to the inertial torque of the particle also occurs, and the stochastic Brownian torque diminishes. In contrast, for weak fields (range 5–50μT), the history term of the viscous torque and the inertial torque can be neglected, and the stochastic Brownian torque induced by random collisions of the surrounding fluid molecules becomes dominant. These results contribute to a better understanding of the molecular mechanisms of magnetic particle alignment in external magnetic fields and have important implications in a variety of biomedical applications.

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Theranostics Based on Magnetic Nanoparticles and Polymers: Intelligent Design for Efficient Diagnostics and Therapy

Cited by 32 publications

References 49 publications

Modified Indulines: From Dyestuffs to In Vivo Theranostic Agents

Modified Indulines: From Dyestuffs to In Vivo Theranostic Agents

Functionalization of Magnetic Nanoparticles with Organic Ligands toward Biomedical Applications

A Theoretical Analysis of Magnetic Particle Alignment in External Magnetic Fields Affected by Viscosity and Brownian Motion

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