Therapeutic Abortion by Means of Artificial Hydramnios at the Geneva Maternity Hospital

Sabeti, Sara; Watteville, H. de

doi:10.1002/j.1879-3479.1967.tb00245.x

Cited by 1 publication

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“…The former technique is usually employed after 14 weeks and, though usually successful, needs skill and experience. Recently, however, there have been disquieting reports of several deaths following the intraamniotic injections of hypertonic saline (Wagatsuma, 1965;Cameron and Dayan, 1966;Sabeti and de Watteville, 1967;Frost, 1968;Diggory et al, 1970). The abortifacient paste can be used in early and mid-pregnancy (Lachelin and Burgess, 1968), but is not free from risk, and sudden death from embolism or vagal inhibition has been reported (Dutra et al, 1950;Williams et al, 1955;Karim and Filshie, 1970).…”

Section: Medicalmentioning

confidence: 99%

THE USE OF PROSTAGLANDIN E₂ FOR THERAPEUTIC ABORTION

Karim¹,

Filshie²

1972

BJOG

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Summary: Termination of pregnancy was attempted with intravenous infusion of prostaglandin E2 (5 ug./minute) in 52 consecutive cases. Abortion was successful in 50 of these and complete in 43. There were no serious side-effects. IntroductionThe stimulant action of different prostaglandins on the intact pregnant human uterus has been shown by several investigators (Bygdeman et al., 1968;Embrey, 1969). Prostaglandins E2 and F2a have been successfully used for the induction of labour in women at or near term (Karim, 1969a(Karim, , 1969bKarim et al., 1969Karim et al., , 1970a. Prostaglandin F2a in higher concentrations (50 ,ug./minute) has also been used to stimulate the uterus in the first and second trimesters of pregnancy to induce therapeutic abortion (Karim and Filshie, 1970). In this paper we describe the effects of an intravenous infusion of 5 ,ug. of prostaglandin E2 per minute on the early and midpregnant uterus in 52 women and its usefulness for therapeutic termination of pregnancy in the first and second trimesters.

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