Therapeutic actions of tea phenolic compounds against oxidative stress and inflammation as central mediators in the development and progression of health problems: A review focusing on microRNA regulation

Liu, Hui; Guan, Hui; He, Fatao; Song, Ye; Li, Feng; Sun‐Waterhouse, Dongxiao; Li, Feng

doi:10.1080/10408398.2023.2202762

Cited by 4 publications

(1 citation statement)

References 338 publications

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“…For instance, catechins can impede the discharge of inflammatory factors (e.g., TNF-𝛼 and IL-1𝛽), thereby diminishing oxidative stress resulting from inflammation (Figure 1a). [32] Considering that inflammatory response triggers the activation of immune cells (e.g., macrophages, neutrophils), these cells generate oxidative substances throughout their activation to exacerbate the degree of oxidative stress. [33] Consequently, restraining excessive activation of immune cells may also mitigate the impacts of oxidative stress.…”

Section: Anti-inflammatory Effectsmentioning

confidence: 99%

Antioxidant Hydrogels: Antioxidant Mechanisms, Design Strategies, and Applications in the Treatment of Oxidative Stress‐Related Diseases

Hu,

Ouyang,

Zhao

et al. 2024

Adv Healthcare Materials

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Oxidative stress is a biochemical process that disrupts the redox balance due to an excess of oxidized substances within the cell. Oxidative stress is closely associated with a multitude of diseases and health issues, including cancer, diabetes, cardiovascular diseases, neurodegenerative disorders, inflammatory conditions, and aging. Therefore, the developing of antioxidant treatment strategies has emerged as a pivotal area of medical research. Hydrogels have garnered considerable attention due to their exceptional biocompatibility, adjustable physicochemical properties, and capabilities for drug delivery. Numerous antioxidant hydrogels have been developed and proven effective in alleviating oxidative stress. In the pursuit of more effective treatments for oxidative stress‐related diseases, there is an urgent need for advanced strategies for the fabrication of multifunctional antioxidant hydrogels. Consequently, our focus will be on hydrogels that possess exceptional reactive oxygen species (ROS) and reactive nitrogen species (RNS) scavenging capabilities, and their role in oxidative stress therapy will be evaluated. Herein, the antioxidant mechanisms and the design strategies of antioxidant hydrogels and their applications in oxidative stress‐related diseases are discussed systematically in order to provide critical insights for further advancements in the field.This article is protected by copyright. All rights reserved

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Section: Anti-inflammatory Effectsmentioning

confidence: 99%

Antioxidant Hydrogels: Antioxidant Mechanisms, Design Strategies, and Applications in the Treatment of Oxidative Stress‐Related Diseases

Hu,

Ouyang,

Zhao

et al. 2024

Adv Healthcare Materials

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Advanced Bionic Technology Combining Online Electrochemistry‐Mass Spectrometry and Offline Electrochemistry‐Liquid Chromatography‐Mass Spectrometry for Simulating and Characterizing Metabolic Processes of Bioactive phenolic acids in Natural Products

Du,

Yang,

et al. 2024

J of Separation Science

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The metabolism research of bioactive phenolic acids widely found in natural products is of great significance for elucidating pharmacologic mechanisms and screening lead compounds. However, it is time‐consuming and vulnerable to interference to conduct the traditional metabolism approach by applying organisms or biomaterials. Herein, a bionic technology was established by combining online electrochemistry‐mass spectrometry (EC‐MS) with offline electrochemistry‐liquid chromatography‐mass spectrometry (EC‐LC‐MS) to investigate the oxidative transformation and metabolic processes of the active phenolic acids (including salvianolic acid A, caffeic acid, 3, 5‐O‐dicaffeoylquinic acid, ferulic acid, salvianic acid A, and protocatechuic acid). Phase I metabolism of the phenolic acids were simulated by applying a three‐electrode controlled potential electrochemical reactor with a boron‐doped diamond electrode, with glutathione mixed into the oxidative products simultaneously for obtaining the phase II metabolites. Finally, structural characterization of the simulated metabolites of the phenolic acids was achieved successfully, including hydroxylation, methylation, demethylation, decarboxylation, etc. It was revealed that the simulated metabolism process based on an electrochemical system was effective in yielding a wide variety of metabolites for these compounds, which was also compared with the metabolism results applying rat liver microsomes. Consequently, this bionic technology is expected to be a powerful tool to investigate the material basis for the efficacy of active ingredients of natural products.

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Redoxification (of the Organism) Through Diet and Supplementation with a Focus on Natural Polymeric Redox Modulators

Sahakyan,

Nasim,

Jacob

2024

Curr. Pharmacol. Rep.

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Therapeutic actions of tea phenolic compounds against oxidative stress and inflammation as central mediators in the development and progression of health problems: A review focusing on microRNA regulation

Cited by 4 publications

References 338 publications

Antioxidant Hydrogels: Antioxidant Mechanisms, Design Strategies, and Applications in the Treatment of Oxidative Stress‐Related Diseases

Antioxidant Hydrogels: Antioxidant Mechanisms, Design Strategies, and Applications in the Treatment of Oxidative Stress‐Related Diseases

Advanced Bionic Technology Combining Online Electrochemistry‐Mass Spectrometry and Offline Electrochemistry‐Liquid Chromatography‐Mass Spectrometry for Simulating and Characterizing Metabolic Processes of Bioactive phenolic acids in Natural Products

Redoxification (of the Organism) Through Diet and Supplementation with a Focus on Natural Polymeric Redox Modulators

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