Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review

Wang, Kailiang; Wong, Joshua K.; Eisinger, Robert S.; Carbunaru, Samuel; Smith, Christine; Hu, Wei; Shukla, Aparna Wagle; Hess, Christopher W.; Okun, Michael S.; Ramirez‐Zamora, Adolfo

doi:10.1111/ner.13220

Cited by 24 publications

(60 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both cases are amongst the few in literature in which an etiology for such tremor is not found. About the conservative pharmacological treatment done by the patient, the literature [4,12] provides data demonstrating that it does not unclear. However, pathway connecting 33,34 GPi-ventrolateral thalamus-motor cortex-Vim-Cerebellum, or GPI-Zona incerta-Vim-cerebellum-motor cortex is supposed to exist.…”

Section: Discussionmentioning

confidence: 99%

“…Th e treatment of HT is diffi cult because of the variable response rates to diff erent therapies (pharmacological or surgical) and the lack of established guideline supported by clinical evidence. Th e fi rst line drugs that can be used are levodopa, levetiracetam (antiepileptic), and trihexyphenidyl (anticholinergic) 4 . Deep brain stimulation (DBS) normally is indicated when the HT is refractory to pharmacological treatment.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Case report of holmes tremor and brief literature review

Martini¹,

Gonzaga²,

Pingarilho³

et al. 2022

jbnc

View full text Add to dashboard Cite

Introduction: Holmes Tremor is a slow frequency tremor, with an irregular presentation of rest and intention tremor, with postural component not obligatory. The Holmes tremor physiopathology, although not completely elucidated, can be explained by lesions in both basal ganglia-thalamo-cortical loop and cerebellum-thalamo cortical loop, and can be treated with a conservative approach– pharmacological treatment – or with surgery. It is reported a case that a surgery was elected as treatment, that resulted in a stimulation of the Ventralis Intermedius (Vim) and Zona Incerta (ZI). Case Presentation: Female patient, 41 years old, with Holmes Tremor involving both upper limbs, more predominant on the right side, and affecting more the proximal than the distal region of the limb. The tremor was both of rest and action, exacerbated by movement, anxiety, and stress. Due to functional impairment and failure of conservative neurological treatment with pharmacotherapy, a neurosurgical procedure was requested for implantation of two electrodes, targeting the Vim and ZI, on the left side for tremor control. Conclusion: Holmes Tremor is a complex syndrome and has its pathophysiology not so well elucidated. The case report describes an implantation of an electrode that had positive outcomes for the patient.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Case report of holmes tremor and brief literature review

Martini¹,

Gonzaga²,

Pingarilho³

et al. 2022

jbnc

View full text Add to dashboard Cite

show abstract

“…Paradoxically, high‐frequency electrical stimulation of the GPi with DBS also provides therapeutic relief in PD 75,76 . Dopaminergic, anticholinergics, and gabaergic neuromodulators have been shown to be effective pharmacological interventions 71,77 . Reduced striatal dopaminergic input has been implicated in a Holmes‐type tremor, which, responded well to cotreatment with the D2 selective agonist pramipexole plus l ‐Dopa 78 .…”

Section: Discussionmentioning

confidence: 99%

A rare case of Holmes tremor in a worker with occupational carbon monoxide poisoning

Rutchik

Bowler

Ratner

2021

American J Industrial Med

View full text Add to dashboard Cite

Parkinsonism and encephalopathy are frequently seen in patients who survive carbon monoxide (CO) poisoning. Neurological findings associated with CO poisoning can emerge immediately after cessation of exposure or following a brief period of pseudo‐recovery. When present, the tremor associated with CO poisoning is typical of the postural/intention type. Here, we report on a rare case of toxic encephalopathy with a dominant‐hand Holmes‐type tremor, characterized by resting, as well as postural and kinetic/intentional components, in a previously healthy 53‐year‐old man exposed to CO while actively engaged in the process of performing a physically demanding skilled labor task. The unique neuropathological and functional changes that give rise to Holmes‐type tremor and how this relates to the selective vulnerability of the inhibitory indirect pathway of the basal ganglia to glutamatergic excitotoxicity mediated by tissue hypoxia are discussed.

show abstract

“…Proper management of post-traumatic tremor is limited by the lack of effectiveness of pharmacological approaches, leading to a growing interest in surgical techniques ( Mendonça et al, 2018 ; Wang et al, 2020 ). Several systematic reviews have been published on a small pool of patients in the literature – fewer than 100 to date – and have found that deep brain stimulation can be an effective therapeutic modality and can provide greater postural tremor suppression compared with medical management ( Rojas-Medina et al, 2016 ; Artusi et al, 2018 ; Wang et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Dual Target Deep Brain Stimulation With Externalized Programming for Post-traumatic Complex Movement Disorder

et al. 2021

View full text Add to dashboard Cite

Introduction: Movement disorders can be common, persistent, and debilitating sequelae of severe traumatic brain injury. Post-traumatic movement disorders are usually complex in nature, involving multiple phenomenological manifestations, and can be difficult to control with medical management alone. Deep brain stimulation (DBS) has been used to treat these challenging cases, but distorted brain anatomy secondary to trauma can complicate effective targeting. In such cases, use of diffusion tractography imaging and inpatient testing with externalized DBS leads can be beneficial in optimizing outcomes.Case Description: We present the case of a 42-year-old man with severe, disabling post-traumatic tremor who underwent bilateral, dual target DBS to the globus pallidus internus (GPi) and a combined ventral intermediate nucleus of the thalamus (Vim)/dentato-rubro-thalamic tracts (DRTT) target. DRTT fiber tracts were reconstructed preoperatively to assist in surgical targeting given the patient’s distorted anatomy. Externalization and survey of the four leads extra-operatively with inpatient testing allowed for internalization of the leads that demonstrated benefit. Six months after surgery, the patient’s tremor and dystonic burden had decreased by 67% in the performance sub-score of The Essential Tremor Rating Scale (TETRAS).Conclusion: A patient-tailored approach including target selection guided by individualized anatomy and tractography as well as extra-operative externalized lead interrogation was shown to be effective in optimizing clinical outcome in a patient with refractory post-traumatic tremor.

show abstract

Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review

Cited by 24 publications

References 37 publications

Case report of holmes tremor and brief literature review

Case report of holmes tremor and brief literature review

A rare case of Holmes tremor in a worker with occupational carbon monoxide poisoning

Case Report: Dual Target Deep Brain Stimulation With Externalized Programming for Post-traumatic Complex Movement Disorder

Contact Info

Product

Resources

About