Therapeutic Agent-Loaded Fibrous Scaffolds for Biomedical Applications

Abstract

Tissue engineering is a sophisticated field that involves the integration of various disciplines, such as clinical medicine, material science, and life science, to repair or regenerate damaged tissues and organs. To achieve the successful regeneration of damaged or diseased tissues, it is necessary to fabricate biomimetic scaffolds that provide structural support to the surrounding cells and tissues. Fibrous scaffolds loaded with therapeutic agents have shown considerable potential in tissue engineering. In this comprehensive review, we examine various methods for fabricating bioactive molecule-loaded fibrous scaffolds, including preparation methods for fibrous scaffolds and drug-loading techniques. Additionally, we delved into the recent biomedical applications of these scaffolds, such as tissue regeneration, inhibition of tumor recurrence, and immunomodulation. The aim of this review is to discuss the latest research trends in fibrous scaffold manufacturing methods, materials, drug-loading methods with parameter information, and therapeutic applications with the goal of contributing to the development of new technologies or improvements to existing ones.

Empowering Precision Medicine: The Impact of 3D Printing on Personalized Therapeutic

“…Moreover, the potential interactions between drug molecules and the printing process itself, such as exposure to high temperatures or shear forces, may impact the stability or activity of the therapeutic agents. Thus, further research is imperative to optimize the formulation and printing parameters to ensure the integrity and efficacy of the incorporated agents [98]. Moreover, the regulatory considerations and approval processes for 3D-printed drug delivery systems present formidable challenges.…”