Therapeutic and Antioxidant Effects of Medicinal Herb “Curcumin” on Formaldehyde- Induced Neurotoxicity in Rats

Abstract

Our problem is to evaluate the behavioral effects of formaldehyde on the anxiety and cognitive abilities of Wistar rats on the one hand, on the other hand, we have proven the protective effect of an antioxidant, “curcumin”. The positive antidepressant and anti-anxiety effects of curcumin are most likely due to its ability to normalize specific physiological mechanisms, in addition to being a potent antioxidant and anti-inflammatory agent. Curcumin also protects the brain and simultaneously acts on several mechanisms related to depression. It is considered to be the most promising therapeutic target for treating depressive behavior. 25 male rats weighing approximately 240 g were divided into equal five groups, toxicity was induced by a single intraperitoneal injection of formaldehyde at a dose of 10 mg/kg. Behavioral test in “light/dark box test” revealed that animals exhibited an anxious behavior when compared to control. The curcumin, was administered orally (gastric gavages) at a dose of 60 mg / kg. The effects of formaldehyde gas on the variation in body weight and an alteration in locomotive and exploratory activities when compared to control. Our results show the therapeutic benefits of curcumin against the deficits caused by formaldehyde reflected in a disturbance in rat behavior.

Effect of Formaldehyde and Curcumin on Histomorphological Indices, Gene Expression Associated with Ovarian Follicular Development, and Total Antioxidant to Oxidant Levels in Wistar Rats

“…FA environmental exposure occurs mostly by inhalation. However, a lot of earlier animal experiments involved indirect exposure techniques such as intraperitoneal and subcutaneous injections [ 3 , 23 ]. In the current study, an intraperitoneal injection was to ensure the same intensity and effect of exposure to FA and further treatment with CUR for associated rats and to minimize the error of the study design.…”