Therapeutic and Biomedical Potentialities of Terpenoids – A Review

Jahangeer, Muhammad; Fatima, Rameen; Ashiq, Mehvish; Basharat, Aneela; Qamar, Sarmad Ahmad; Bilal, Muhammad; Iqbal, Hafiz M.N.

doi:10.22207/jpam.15.2.04

Cited by 37 publications

(20 citation statements)

References 63 publications

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“…Terpenoids and sesquiterpenes are among the main categories of metabolites found in viscum samples. Extensive studies report their antimicrobial, antioxidant, anticonvulsive, analgesic, neuroprotective, anti-inflammatory, anti-allergic, and antitumoral activities [ 51 , 60 , 65 , 66 , 67 , 68 ].…”

Section: Resultsmentioning

confidence: 99%

Romanian Viscum album L.—Untargeted Low-Molecular Metabolomic Approach to Engineered Viscum–AuNPs Carrier Assembly

Segneanu

Marin

Herea

et al. 2022

Plants

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Viscum is one of the most famous and appreciated medicinal plants in Europe and beyond. The symbiotic relationship with the host tree and various endogenous and ecological aspects are the main factors on which the viscum metabolites’ profiles depend. In addition, European traditional medicine mentions that only in two periods of the year (summer solstice and winter solstice) the therapeutic potential of the plant is at its maximum. Many studies have investigated the phytotherapeutic properties of viscum grown on different species of trees. However, studies on Romanian viscum are relatively few and refer mainly to the antioxidant and antiproliferative activity of mistletoe grown on Acer campestre, Fraxinus excelsior, Populus nigra, Malus domestica, or Robinia pseudoacacia. This study reports the first complete low-molecular-weight metabolite profile of Romanian wild-grown European viscum. A total of 140 metabolites were identified under mass spectra (MS) positive mode from 15 secondary metabolite categories: flavonoids, amino acids and peptides, terpenoids, phenolic acids, fatty acids, organic acids, nucleosides, alcohols and esters, amines, coumarins, alkaloids, lignans, steroids, aldehydes, and miscellaneous. In addition, the biological activity of each class of metabolite is discussed. The development of a simple and selective phyto-engineered AuNPs carrier assembly is reported and an evaluation of the nanocarrier system’s morpho-structure is performed, to capitalize on the beneficial properties of viscum and AuNPs.

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Section: Resultsmentioning

confidence: 99%

Romanian Viscum album L.—Untargeted Low-Molecular Metabolomic Approach to Engineered Viscum–AuNPs Carrier Assembly

Segneanu

Marin

Herea

et al. 2022

Plants

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“… 15 In a surge of new therapies from natural sources, terpenoids are found to be effective against NAFLD in several animal models. 16 , 17 This study aimed to assess the anti-NAFLD effect of safranal at two dosing levels in a rat model of HFD. To the best of our knowledge, this is the first study reported by safranal in which we investigated its effect on hepatic lipid accumulation induced by prolonged consumption of a purpose-built diet, as well as its impact on subsequent pathology associated with steatosis, characterized by NASH and fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“… 15 Furthermore, terpenoids have been identified as antioxidant, anti-inflammatory, anti-hyperglycemic, anti-cancer, and immunomodulatory chemical compounds and have been shown to exhibit anti-fatty liver activities. 16 , 17 …”

Section: Introductionmentioning

confidence: 99%

Reduction of Hepatic Steatosis, Oxidative Stress, Inflammation, Ballooning and Insulin Resistance After Therapy with Safranal in NAFLD Animal Model: A New Approach

Sabir¹,

HM²,

Alamgeer³

et al. 2022

JIR

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Introduction Non-alcoholic fatty liver disease (NAFLD) is intimately linked to hepatic steatosis, inflammation, insulin resistance (IR), oxidative stress (OS), and ballooning. A high fat diet (HFD) is considered a major etiological factor that primarily covers the numerous features of NAFLD. Methods The present study aimed to evaluate the protective effect of safranal on hepatic steatosis, OS, liver index, IR index, liver function enzymes, plasma lipids, TNF-α, malondialdehyde (MDA), advanced oxidation protein products (AOPPs) and nitrite (NO 2 – ) levels in a NAFLD rat model fed with a HFD for 12 weeks. The ELISA kits were used to measure TNF-α and insulin in serum and plasma, respectively. Results HFD significantly induced hepatic steatosis, OS, IR, liver, and oxidative enzyme elevation and inflammation in experimental animals. Rats treated with safranal in ascending order of doses 250 and 500 mg/kg orally for 4-weeks showed a reduction in hepatic lipid’s accumulation, liver index, hepatic enzymes, collagen, hepatic oxidonitrative stress markers (like AOPP, MDA and NO 2 – ), and raised the levels of catalase (CAT) and superoxide dismutase (SOD) enzymes. Glutathione system components, namely glutathione (GSH), glutathione peroxidase (GPx), and glutathione-S-transferase (GST) levels were also restored in the safranal-treated groups. The reduction in serum TNF-α and IR provided further support to the anti-NAFLD effect of safranal. Moreover, the histopathological images indicated reverse of NAFLD activity score (NAS) through mild fatty degeneration, ballooning and inflammation in hepatocytes of treated groups. Conclusion Findings of blood and tissue analysis concluded that safranal can be a good choice in the management and cure of NAFLD.

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“…The capitula of tea Chrysanthemum cultivars possess medicinal and economic value rather than aesthetic characteristics. The flowerheads of tea Chrysanthemum mainly produce and emit 3-carene, camphene, eucalyptol, camphor, 2-bornanone and β-selinene, which have the functions of expelling wind and heat, easing anxiety and improving eyesight [ 47 ]. These terpenoids are mainly stored in the glandular trichomes, indicating that the production of volatile terpenes could be increased by increasing the density of glandular trichomes.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Relationship between Trichome and Terpene Chemistry in Chrysanthemum

Guan

Chen

et al. 2022

Plants

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Chrysanthemum is a popular ornamental plant with a long history of cultivation. Both the leaf and flowerhead of Chrysanthemum are known to produce diverse secondary metabolites, particularly terpenoids. Here we aimed to determine the relationship between terpene chemistry and the trichome traits in Chrysanthemum. In our examination of three cultivars of C. morifilium and three accessions of C. indicum, all plants contained T-shaped trichomes and biseriate peltate glandular trichomes. The biseriate peltate glandular trichome contained two basal cells, two stalk cells, six secondary cells and a subcuticular space, while the non-glandular T-shaped trichome was only composed of stalk cells and elongated cells. Histochemical staining analysis indicated that the biseriate peltate glandular trichome contained terpenoids and lipid oil droplets but not the T-shaped trichome. Next, experiments were performed to determine the relationship between the accumulation and emission of the volatile terpenoids and the density of trichomes on the leaves and flowerheads in all six Chrysanthemum cultivars\accessions. A significant correlation was identified between the monoterpenoid and sesquiterpenoid content and the density of glandular trichomes on the leaves, with the correlation coefficients being 0.88, 0.86 and 0.90, respectively. In contrast, there was no significant correlation between the volatile terpenoid content and the density of T-shaped trichomes on the leaves. In flowerheads, a significant correlation was identified between the emission rate of terpenoids and the number of glandular trichomes on the disc florets, with a correlation coefficient of 0.95. Interestingly, the correlation between the density of glandular trichomes and concentrations of terpenoids was insignificant. In summary, the relationship between trichomes and terpenoid chemistry in Chrysanthemum is clearly established. Such knowledge may be helpful for breeding aromatic Chrysanthemum cultivars by modulating the trichome trait.

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Therapeutic and Biomedical Potentialities of Terpenoids – A Review

Cited by 37 publications

References 63 publications

Romanian Viscum album L.—Untargeted Low-Molecular Metabolomic Approach to Engineered Viscum–AuNPs Carrier Assembly

Romanian Viscum album L.—Untargeted Low-Molecular Metabolomic Approach to Engineered Viscum–AuNPs Carrier Assembly

Reduction of Hepatic Steatosis, Oxidative Stress, Inflammation, Ballooning and Insulin Resistance After Therapy with Safranal in NAFLD Animal Model: A New Approach

Exploring the Relationship between Trichome and Terpene Chemistry in Chrysanthemum

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