Therapeutic and Preventive Effects of Piperine and its Combination with Curcumin as a Bioenhancer Against Aluminum-Induced Damage in the Astrocyte Cells

Erfen, Şebnem; Akbay, Esin

doi:10.1007/s12640-022-00600-9

Cited by 5 publications

(3 citation statements)

References 50 publications

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“…In turn, Bishnoi et al, on a haloperidolassociated neurotoxicity model, showed that simultaneous administration of curcumin and piperine leads to increased levels of neurotransmitters, reduced oxidative stress, and decreased production of inflammatory response mediators [40]. In turn, Erfen et al reported improved cell survival and a decrease in apoptosis and in the number of cytokines IL-6 and TGF-β in aluminum-treated astrocyte cells, which the authors attributed, among other things, to piperine increasing the effectiveness of curcumin [41]. Abdul Manap et al showed a synergistic effect of curcumin and piperine in an Alzheimer's disease model, where a combination of these plant-origin active substances strengthened the inhibitory effect on AchE and led to an increase in cell viability due to protection from B-amyloid-induced neurotoxicity [42].…”

Section: Resultsmentioning

confidence: 99%

Hot-Melt Extrusion as an Effective Technique for Obtaining an Amorphous System of Curcumin and Piperine with Improved Properties Essential for Their Better Biological Activities

et al. 2023

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Poor bioavailability hampers the use of curcumin and piperine as biologically active agents. It can be improved by enhancing the solubility as well as by using bioenhancers to inhibit metabolic transformation processes. Obtaining an amorphous system of curcumin and piperine can lead to the overcoming of these limitations. Hot-melt extrusion successfully produced their amorphous systems, as shown by XRPD and DSC analyses. Additionally, the presence of intermolecular interactions between the components of the systems was investigated using the FT-IR/ATR technique. The systems were able to produce a supersaturation state as well as improve the apparent solubilities of curcumin and piperine by 9496- and 161-fold, respectively. The permeabilities of curcumin in the GIT and BBB PAMPA models increased by 12578- and 3069-fold, respectively, whereas piperine’s were raised by 343- and 164-fold, respectively. Improved solubility had a positive effect on both antioxidant and anti-butyrylcholinesterase activities. The best system suppressed 96.97 ± 1.32% of DPPH radicals, and butyrylcholinesterase activity was inhibited by 98.52 ± 0.87%. In conclusion, amorphization remarkably increased the dissolution rate, apparent solubility, permeability, and biological activities of curcumin and piperine.

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Section: Resultsmentioning

confidence: 99%

Hot-Melt Extrusion as an Effective Technique for Obtaining an Amorphous System of Curcumin and Piperine with Improved Properties Essential for Their Better Biological Activities

et al. 2023

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“…Synergistic therapy experiments using H-CeO 2 @PDA, H-CeO 2 @Ce6@PDA, and H-CeO 2 @Ce6@PDA@GOx NPs were performed based on the protocol given in Section 8 of the Supporting Information . The combinatorial PDT/PTT/CDT/ST-induced cell death was investigated with dual cell staining using the acridine orange/propidium iodide (AO/PI) system. , In vitro cytotoxicity of H-CeO 2 and H-CeO 2 @Ce6@PDA@GOx NPs was also investigated using the L929 subcutaneous connective tissue cell line. The detailed protocols are given in Section 8 of the Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

“… 62 The combinatorial PDT/PTT/CDT/ST-induced cell death was investigated with dual cell staining using the acridine orange/propidium iodide (AO/PI) system. 63 , 64 In vitro cytotoxicity of H-CeO 2 and H-CeO 2 @Ce6@PDA@GOx NPs was also investigated using the L929 subcutaneous connective tissue cell line. The detailed protocols are given in Section 8 of the Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

In Vitro Synergistic Photodynamic, Photothermal, Chemodynamic, and Starvation Therapy Performance of Chlorin e6 Immobilized, Polydopamine-Coated Hollow, Porous Ceria-Based, Hypoxia-Tolerant Nanozymes Carrying a Cascade System

Süngü Akdogan,

Akbay Çetin,

Onur

et al. 2024

ACS Appl. Bio Mater.

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A synergistic therapy agent (STA) with photothermal, photodynamic, chemodynamic, and starvation therapy (PTT, PDT, CDT, and ST) functions was developed. Hollow, mesoporous, and nearly uniform CeO 2 nanoparticles (H-CeO 2 NPs) were synthesized using a staged shape templating sol−gel protocol. Chlorin e6 (Ce6) was adsorbed onto H-CeO 2 NPs, and a thin polydopamine (PDA) layer was formed on Ce6-adsorbed H-CeO 2 NPs. Glucose oxidase (GOx) was bound onto PDA-coated Ce6-adsorbed H-CeO 2 NPs to obtain the targeted STA (H-CeO 2 @Ce6@PDA@GOx NPs). A reversible photothermal conversion behavior with the temperature elevations up to 34 °C was observed by NIR laser irradiation at 808 nm. A cascade enzyme system based on immobilized GOx and intrinsic catalase-like activity of H-CeO 2 NPs was rendered on STA for enhancing the effectiveness of PDT by elevation of ROS generation and alleviation of hypoxia in a tumor microenvironment. Glucose-mediated generation of highly toxic hydroxyl radicals ( • OH) was evaluated for CDT. The effectiveness of PDT on glioblastoma T98G cells was markedly enhanced by O 2 generation started by the decomposition of glucose. A similar increase in cell death was also observed when ST and CDT functions were enhanced by photothermal action. The viability of T98G cells decreased to 10.6% by in vitro synergistic action including ST, CDT, PDT, and PTT without using any antitumor agent.

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Investigation of UV-treated mesenchymal stem cells in an in vitro wound model

Çetin,

Babayiğit,

Özdemir

et al. 2023

In Vitro Cell.Dev.Biol.-Animal

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Therapeutic and Preventive Effects of Piperine and its Combination with Curcumin as a Bioenhancer Against Aluminum-Induced Damage in the Astrocyte Cells

Cited by 5 publications

References 50 publications

Hot-Melt Extrusion as an Effective Technique for Obtaining an Amorphous System of Curcumin and Piperine with Improved Properties Essential for Their Better Biological Activities

Hot-Melt Extrusion as an Effective Technique for Obtaining an Amorphous System of Curcumin and Piperine with Improved Properties Essential for Their Better Biological Activities

In Vitro Synergistic Photodynamic, Photothermal, Chemodynamic, and Starvation Therapy Performance of Chlorin e6 Immobilized, Polydopamine-Coated Hollow, Porous Ceria-Based, Hypoxia-Tolerant Nanozymes Carrying a Cascade System

Investigation of UV-treated mesenchymal stem cells in an in vitro wound model

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