Therapeutic and Vaccine Options for COVID-19: Status after Six Months of the Disease Outbreak

Maciorowski, Dawid; Ogaugwu, Christian; Durvasula, Subba Rao; Durvasula, Ravi; Kunamneni, Adinarayana

doi:10.1177/2472555220979579

Cited by 5 publications

(4 citation statements)

References 122 publications

(109 reference statements)

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“…Vaccines prevent the spread of viral infection and reduce its mortality (4). In December 2020, the US Food and Drug Administration (FDA) introduced two mRNA vaccines produced by Pfizer and Moderna as the first COVID-19 vaccines, followed by Johnson & Johnson's adenovirus vaccine.…”

Section: Introductionmentioning

confidence: 99%

Bell's Palsy and COVID-19 Vaccination: A Systematic Review

Shahsavarinia

Mahmoodpoor

Sadeghi-Ghyassi

et al. 2022

Med. J. Islam. Republ. Iran

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Section: Introductionmentioning

confidence: 99%

Bell's Palsy and COVID-19 Vaccination: A Systematic Review

Shahsavarinia

Mahmoodpoor

Sadeghi-Ghyassi

et al. 2022

Med. J. Islam. Republ. Iran

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“…Especially during the COVID-19 pandemic like today [9]. Therefore, Scientists are racing against time to provide vaccinations proven to be effective [10].…”

Section: Introductionmentioning

confidence: 99%

Public perception on COVID-19 vaccination intention

Zaid

Pratondo

2021

IJPHS

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To resolve the health crisis caused by coronavirus disease (COVID-19), the Indonesian government is trying to implement a mandatory vaccination policy for all Indonesians. It was just that the success of this policy is largely determined by acceptance preceded by the public intention to be vaccinated, in which public perception plays a major role in determining intention. This research, therefore, aimed to evaluate and examine the role of perceived risk, benefit, and susceptibility on the COVID-19 vaccination intention. By using a cross-sectional approach, this quantitative study involved 98 participating respondents who were determined by the purposive sampling method. The results of this study finally found and proven that perceived risk (coefficient β=0.290 and T-value 2.456 with p-value=0.011), perceived benefits (β= 0.394 and T-value 3.873 with p-value=0.000), and perceived susceptibility (β=0.233 and T-value 3,230 with p-value=0.001) had a positive and significant effect on the COVID-19 vaccination intention.

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“…In our cohort, while differences were observed in the administration of hydroxychloroquine or corticosteroids among those with baseline high or low NT-proBNP values, subsequent studies have revealed that the use of hydroxychloroquine in the acute phase does not reduce mortality [ 33 – 34 ], nor do corticosteroids benefit non-severe patients [ 33 , 35 ]. As a result, their widespread use is no longer recommended.…”

Section: Discussionmentioning

confidence: 84%

“…High hs-cTnT levels in the acute phase of COVID-19 have been associated with worse long-term prognosis [ 14 , 33 ] but there is limited data on the potential association between NT-proBNP levels in the acute phase and long-term prognosis. Our findings indicate that high NT-proBNP levels may be able to identify patients with a high risk of complications both during and after hospitalization for COVID-19 infection.…”

Section: Discussionmentioning

confidence: 99%

Baseline NT-proBNP levels as a predictor of short-and long-term prognosis in COVID-19 patients: a prospective observational study

Mojón-Álvarez,

Giralt,

Carreras-Mora

et al. 2024

BMC Infect Dis

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Background Up to 20% of COVID-19 patients can suffer COVID-19-related myocardial injury. Elevated cardiac biomarkers, such as hs-cTnT and NT-proBNP, have been related to worse short-term prognosis. However, data on NT-proBNP and long-term prognosis are scarce. We have evaluated the potential association of baseline age-adjusted NT-proBNP levels and outcomes at one-year follow-up in COVID-19 patients. Methods This was a single-center prospective study of 499 COVID-19 patients in whom NT-proBNP was assessed at hospital admission. NT-proBNP levels were age-adjusted and patients were classified as high or low NT-proBNP. Clinical and demographic characteristics, comorbidities, laboratory results, and in-hospital complications and mortality were compared between the two groups. Survivors of the acute phase of COVID-19 were followed up for one year from admission to detect readmissions and mortality. Results The 68 patients with high NT-proBNP levels at hospital admission were older, with more cardiovascular risk factors, cardiovascular disease, comorbidities, myocardial injury, and higher levels of inflammatory markers than patients with low NT-proBNP levels. They also had more in-hospital complications and a higher acute-phase mortality rate (60.3% vs. 10.2%, p < 0.001). High NT-proBNP levels were an independent marker of death during hospitalization (HR 1.95; CI 1.07–3.52). At one-year follow-up, high NT-proBNP levels were independently associated with mortality (HR 2.69; CI 1.47–4.89). Among survivors of the acute phase of COVID-19, there were no differences in hospital readmissions between those with high vs. low NT-proBNP levels, but survivors with high baseline NT-proBNP levels showed a higher 1-year mortality rate (7.4% vs. 1.3%, p = 0.018). Conclusions High age-adjusted NT-proBNP levels at the time of hospital admission for COVID-19 are associated with poor short and long-term prognosis. High NT-proBNP seems also to be related to worse prognosis in survivors of the acute phase of COVID-19. A closer follow-up on these patients may be crucial.

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Therapeutic and Vaccine Options for COVID-19: Status after Six Months of the Disease Outbreak

Cited by 5 publications

References 122 publications

Bell's Palsy and COVID-19 Vaccination: A Systematic Review

Bell's Palsy and COVID-19 Vaccination: A Systematic Review

Public perception on COVID-19 vaccination intention

Baseline NT-proBNP levels as a predictor of short-and long-term prognosis in COVID-19 patients: a prospective observational study

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