Therapeutic Application of Berberine: a Consolidated Review

Mana, Techi; Devi, Oinam Bidyalaxmi; Singh, Yengkhom Disco

doi:10.1007/s40495-023-00330-2

Cited by 5 publications

(5 citation statements)

References 107 publications

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“…29 Rhizoma coptidis, the source of berberine (BBR), is a bioactive component known for its impact on glucose metabolism, lipid profiles, and congestive heart failure. 30 Additionally, BBR protects against damage caused by oxidative stress, 31 such as the oxidative stress seen in the early stages of DR development, when reactive oxygen species levels are elevated. 32 In addition, BBR reduces oxidative stress caused by fatty acids and glutamate, and protects cells from apoptosis caused by oxidative damage.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Bioactive Compound-Derived Nanoparticle Against Diabetic Retinopathy Through the Modulation of the NF-κB Signaling Pathway

Li,

Lv,

Xiao

et al. 2024

ACS Omega

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Diabetic retinopathy is a prevalent and severe microvascular complication of diabetes, often causing visual impairment and blindness in adults. This condition significantly impacts the quality of life for many diabetes patients worldwide. Berberine (BBR), a bioactive compound known for its effects on blood glucose levels, has shown promise in managing diabetic complications. However, the exact mechanism of how BBR influences the development of diabetic retinopathy remains unclear. In this study, we focused on synthesizing a formulation derived from BBR and assessing its protective effects against diabetic retinopathy. The formulation was created using a green synthesis method and thoroughly characterized. In vitro studies demonstrated the antioxidant activity of the formulation against 2,2-diphenyl-1-picryl-hydrazyl-hydrate. We also examined the NF-κB signaling pathway at a molecular level using real-time polymerase chain reaction. To mimic diabetic retinopathy in a controlled setting, a diabetic rat model was established through streptozotocin injection. The rats were divided into normal, diabetic, and treatment groups. The treatment group received the formulated treatment via intragastric administration for several weeks, while the other groups received normal saline. Evaluation of histopathological characteristics and microstructural changes in the retina using hematoxylin and eosin staining revealed that the bioactive compound-derived nanoparticle exhibited favorable biological, chemical, and physical properties. Treatment with the formulation effectively reduced oxidative stress induced by diabetes and inhibited the NF-κB signaling pathway in the diabetic rat model. Under high glucose conditions, oxidative stress was heightened, leading to mitochondria-dependent cell apoptosis in Muller cells via the activation of the NF-κB signaling pathway. The bioactive compound-derived formulation counteracted these effects by decreasing IκB phosphorylation, preventing NF-κB nuclear translocation, and deactivating the NF-κB signaling pathway. Furthermore, treatment with the bioactive compound-derived formulation mitigated retinal micro-and ultrastructural changes associated with diabetic retinopathy. These results indicate that the formulation protects against diabetic retinopathy by suppressing oxidative stress, reducing cell apoptosis, and deactivating the NF-κB signaling pathway. This suggests that the bioactive compoundderived formulation could be a promising therapeutic option for diabetic retinopathy.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of Bioactive Compound-Derived Nanoparticle Against Diabetic Retinopathy Through the Modulation of the NF-κB Signaling Pathway

Li,

Lv,

Xiao

et al. 2024

ACS Omega

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“…The World Health Organization also supports conventional plant-based treatments due to their accessibility, safety for long-term uses, and relatively low production costs. This shift toward natural remedies occurred mainly because some synthetic pharmaceutical drugs may have harmful side effects when used for the long-term treatment of chronic diseases [1]. Therefore, based on traditional medical systems (Ayurvedic and Chinese), phytotherapy in chronic disorders is currently used as an alternative treatment worldwide.…”

Section: Introductionmentioning

confidence: 99%

“…Berberine, the specific isoquinoline alkaloid mainly extracted from common barberry root and stem barks, is formulated for oral administration alone or in various combinations. The administration of berberine-based phytotherapeutics could have a beneficial impact on lipid and carbohydrate metabolism, particularly on glucose homeostasis, being helpful in weight loss, diabetes mellitus [4] and endocrine disorders, liver diseases [5], cardiovascular diseases, atherosclerosis, neurodegenerative diseases, rheumatic diseases, and infectious diseases [1]. Several studies reported berberine-induced toxicity in humans and mice [1].…”

Section: Introductionmentioning

confidence: 99%

“…The administration of berberine-based phytotherapeutics could have a beneficial impact on lipid and carbohydrate metabolism, particularly on glucose homeostasis, being helpful in weight loss, diabetes mellitus [4] and endocrine disorders, liver diseases [5], cardiovascular diseases, atherosclerosis, neurodegenerative diseases, rheumatic diseases, and infectious diseases [1]. Several studies reported berberine-induced toxicity in humans and mice [1]. However, toxic phenomena could be diminished through berberine combination with other phytochemicals or plant extracts.…”

Section: Introductionmentioning

confidence: 99%

“…However, toxic phenomena could be diminished through berberine combination with other phytochemicals or plant extracts. Synergistic effects would also be expected in adequate combinations [1]. Moreover, B. vulgaris and berberine display anticancer effects through various cell signaling pathways' modulation [6], diminishing tumor cell viability and reducing their multiplication in various neoplasia (lung, breast, ovary, gastric cancer) [1].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and Cytotoxic Properties of Berberis vulgaris (L.) Stem Bark Dry Extract

Ivan,

Olaru,

Popovici

et al. 2024

Molecules

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Berberis vulgaris (L.) has remarkable ethnopharmacological properties and is widely used in traditional medicine. The present study investigated B. vulgaris stem bark (Berberidis cortex) by extraction with 50% ethanol. The main secondary metabolites were quantified, resulting in a polyphenols content of 17.6780 ± 3.9320 mg Eq tannic acid/100 g extract, phenolic acids amount of 3.3886 ± 0.3481 mg Eq chlorogenic acid/100 g extract and 78.95 µg/g berberine. The dried hydro-ethanolic extract (BVE) was thoroughly analyzed using Ultra-High-Performance Liquid Chromatography coupled with High-Resolution Mass Spectrometry (UHPLC–HRMS/MS) and HPLC, and 40 bioactive phenolic constituents were identified. Then, the antioxidant potential of BVE was evaluated using three methods. Our results could explain the protective effects of Berberidis cortex EC50FRAP = 0.1398 mg/mL, IC50ABTS = 0.0442 mg/mL, IC50DPPH = 0.2610 mg/mL compared to ascorbic acid (IC50 = 0.0165 mg/mL). Next, the acute toxicity and teratogenicity of BVE and berberine—berberine sulfate hydrate (BS)—investigated on Daphnia sp. revealed significant BS toxicity after 24 h, while BVE revealed considerable toxicity after 48 h and induced embryonic developmental delays. Finally, the anticancer effects of BVE and BS were evaluated in different tumor cell lines after 24 and 48 h of treatments. The MTS assay evidenced dose- and time-dependent antiproliferative activity, which was higher for BS than BVE. The strongest diminution of tumor cell viability was recorded in the breast (MDA-MB-231), colon (LoVo) cancer, and OSCC (PE/CA-PJ49) cell lines after 48 h of exposure (IC50 < 100 µg/mL). However, no cytotoxicity was reported in the normal epithelial cells (HUVEC) and hepatocellular carcinoma (HT-29) cell lines. Extensive data analysis supports our results, showing a significant correlation between the BVE concentration, phenolic compounds content, antioxidant activity, exposure time, and the viability rate of various normal cells and cancer cell lines.

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Ferroptosis: Latest evidence and perspectives on plant‐derived natural active compounds mitigating doxorubicin‐induced cardiotoxicity

Wang,

Liu

et al. 2024

J of Applied Toxicology

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Doxorubicin (DOX) is a chemotherapy drug widely used in clinical settings, acting as a first‐line treatment for various malignant tumors. However, its use is greatly limited by the cardiotoxicity it induces, including doxorubicin‐induced cardiomyopathy (DIC). The mechanisms behind DIC are not fully understood, but its potential biological mechanisms are thought to include oxidative stress, inflammation, energy metabolism disorders, mitochondrial damage, autophagy, apoptosis, and ferroptosis. Recent studies have shown that cardiac injury induced by DOX is closely related to ferroptosis. Due to their high efficacy, availability, and low side effects, natural medicine treatments hold strong clinical potential. Currently, natural medicines have been shown to mitigate DOX‐induced ferroptosis and ease DIC through various functions such as antioxidation, iron ion homeostasis correction, lipid metabolism regulation, and mitochondrial function improvement. Therefore, this review summarizes the mechanisms of ferroptosis in DIC and the regulation by natural plant products, with the expectation of providing a reference for future research and development of inhibitors targeting ferroptosis in DIC.This review explores the mechanisms of ferroptosis in doxorubicin‐induced cardiomyopathy (DIC) and summarizes how natural plant products can alleviate DIC by inhibiting ferroptosis through reducing oxidative stress, correcting iron ion homeostasis, regulating lipid metabolism, and improving mitochondrial function.

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Therapeutic Application of Berberine: a Consolidated Review

Cited by 5 publications

References 107 publications

Protective Effects of Bioactive Compound-Derived Nanoparticle Against Diabetic Retinopathy Through the Modulation of the NF-κB Signaling Pathway

Protective Effects of Bioactive Compound-Derived Nanoparticle Against Diabetic Retinopathy Through the Modulation of the NF-κB Signaling Pathway

Antioxidant and Cytotoxic Properties of Berberis vulgaris (L.) Stem Bark Dry Extract

Ferroptosis: Latest evidence and perspectives on plant‐derived natural active compounds mitigating doxorubicin‐induced cardiotoxicity

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