Therapeutic Application of Glutinous Rice Ferment Extract for Atopic Eczema

Abstract

Atopic eczema is a relapsing inflammatory skin condition which is characterized by severe itching, polymorphic skin lesions, repeated attacks and so on. Current research believes that there are two major links in the occurrence of eczema, including immune abnormalities of allergic inflammation and damage to the skin barrier. In this paper, the anti-eczema and antipruritic effects of glutinous rice ferment extract were explored through in vitro and animal experimental models. We found that glutinous rice ferment extract could not only reduce TSLP and reduce inflammation, but also repair damaged skin barrier by upregulating the expression of filaggrin. On animal models, the basic formula containing glutinous rice ferment extract could significantly increase the itching threshold and relieve itching. In summary, glutinous rice ferment extract has been shown to have a good anti-eczema effect, which provides a model for the treatment of eczema.