Therapeutic applications of compounds in the Magnolia family

Lee, Young-Jung; Lee, Yoot Mo; Lee, Chong-Kil; Jung, Jae Kyung; Han, Sang Bae; Hong, Jin Tae

doi:10.1016/j.pharmthera.2011.01.010

Cited by 390 publications

(337 citation statements)

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“…Magnolia trees are mainly distributed in East and Southeast Asia (Cui et al, 2013) and are generally very attractive thanks to their fragrant and dazzling flowers (Lee et al, 2011). The root and branch bark are collected from April to June and dried in the shade; the stem bark is slightly decocted in boiling water and piled up in a wet place until its inner surface becomes purplish-brown or dark brown, softened by steaming, and rolled and dried (CPC, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…In China, a number of prescriptions containing Houpo are still in use in modern clinical practice (Yu et al, 2012). In Japan, two prescriptions containing Magnolia bark, HangeKoboku-To (Japanese name for Banxia Houpo Tang) (Iwasaki et al, 2000) and Saiboku-To (Table 1), are also still in use in modern clinical practice (Li N. et al, 2007;Lee et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Poivre

Duez

2017

J. Zhejiang Univ. Sci. B

112

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Traditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark of Magnolia officinalis Rehder & E. Wilson, known under the pinyin name "Houpo", has been traditionally used in Chinese and Japanese medicines for the treatment of anxiety, asthma, depression, gastrointestinal disorders, headache, and more. Moreover, Magnolia bark extract is a major constituent of currently marketed dietary supplements and cosmetic products. Much pharmacological activity has been reported for this herb and its major compounds, notably antioxidant, anti-inflammatory, antibiotic and antispasmodic effects. However, the mechanisms underlying this have not been elucidated and only a very few clinical trials have been published. In vitro and in vivo toxicity studies have also been published and indicate some intriguing features. The present review aims to summarize the literature on M. officinalis bark composition, utilisation, pharmacology, and safety.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Poivre

Duez

2017

J. Zhejiang Univ. Sci. B

112

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“…Although the first characterisation of honokiol from Magnolia obovata was reported in 1972 (Maruyama and Kuribara 2006), this natural product actually has been widely used in traditional medicine in China, Japan and Korea for a long time (Maruyama and Kuribara 2006; Lee et al 2011). Honokiol started to capture attention in recent 20 years mainly because of the finding of its promising therapeutic potential to treat multiple human diseases (especially for tumour and thrombus) (Fukuyama et al 2002; Hu et al 2005; Arora et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Antifungal compound honokiol triggers oxidative stress responsive signalling pathway and modulates central carbon metabolism

Wang

Yan

2016

Mycology

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The fast growing evidences have shown that the plant-derived compound honokiol is a promising candidate for treating multiple human diseases, such as inflammation and cancer. However, the mode-of-action (MoA) of honokiol remains largely unclear. Here, we studied the antifungal activity of honokiol in fission yeast model, with the goal of understanding the honokiol’s mechanism of action from the molecular level. We found that honokiol can inhibit the yeast growth at a dose-dependent way. Microarray analysis showed that honokiol has wide impacts on the fission yeast transcription levels (in total, 512 genes are up-regulated, and 42 genes are down-regulated). Gene set enrichment analysis indicated that over 45% up-regulated genes belong to the core environmental stress responses category. Moreover, network analysis suggested that there are extensive gene–gene interactions amongst the co-expression gene lists, which can assemble several biofunctionally important modules. It is noteworthy that several key components of central carbon metabolism, such as glucose transporters and metabolic enzymes of glycolysis, are involved in honokiol’s MoA. The complexity of the honokiol’s MoA displayed in previous studies and this work demonstrates that multiple omics approaches and bioinformatics tools should be applied together to achieve the complete scenario of honokiol’s antifungal function.

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“…1,2 The pharmacological effects were proposed to be mainly mediated by the neolignans honokiol (1), 4-methoxyhonokiol (2), magnolol (3), and (R)-8,9-dihydroxydihydromagnolol (4). 2−4 An intensive search for their molecular targets revealed an interaction of honokiol and magnolol with a variety of enzymes and receptors at micromolar concentrations.…”

mentioning

confidence: 99%

“…9 Furthermore, the neolignans share structural similarity with some highly potent synthetic CB receptor ligands, such as CP55,940 (5), but also plant-derived biaryl CBs. 8,10,11 CB receptors belong to the G protein-coupled receptor (GPCR) superfamily and are divided into two distinct subtypes designated CB 1 and CB 2 , both of which are linked to an inhibition of adenylate cyclase. 12 CB 1 activation mediates analgesia, stimulation of appetite, and euphoria, among other effects.…”

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confidence: 99%

Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB₂ Receptors and Blockade of the Related GPR55

Rempel

Fuchs

Hinz

et al. 2012

ACS Med. Chem. Lett.

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ABSTRACT:The bark of Magnolia of ficinalis is used in Asian traditional medicine for the treatment of anxiety, sleeping disorders, and allergic diseases. We found that the extract and its main bioactive constituents, magnolol and honokiol, can activate cannabinoid (CB) receptors. In cAMP accumulation studies, magnolol behaved as a partial agonist (EC 50 = 3.28 μM) with selectivity for the CB 2 subtype, while honokiol was less potent showing full agonistic activity at CB 1 and antagonistic properties at CB 2 . We subsequently synthesized the major metabolites of magnolol and found that tetrahydromagnolol (7) was 19-fold more potent than magnolol (EC 50 CB 2 = 0.170 μM) exhibiting high selectivity versus CB 1 . Additionally, 7 behaved as an antagonist at GPR55, a CB-related orphan receptor (K B = 13.3 μM, β-arrestin translocation assay). Magnolol and its metabolites may contribute to the biological activities of Magnolia extract via the observed mechanisms of action. Furthermore, the biphenylic compound magnolol provides a simple novel lead structure for the development of agonists for CB receptors and antagonists for the related GPR55.

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Therapeutic applications of compounds in the Magnolia family

Cited by 390 publications

References 245 publications

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Antifungal compound honokiol triggers oxidative stress responsive signalling pathway and modulates central carbon metabolism

Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB₂ Receptors and Blockade of the Related GPR55

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Therapeutic applications of compounds in the Magnolia family

Cited by 390 publications

References 245 publications

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Antifungal compound honokiol triggers oxidative stress responsive signalling pathway and modulates central carbon metabolism

Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55

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Product

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Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB₂ Receptors and Blockade of the Related GPR55