Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective

Abstract

Diabetes is a metabolic disease with multifactorial causes which requires lifelong drug therapy as well as lifestyle changes. There is now growing scientific evidence to support the effectiveness of the use of herbal supplements in the prevention and control of diabetes. Curcumin is one of the most studied bioactive components of traditional medicine, but its physicochemical characteristics are represented by low solubility, poor absorption, and low efficacy. Nanotechnology-based pharmaceutical formulations can help overcome the problems of reduced bioavailability of curcumin and increase its antidiabetic effects. The objectives of this review were to review the effects of nanocurcumin on DM and to search for databases such as PubMed/MEDLINE and ScienceDirect. The results showed that the antidiabetic activity of nanocurcumin is due to complex pharmacological mechanisms by reducing the characteristic hyperglycemia of DM. In light of these results, nanocurcumin may be considered as potential agent in the pharmacotherapeutic management of patients with diabetes.

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

“…The therapeutic advantage of these natural products is their minimal toxicity and reduced side effects [ 92 , 128 , 129 ]. But natural bioactive compounds can interact with many proteins, which is why it is very important to elucidate the mechanisms of action of natural products, especially those that are used in our diet [ 130 ].…”

Pharmacological effects and therapeutic potential of natural compounds in neuropsychiatric disorders: An update

“…Curcumin in Curcuma longa was found for its neuroprotective activities and cellular signalling role in regulating oxidative stress ( Salehi et al, 2020 ). Moreover, curcumin could reduce inflammatory factors in diseases and exhibit antioxidant radical scavenging activities ( Salehi et al, 2019a ; Quispe et al, 2022 ). As a potential treatment for autism, Ginkgo Biloba extract was used accompanied by risperidone.…”

Therapeutic applications of curcumin nanomedicine formulations in cystic fibrosis

“…While it might have reached China before 700 BCE, East Africa before 800 BCE, West Africa before 1200 BCE, and Jamaica in the eighteenth century (Prasad et al 2014). In traditional medicine, turmeric is used for the treatment of rheumatoid arthritis, chronic anterior uveitis, conjunctivitis, skin cancer, smallpox, chickenpox, wound healing, urinary tract infections, liver ailments, strengthening the overall energy of the body, dispelling worms, regulating menstruation, dissolving gall stones, and for several digestive disorders, amongst other conditions (Quispe et al 2022;Akaberi et al 2021).…”