Therapeutic applications of dental pulp stem cells in regenerating dental, periodontal and oral-related structures

Grawish, Mohammed E.; Saeed, Mahmoud A.; Sultan, Nessma; Scheven, Ben A.

doi:10.13105/wjma.v9.i2.176

Cited by 7 publications

(18 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the evidence proving that—in contrast to the other dental tissues—the dental pulp is significantly richer with stem cells, hDPSCs and SHED became “a promised land” for future preclinical and clinical study [ 9 , 12 , 13 , 26 , 27 , 35 ]. Nevertheless, hDPSCs and SHEDs possess unique features different from BMMSCs [ 38 ].…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

“…BMMSCs were successfully used in the regeneration of damaged cartilage tissue [ 54 , 55 ], bone ligaments [ 56 ], and discs between the bones of the spine [ 57 , 58 ]. Only a few reports described clinical trials that used hDPSCs or SHEDs as a tool in regenerative medicine [ 9 , 42 , 59 , 60 ]. Autologous hDPSCs were successfully used in patients post-third molar extraction [ 59 ], with periodontal and bone defects [ 9 , 60 ], and in pulp regeneration [ 42 ].…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

“…A majority of clinical trials have been performed using MSCs aspirated from bone marrow [ 8 ]. It is worth underlining that MSCs isolated from human dental pulp tissue have also been used in clinical trials as a tool in regenerative medicine [ 9 ]. Clinical data continue to show successful applications of MSCs, and the completed trials have been listed at (accessed on 1 November 2021), the database of The National Institutes of Health [ 8 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Most clinical trials use a similar procedure to prepare MSCs for therapy. Depending on the source, stem cells are aspirated from bone marrow or isolated from adipose or pulp tissue and cultured using an optimal medium inducing MSC proliferation [ 8 , 9 ]. Manufacturing should take place in a closed and aseptic environment.…”

Section: Introductionmentioning

confidence: 99%

“…In the US, GMP human MSC production is regulated by FDA CFR Title 21, part 1271, subpart D, sections 145e320, focusing on current good tissue practice requirements, which provide exemptions, maintenance of quality procedure, process control, and validation [ 16 ]. All current clinical trials have recognized the importance of developing standardized protocols that comply with international regulations to ensure the effectiveness and safety of the treatment [ 8 , 9 ]. In light of these stipulations, potential novel therapies have emerged in regenerative medicine and tissue engineering [ 4 , 8 , 14 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential

Bär

Lis-Nawara

Grelewski

2021

IJMS

View full text Add to dashboard Cite

The therapeutic potential of the dental pulp stem (DSC) cell-derived secretome, consisting of various biomolecules, is undergoing intense research. Despite promising in vitro and in vivo studies, most DSC secretome-based therapies have not been implemented in human medicine because the paracrine effect of the bioactive factors secreted by human dental pulp stem cells (hDPSCs) and human exfoliated deciduous teeth (SHEDs) is not completely understood. In this review, we outline the current data on the hDPSC- and SHED-derived secretome as a potential candidate in the regeneration of bone, cartilage, and nerve tissue. Published reports demonstrate that the dental MSC-derived secretome/conditional medium may be effective in treating neurodegenerative diseases, neural injuries, cartilage defects, and repairing bone by regulating neuroprotective, anti-inflammatory, antiapoptotic, and angiogenic processes through secretome paracrine mechanisms. Dental MSC-secretomes, similarly to the bone marrow MSC-secretome activate molecular and cellular mechanisms, which determine the effectiveness of cell-free therapy. Many reports emphasize that dental MSC-derived secretomes have potential application in tissue-regenerating therapy due to their multidirectional paracrine effect observed in the therapy of many different injured tissues.

show abstract

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential

Bär

Lis-Nawara

Grelewski

2021

IJMS

View full text Add to dashboard Cite

show abstract

Stem cells in regenerative dentistry: Current understanding and future directions

Shah,

Aghazadeh,

Rajasingh

et al. 2024

Journal of Oral Biosciences

View full text Add to dashboard Cite

Preventive Functions of Hemp-Derived Biomaterials Against Periodontal Deterioration Caused by Fine Dust

Kim,

Park,

Yun

et al. 2024

Preprint

View full text Add to dashboard Cite

Although fine dust can cause various disorders, including cardiovascular, neurological, renal, reproductive, motor, systemic, respiratory, and cancerous diseases, there are not enough research for an oral disease. In this study we used various methods, including quantitative PCR, flow cytometry, immunocytochemistry, ELISA, and Alizarin O staining, to reveal the preventive effects of hemp-derived biomaterials in periodontal cells against fine dust. In this study, the two biomaterials (MSE; mature hemp stem extract and IE; induced exosomes derived from gingival cells exposed to MSE) revealed three main biological functions against fine dust. First, two materials suppressed the levels of inflammatory genes and activated anti-inflammatory genes in gingival cells. Second, these materials activated differentiation to osteoblast, periodontal ligament cells (PDLCs) and pulp progenitor cells (PPCs) from periodontal ligament stem cells (PDLSCs). Third, IE and MSE activated upregulation of LL-37 and down-regulation of MCP-1 in gingival cells and PDLSCs, respectively. Consequently, MSE and IE showed potential as a functional biomaterial in various fields, including pharmaceuticals, cosmetics, and foods.

show abstract

Therapeutic applications of dental pulp stem cells in regenerating dental, periodontal and oral-related structures

Cited by 7 publications

References 53 publications

Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential

Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential

Stem cells in regenerative dentistry: Current understanding and future directions

Preventive Functions of Hemp-Derived Biomaterials Against Periodontal Deterioration Caused by Fine Dust

Contact Info

Product

Resources

About