Therapeutic applications of mesenchymal stromal cells

Brooke, Gary; Cook, Matthew; Blair, Chris; Han, Rachel; Heazlewood, Celena; Jones, Ben; Kambouris, Melinda E.; Kollar, Kate; McTaggart, Steven; Pelekanos, Rebecca A.; Rice, Alison; Rossetti, Tony; Atkinson, Kerry

doi:10.1016/j.semcdb.2007.09.012

Cited by 228 publications

(185 citation statements)

References 138 publications

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“…aMSCs showed enhanced anti-inflammatory IL-10 secretion [73] together with decreased pro-inflammatory TNF-α, INF-γ, IL-1β and their downstream effects on various elements of the immune system. aMSCs, whether those who home to the radiation injury site or those who remain at the primary implantation site, can produce such paracrine effects [77].…”

Section: Discussionmentioning

confidence: 94%

“…They also have the ability to home to the site of tissue injury after irradiation and inflammation [74,77,78]. aMSCs are promising for cellular therapies due to their prominent anti-inflammatory effects, enhancing IL-10 secretion, ease of isolation, high cell count after expansion, as well as their source abundance [73]. In radiation-induced normal tissue injury, aMSCs have shown significant repair of cutaneous radiation syndrome [79][80][81][82][83] and photo-aging [84], RT-induced acute salivary gland [85] and intestine injuries [70,[86][87][88], and chronic injuries induced by radiotherapy [80,89].…”

Section: Methodsmentioning

confidence: 99%

“…However, MSCs isolated from adipose tissue are characterized by their enhanced anti-inflammatory properties, production of higher levels of the anti-inflammatory cytokine Interleukin-10 (IL-10), high yield upon expansion in cultures, ease of isolation, and source abundance [73].…”

Section: Mesenchymal Stromal/stem Cells Therapymentioning

confidence: 99%

“…In addition, MSCs home to the site of tissue injury that is caused irradiation and inflammation [74,77,78]. aMSCs are promising for cellular therapies due to their prominent anti-inflammatory effects, enhancing IL-10 secretion, ease of isolation, high cell count after expansion, as well as their source abundance [73]. …”

Section: Adipose Tissue-derived Mscs (Amscs)mentioning

confidence: 99%

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Adipose mesenchymal stromal cells minimize and repair radiation-induced oral mucositis

et al. 2016

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Section: Discussionmentioning

confidence: 94%

Section: Methodsmentioning

confidence: 99%

Section: Mesenchymal Stromal/stem Cells Therapymentioning

confidence: 99%

Section: Adipose Tissue-derived Mscs (Amscs)mentioning

confidence: 99%

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Adipose mesenchymal stromal cells minimize and repair radiation-induced oral mucositis

et al. 2016

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“…MSCs are post-natal progenitor/stem cells that can differentiate into multiple mesodermal lineages including bone, cartilage, adipose tissue, and some muscle lineages [3,4]. First isolated from the adult bone marrow (BM), MSCs have now been isolated from many other adult organs [5,6]. However, the number of BMMSCs decline with increasing donor age [7] and procurement of these cells from adult organs require invasive procedures.…”

mentioning

confidence: 99%

Age-Related Decreases of Serum-Response Factor Levels in Human Mesenchymal Stem Cells Are Involved in Skeletal Muscle Differentiation and Engraftment Capacity

Ting

Yen

2014

Stem Cells and Development

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Skeletal muscle (SkM) comprise *40% of human body weight. Injury or damage to this important tissue can result in physical disability, and in severe cases is difficult for its endogenous stem cell-the satellite cellto reverse effectively. Mesenchymal stem cells (MSC) are postnatal progenitor/stem cells that possess multilineage mesodermal differentiation capacity, including toward SkM. Adult bone marrow (BM) is the beststudied source of MSCs; however, aging also decreases BMMSC numbers and can adversely affect differentiation capacity. Therefore, we asked whether human sources of developmentally early stage mesenchymal stem cells (hDE-MSCs) isolated from embryonic stem cells, fetal bone, and term placenta could be cellular sources for SkM repair. Under standard muscle-inducing conditions, hDE-MPCs differentiate toward a SkM lineage rather than cardiomyocytic or smooth muscle lineages, as evidenced by increased expression of SkM-associated markers and in vitro myotube formation. In vivo transplantation revealed that SkM-differentiated hDE-MSCs can efficiently incorporate into host SkM tissue in a mouse model of SkM injury. In contrast, adult BMMSCs do not express SkM-associated genes after in vitro SkM differentiation nor engraft in vivo. Further investigation of possible factors responsible for this difference in SkM differentiation potential revealed that, compared with adult BMMSCs, hDE-MSCs expressed higher levels of serum response factor (SRF), a transcription factor critical for SkM lineage commitment. Moreover, knockdown of SRF in hDE-MSCs resulted in decreased expression of SkM-related genes after in vitro differentiation and decreased in vivo engraftment. Our results implicate SRF as a key factor in age-related SkM differentiation capacity of MSCs, and demonstrate that hDEMSCs are possible candidates for SkM repair.

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