Therapeutic Applications of Metal and Metal-Oxide Nanoparticles: Dermato-Cosmetic Perspectives

Abstract

Invention of novel nanomaterials guaranteeing enhanced biomedical performance in diagnostics and therapeutics, is a perpetual initiative. In this regard, the upsurge and widespread usage of nanoparticles is a ubiquitous phenomenon, focusing predominantly on the application of submicroscopic (< 100 nm) particles. While this is facilitated attributing to their wide range of benefits, a major challenge is to create and maintain a balance, by alleviating the associated toxicity levels. In this minireview, we collate and discuss particularly recent advancements in therapeutic applications of metal and metal oxide nanoparticles in skin and cosmetic applications. On the one hand, we outline the dermatological intrusions, including applications in wound healing. On the other hand, we keep track of the recent trends in the development of cosmeceuticals via nanoparticle engrossments. The dermato-cosmetic applications of metal and metal oxide nanoparticles encompass diverse aspects, including targeted, controlled drug release, and conferring ultraviolet and antimicrobial protections to the skin. Additionally, we deliberate on the critical aspects in comprehending the advantage of rheological assessments, while characterizing the nanoparticulate systems. As an illustration, we single out psoriasis, to capture and comment on the nanodermatology-based curative standpoints. Finally, we lay a broad outlook and examine the imminent prospects.

Phloroglucinol-Gold and -Zinc Oxide Nanoparticles: Antibiofilm and Antivirulence Activities towards Pseudomonas aeruginosa PAO1

“…The effect of PG-AuNPs and PG-ZnONPs on the formation of biofilm, which is one of the most important phenotypic characteristics exhibited by P. aeruginosa in the course of chronic infection, was investigated [26]. Concentrations of PG-AuNPs and PG-ZnONPs were selected in the range of 32 to 512 µg/mL.…”

“…Additionally, metallic nanoparticles are described as an effective drug delivery vehicle with minimal toxicity, specific targeting, and controlled release [23,24]. The mechanism of antimicrobial activity of metal and metal oxide nanoparticles has been well understood, including the generation of cellular reactive oxygen species, cell membrane damage, cell membrane penetration, disruption of signaling pathways, inhibition of protein synthesis, and DNA damage [25,26].…”

Bacterial-mediated synthesis and characterization of copper oxide nanoparticles with antibacterial, antioxidant, and anticancer potentials

“…Nanotechnology is as an evolving interdisciplinary research field that focuses on nanoparticles (NPs) with improved size-dependent features, such as robustness of the colloidal moiety, great surface area and high bioavailability to name a few ( Pan et al, 2021 ). Conventionally, synthesis of NPs can be performed by physical, chemical and mechanical approaches, however, high cost and toxicity of these methods have shifted fabrication of NPs toward biological systems ( Chandrasekaran et al, 2020 ; Lahiri et al, 2021 ).…”

Non-ROS-Mediated Cytotoxicity of ZnO and CuO in ML-1 and CA77 Thyroid Cancer Cell Lines

“…Metals such as gold, silver, titanium, copper, zinc, and aluminum have all been used to synthesize nanomaterials, as well as their oxides, i.e., silver oxide, copper oxide, magnesium oxide, calcium oxide, and zinc oxide. These common nanomaterials exhibit magnetic, fluorescence quenching, and dielectric properties [ 1 , 2 ]. In particular, MONPs are no more than 100 nm in size and are one of the most studied nanomaterials against multidrug-resistant bacteria [ 3 , 4 ].…”