2021
DOI: 10.1016/j.biopha.2021.111377
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Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases

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Cited by 67 publications
(42 citation statements)
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“…These two cytoprotective systems are related in complex functional crosstalk, i.e., (a) some direct antioxidants are required for the catalytic functions of redox proteins and (b) several antioxidant proteins participate in the synthesis and/or homeostasis of direct antioxidants. Direct antioxidants are diverse and common in nature but, importantly and less explored, many inducers of cytoprotective proteins have been isolated from edible plants, e.g., sulforaphane from broccoli and curcumin from turmeric [108,109]; ergothioneine, polyphenols and flavonoids from a variety of edible mushrooms [110,111] and DHA (but not arachidonic acid, the most abundant n-6 LCPUFA, or eicosapentaenoic acid, EPA, the second important n-3 LCPUFA) from different sources, mainly marine fish and invertebrates [112,113].…”
Section: Dha: the Ultimate Indirect Antioxidantmentioning
confidence: 99%
“…These two cytoprotective systems are related in complex functional crosstalk, i.e., (a) some direct antioxidants are required for the catalytic functions of redox proteins and (b) several antioxidant proteins participate in the synthesis and/or homeostasis of direct antioxidants. Direct antioxidants are diverse and common in nature but, importantly and less explored, many inducers of cytoprotective proteins have been isolated from edible plants, e.g., sulforaphane from broccoli and curcumin from turmeric [108,109]; ergothioneine, polyphenols and flavonoids from a variety of edible mushrooms [110,111] and DHA (but not arachidonic acid, the most abundant n-6 LCPUFA, or eicosapentaenoic acid, EPA, the second important n-3 LCPUFA) from different sources, mainly marine fish and invertebrates [112,113].…”
Section: Dha: the Ultimate Indirect Antioxidantmentioning
confidence: 99%
“…Likewise, it is also identified by predominant neuronal loss in substantia nigra pars compacta (SNpc) and in the striatum of mid brain area ( Prakash et al, 2014 ; Moors et al, 2017 ; Yadav et al, 2017 ), Various therapeutic targets are identified for the treatment of PD. Mucuna pruriens and some edible mushrooms offer significant Anti-Parkinsonian activity by acting on these targets ( Rai et al, 2017 , 2021 ).…”
Section: Current Approaches To the Treatment Of Parkinson’s Diseasementioning
confidence: 99%
“…A. bisporus can be used for anticancer therapy as it is easily available and inexpensive (Chen et al, 2006). This species also shows neuroprotective activity and could be used for prophylaxis of neurodegenerative diseases (Rai et al, 2021).…”
Section: Introductionmentioning
confidence: 99%