Therapeutic applications of selenium nanoparticles

Khurana, Amit; Tekula, Sravani; Saifi, Mohd Aslam; Pooladanda, Venkatesh; Godugu, Chandraiah

doi:10.1016/j.biopha.2018.12.146

Cited by 601 publications

(436 citation statements)

References 97 publications

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“…Based on the results obtained from pancreatic enzyme secretions, biochemical parameters, histopathology, and immunostaining, we report that crocin is effective in protecting the pancreas from cerulein‐induced AP and regular intake of saffron in diet can significantly reduce the risk of AP. In future, novel formulations for the delivery of crocin may improve the chances of clinical translation of crocin (Khurana & Godugu, ; Khurana, Tekula, Saifi, Venkatesh, & Godugu, ).…”

Section: Discussionmentioning

confidence: 99%

Crocin, an active constituent of Crocus sativus ameliorates cerulein induced pancreatic inflammation and oxidative stress

Godugu

Pasari

Khurana

et al. 2019

Phytotherapy Research

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Acute pancreatitis (AP) is a disorder of the pancreas marked by profound inflammation and oxidative stress. Phytoconstituents presents an important toolbox of preventive strategies to combat inflammatory disorders. To this end, we selected the active constituent of Crocus sativus, crocin for evaluation against cerulein‐induced AP, owing to its promising antiinflammatory activity in acute as well as chronic inflammatory conditions. The animals were randomly divided into five groups comprising of normal control, cerulein control, crocin low dose (30 mg/kg), crocin high dose (100 mg/kg), and crocin control (100 mg/kg). Various biochemical parameters and the levels of inflammatory cytokines and p65‐NFκB were measured. The mechanism was investigated by histology and immunohistochemistry. We found that crocin significantly reduced the pancreatic edema, amylase, and lipase levels. It abrogated the oxidative stress incurred by cerulein challenge. We found that crocin modulated the pancreatic inflammatory cytokine levels. Crocin perturbed the nuclear translocation of p65‐NFκB. Crocin reverted the pancreatic histology associated with AP. Furthermore, it upregulated the expression of Nrf‐2 and downregulated the expression of IL‐6, TNF‐α, nitrotyrosine, and NFκB. Cumulatively, these results indicate that crocin has promising potential to prevent cerulein induced AP and regular intake of saffron can prove beneficial for the pancreatic health.

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Section: Discussionmentioning

confidence: 99%

Crocin, an active constituent of Crocus sativus ameliorates cerulein induced pancreatic inflammation and oxidative stress

Godugu

Pasari

Khurana

et al. 2019

Phytotherapy Research

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“…In this regard, different metallic nanoparticles (NPs) including silver (Ag) [4][5][6], gold (Au) [7], zinc (Zn) [8], selenium (Se) [9,10], titanium [11], ceria [12] have been explored [13]. Se is an essential metalloid element that has been extensively used in medical applications owing to its antioxidative, antimicrobial and antitumor activities [14]. Unlike other metallic NPs, Se is required by humans in trace amounts as a micronutrient.…”

Section: Introductionmentioning

confidence: 99%

Phytogreen synthesis of multifunctional nano selenium with antibacterial and antioxidant implications

et al. 2020

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The exploitation of plant extracts for the synthesis of nano selenium having antibacterial and antioxidant activities is an exciting approach to counteract the prevalence of infections caused by antibiotic-resistant bacteria, which holds relevance for medical and food industries. In the present work, a green and facile method for the preparation of nano selenium (nSe) using the fruit extract of Indian gooseberry (Phyllanthus Emblica) has been reported. The optical and structural properties of the as-synthesized nSe were studied through various characterization techniques. Eventually, the antioxidant potential of nSe was investigated via 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl free radical scavenging assays. Parallely, the antibacterial activity of nSe against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa was evaluated. The antioxidant assays indicated that even low dosage of nSe showed excellent activity with EC 50 values of 0.21 μg ml −1 and 3.34 μg ml −1 , respectively. Moreover, nSe exhibited significant inhibition in bacterial growth at low minimum inhibitory concentration (MIC) values against Escherichia coli (16 μg ml −1 ), Staphylococcus aureus (32 μg ml −1 ) and Pseudomonas aeruginosa (48 μg ml −1 ) compared to MIC values for standard drug ampicillin. Importantly, nSe did not induce any cytotoxic effects on normal human keratinocytes (HaCaT) at the tested concentrations; representing their biocompatible nature. The data obtained demonstrated the versatility of phytogreen nSe as a potent antioxidant and antibacterial agent to effectively prevent as well as treat multidrug-resistant bacterial infections.

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“…In addition, detailed toxicological studies are necessary to decide the clinical future of this novel plant and its various active constituents as safety is a critical concern during clinical development of plant‐based medicines (Izzo, Hoon‐Kim, Radhakrishnan, & Williamson, ). In addition, physiological and biopharmaceutical parameters are often the bottleneck in the clinical translation of plant‐based medicines, which may be addressed by using various novel formulation‐based strategies (Bale, Khurana, Reddy, Singh, & Godugu, ; Godugu, Kumari, & Khurana, ; Khurana et al, ; Khurana, Saifi, & Godugu, ; Khurana, Tekula, Saifi, Venkatesh, & Godugu, ).…”

Section: Resultsmentioning

confidence: 99%

Modulation of cerulein‐induced pancreatic inflammation by hydroalcoholic extract of curry leaf (Murraya koenigii)

Khurana

Sikha

Ramesh

et al. 2019

Phytotherapy Research

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This study was performed to study the in vitro and in vivo efficacy of hydroalcoholic extract of curry leaf (CLE) rich in carbazole alkaloids, against LPS‐induced inflammation in Raw 264.7 macrophages and cerulein‐induced acute pancreatitis, respectively. CLE was characterized by Fourier‐transform infrared (FTIR) and liquid chromatography–mass spectrometry. Raw 264.7 cells were stimulated with LPS (2 μg/ml) and treated with CLE. The animals were treated with two doses of CLE (100 and 300 mg/kg). Plasma biochemistry, tissue lipid peroxidation, cytokines, and histological examination were evaluated. CLE was found to decently scavenge the activity of DPPH radical. It dose dependently suppressed nitrite production and oxidative stress in macrophages. CLE alleviated LPS‐induced inflammation in macrophages as evident from the results of various inflammatory cytokines (IL‐1β, IL‐6, and TNF‐α). In vivo, CLE reduced cerulein‐induced pancreatic edema. CLE significantly abrogated the cerulein‐induced lipid peroxidation, nitrite, MPO, and GSH levels. The inflammatory cytokines and p65‐NFκB activity were significantly reduced by CLE. Mechanistically, CLE reduced the expression of NT, MPO, IL‐1β, ICAM‐1, and COX‐2, and increased the expression of Nrf2. It reduced distant organ damage markers as well. We report for the first time that CLE holds substantial potential for the prevention of acute pancreatitis.

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Therapeutic applications of selenium nanoparticles

Cited by 601 publications

References 97 publications

Crocin, an active constituent of Crocus sativus ameliorates cerulein induced pancreatic inflammation and oxidative stress

Crocin, an active constituent of Crocus sativus ameliorates cerulein induced pancreatic inflammation and oxidative stress

Phytogreen synthesis of multifunctional nano selenium with antibacterial and antioxidant implications

Modulation of cerulein‐induced pancreatic inflammation by hydroalcoholic extract of curry leaf (Murraya koenigii)

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