Therapeutic approaches for celiac disease

Abstract

Celiac disease is a common, lifelong autoimmune disorder for which dietary control is the only accepted form of therapy. A strict gluten-free diet is burdensome to patients and can be limited in efficacy, indicating there is an unmet need for novel therapeutic approaches to supplement or supplant dietary therapy. Many molecular events required for disease pathogenesis have been recently characterized and inspire most current and emerging drug-discovery efforts. Genome-wide association studies (GWAS) confirm the importance of human leukocyte antigen genes in our pathogenic model and identify a number of new risk loci in this complex disease. Here, we review the status of both emerging and potential therapeutic strategies in the context of disease pathophysiology. We conclude with a discussion of how genes identified during GWAS and follow-up studies that enhance susceptibility may offer insight into developing novel therapies.

Celiac Disease

“…107 More nondietary options are likely to become available as our understanding of the pathophysiology of CD increases. 108 Different targets in the pathophysiology of CD have been identified in clinical and preclinical trials as potential nondietary therapies (reviewed elsewhere [109][110][111] ). The potential to induce tolerance to gluten in patients with CD with epitope-specific immunotherapy targeting T cells is exciting and a potentially remarkable discovery.…”

Diagnosis dan Tata Laksana Penyakit Celiac

“…1 Prevalensi penyakit celiac di dunia terutama di negara barat diperkirakan sekitar 0,5-1%. 2,3 Namun demikian, penyakit ini jarang ditemukan di negara dengan konsumi gluten rendah, seperti Indonesia, Korea, Filipina, dan pulau-pulau kecil di Pasifik. 4,5 Penyakit celiac memiliki manifestasi klinis yang beragam dan dapat terjadi pada berbagai usia.…”

“…Banyak dari pilihan pengobatan tersebut sudah mencapai uji klinik, namun belum satu pun tersedia untuk penggunaan di praktik klinik. 3,5,16,23…”

La Dieta Sin Gluten Y Los Alimentos Libres De Gluten

“…Su único tratamiento eficaz es la dieta libre de gluten (DLG) (3,11), mantenida de manera estricta y por toda la vida (tabla 1). Aunque despiertan gran interés entre los celíacos, hasta ahora no hay opciones de tratamientos no dietarios (12). Por otro lado y salvo excepciones (casos refractarios), tampoco hay terapia medicamentosa.…”