Therapeutic approaches for patients with coexisting familial adenomatous polyposis and colorectal cancer

Inoue, Yasuhiro; Ishida, Hideyuki; Ueno, Hideki; Kobayashi, Hirotoshi; Yamaguchi, Tatsuro; Konishi, Tsuyoshi; Tomita, Naohiro; Matsubara, Nagahide; Ishida, Fumio; Hinoi, Takao; Kanemitsu, Yukihide; Watanabe, Toshiaki; Sugihara, Kenichi

doi:10.1093/jjco/hyw086

Cited by 9 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, metachronous rectal cancer was the most common cause of death. In previous studies, the surveillance period was approximately 5-10 years, and long-term prognosis of metachronous rectal cancer remains unknown (11,(14)(15)(16)(17). In our study, the median surveillance period was 169 months.…”

Section: Discussionmentioning

confidence: 61%

See 1 more Smart Citation

Long-term Prognostic Impact of Metachronous Rectal Cancer in Patients With Familial Adenomatous Polyposis: A Single-center Retrospective Study

Tatsuta

Sakata

Iwaizumi

et al. 2023

CDP

View full text Add to dashboard Cite

Aim: To evaluate the risk factors and long-term prognosis of metachronous rectal cancer in the remnant rectum of patients with familial adenomatous polyposis (FAP). Patients and Methods: Sixty-five patients (49 families) who underwent prophylactic surgery, including bowel resection, for FAP between January 1976 and August 2022 at Hamamatsu University Hospital were included and divided into two groups based on the presence of metachronous rectal cancer. Risk factors for metachronous rectal cancer development were analysed in cases treated with total colectomy with ileorectal anastomosis (IRA) and stapled total proctocolectomy with ileal pouch anal anastomosis (IPAA) (IRA, n=22; stapled IPAA n=20; total, n=42). Results: The median surveillance period was 169 months. Twelve patients developed metachronous rectal cancer (IRA, n=5; stapled IPAA, n=7), of which six with advanced cancer died. Patients who temporarily dropped out of surveillance were significantly more likely to have metachronous rectal cancer (metachronous vs. non-metachronous rectal cancer: 33.3% vs. 1.9%, p<0.01). The mean duration of surveillance suspension was 87.8 months. Cox regression analysis revealed that temporary surveillance drop-out independently affected the risk (p=0.04). The overall survival associated with metachronous rectal cancer was 83.3% at 1 year and 41.7% at 5 years. Overall survival was significantly worse in advanced cancer than in early cancer cases (p<0.01). Conclusion: Temporary drop-out from surveillance was a risk factor for metachronous rectal cancer development, and advanced cancer had a poor prognosis. Continuous surveillance of patients with FAP, without temporary drop-out, is strongly recommended.

show abstract

Section: Discussionmentioning

confidence: 61%

“…The findings of this study can be expected to substantially impact the recommendations of surveillance for FAP. In the past, CRC was the most common reason for death in patients with FAP (14,15). Metachronous rectal cancer after IRA was reported to account for nearly one-fifth of FAP-related causes of death (16).…”

Section: Discussionmentioning

confidence: 99%

Long-term Prognostic Impact of Metachronous Rectal Cancer in Patients With Familial Adenomatous Polyposis: A Single-center Retrospective Study

Tatsuta

Sakata

Iwaizumi

et al. 2023

CDP

View full text Add to dashboard Cite

show abstract

“…FAP was classified into the following three types according to the number of colorectal adenomas: profuse type (>1,000), sparse type (between 100 and 1,000), and attenuated type (between 10 and 99) [8]. The details of the treatment were reported previously [16]; the most common procedure for FAP was restorative proctocolectomy with ileal pouch anal anastomosis, irrespective of the phenotype.…”

Section: Original Data Sources and Patient Selectionmentioning

confidence: 99%

Morphological Analyses of Colorectal Adenocarcinomas in Japanese Familial Adenomatous Polyposis Patients

Suzuki

Ishida²,

Ishida

et al. 2022

J Anus Rectum Colon

Self Cite

View full text Add to dashboard Cite

Objectives: This retrospective study was conducted to clarify the morphological characteristics of colorectal cancer (CRC) in Japanese familial adenomatous polyposis (FAP) patients. Methods: This study was carried out by the study group for FAP of the Japanese Society for Cancer of the Colon and Rectum. FAP patients who underwent surgical resection between 2000 and 2012 were included in the study. Results: Of the 303 patients enrolled, 119 patients without CRC were excluded. Of 523 lesions, 49 lesions with missing morphological information were excluded; hence, only 474 CRC lesions in 178 patients (328 superficial lesions in 122 patients and 146 non-superficial lesions in 92 patients) were included in the study. Depressed lesions accounted for 3.0% of superficial lesions and ulcerated lesions accounted for 84.9% of non-superficial lesions. The depressed superficial lesions were observed only in patients with sparse and attenuated FAP (P = 0.003). The age of the patients at surgery differed between the two groups, with patients with depressed superficial lesions being significantly older than those with non-depressed superficial lesions (P = 0.009). Moreover, the age of the patients at FAP diagnosis differed between the two groups, with patients with ulcerated non-superficial lesions being significantly older than those with protruded nonsuperficial lesions (P = 0.006). Conclusions: In patients with FAP, depressed superficial CRC lesions rarely developed but were detected in our study group, and ulcerated non-superficial CRC lesions were also present with similar ratios. Clinicians should pay attention to depressed superficial lesions during endoscopic surveillance of FAP patients.

show abstract

Long-term prognosis of familial adenomatous polyposis with or without mucosectomy

Tatsuta

Sakata

Morita

et al. 2022

Int J Colorectal Dis

View full text Add to dashboard Cite

Therapeutic approaches for patients with coexisting familial adenomatous polyposis and colorectal cancer

Cited by 9 publications

References 26 publications

Long-term Prognostic Impact of Metachronous Rectal Cancer in Patients With Familial Adenomatous Polyposis: A Single-center Retrospective Study

Long-term Prognostic Impact of Metachronous Rectal Cancer in Patients With Familial Adenomatous Polyposis: A Single-center Retrospective Study

Morphological Analyses of Colorectal Adenocarcinomas in Japanese Familial Adenomatous Polyposis Patients

Long-term prognosis of familial adenomatous polyposis with or without mucosectomy

Contact Info

Product

Resources

About