Therapeutic Approaches to Nociplastic Pain Based on Findings in the Reserpine-Induced Fibromyalgia-Like Animal Model

Abstract

ABBREVIATIONS: AMPA, α-3-hydroxy-5-methyl-4-isoxazole propionic acid; ASIC, acid-sensing ion channel; ATP, adenosine triphosphate; AT -RvD1, aspirin-triggered resolvin D1; AT -RvD2, aspirin-triggered resolvin D2; BBG, brilliant blue G; 2-BFI, 2-(2-Benzofuranyl)-2-imidazoline; CaMKII, calmodulin-dependent protein kinase II; CAT, catalase; CNS, central nervous system; CoQ10, coenzyme Q10; CSF, cerebrospinal fluid; Cox, cyclooxygenase; DA, dopamine; DALBk, des-Arg 9 -[Leu 8 ]bradykinin; DRG, dorsal root of ganglia; EEG, electroencephalography; EPM, elevated plus maze; EZM, elevated zero maze; FM, fibromyalgia; FST, forced swimming test; GSH, glutathione; 5-HT, 5-hydroxytryptamine (serotonin); FAAH, fatty acid amide hydrolase; GABA, γ-aminobutyric acid; GluN2B, NMDA-type glutamate receptor subunit 2B; 11β-HA, hyperalgesia; HS, hypersensitivity; HSD, 11β-hydroxysteroid dehydrogenase; IASP, the International Association for the Study of Pain; IL, interleukin; iNOS, inducible nitric oxide synthase; KCC2, K + -Clco-transporter 2; LA, locomotor activity; LPO, lipid peroxide; MA, mechanical allodynia; MAO, monoamine oxidase; (m-CF3-PhSe) 2 , m-trifluoromethyl-diphenyl diselenide; MDA, malondialdehyde; Mfn, mitofusin; MWM, Morris water maze; NA, noradrenaline; Nav, voltage-dependent Na + channel; NF-κB, nuclear factor-κB; NGF, nerve growth factor; NLRP, nucleotide-binding oligomerization domain (NOD)-like receptor protein;