Therapeutic associated with occupational exposure to silica

Raghuvanshi, Suchita; Shrivastava, Sadhana; Johri, Sonia; Shukla, Sangeeta

doi:10.1016/j.jtemb.2012.04.006

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…Human studies have produced contradictory results. Stone workers in the Gwalior region exposed to silica dust had increased serum ACE level [ 23 ]. Increased serum ACE activities were reported in silicosis patients compared to control subjects, but this activity did not reflect the severity of the disease as determined by chest x-ray changes and respiratory function tests, did not give further information on the progression of the disease [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Copper, Ceruloplasmin and Angiotensin Converting Enzyme among Silicotic and Non-Silicotic Workers

Beshir

Aziz

Shaheen

et al. 2015

Open Access Maced J Med Sci

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BACKGROUND:Silicosis is the most frequently occurring pneumoconiosis.AIM:Measurement of serum levels of Angiotensin converting enzyme (ACE), Copper (Cu) and Ceruloplasmin (Cp) in cement workers occupationally exposed to silica dust as biomarkers of exposure rather than biomarkers of effect for silicosis.METHODS:Plain chest X-ray & pulmonary functions were done for 30 silicotic and 42 non-silicotic workers and 42 controls. CT scan was done for the exposed groups. Serum levels of Cu, Cp and ACE were estimated.RESULTS:The results showed a higher significant difference between the exposed groups and controls, and between the two exposed groups regarding the mean levels of all measured biochemical parameters. The pulmonary functions were significantly lower among silicotic workers than controls and non-silicotic groups. There was a significant positive correlation between duration of employment and serum ACE and Cu.CONCLUSION:Since respirable dust exposure-linked lung fibrosis disease is non-curable, the biochemical parameters (Cu, ACE and Cp) can be used as exposure biomarkers to silica dust, providing a better way for early diagnosis of this deadly disease. Down regulating the inflammatory responses could potentially reduce the adverse clinical pulmonary effects of air pollution.

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Section: Discussionmentioning

confidence: 99%

Serum Levels of Copper, Ceruloplasmin and Angiotensin Converting Enzyme among Silicotic and Non-Silicotic Workers

Beshir

Aziz

Shaheen

et al. 2015

Open Access Maced J Med Sci

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“…Cement dust exposure is considered as one of the most hazardous occupational exposures in the world (Ogunbileje et al, 2014). Cement dust contains various compounds including calcium oxide (CaO), silicon dioxide (SiO 2 ), aluminum trioxide (Al 2 O 3 ), iron oxide (Fe 2 O 3 ), magnesium oxide (MgO), crystalline silica, sulfur oxide (Hemmati et al, 2008; Keshavarzi et al, 2019; Malekirad et al, 2019; Raghuvanshi et al, 2012; ), and toxic elements such as Aluminum (Al) and Chromium (Cr) (Ferrante and Conti, 2017; Pandey and Jain, 2013). Occupational exposure to cement dust has been reported to cause adverse effects such as liver, neurological, lung, heart and spleen disorders (Ansari et al, 2007; Cohen et al, 2014; Meo et al, 2013; Vuorio et al, 1989; ), and oxidative stress (Orman et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of oxidative stress and biochemical biomarkers, and psychological parameters in cement plant workers

et al. 2022

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The cement industry is one of the main world industries with exposure to a wide range of hazardous chemical and physical occupational agents that may increase free radicals and lead to disease. The aim of this study was to evaluate oxidative stress, biochemical markers, and psychological parameters among cement plant workers. In this cross-sectional study, 40 workers exposed to cement and 40 office employees were selected as the exposed and non-exposed groups, respectively. Exposure to cement dust, silica, and noise were, respectively, assessed using the NIOSH 0600, NIOSH 7601, and noise dosimetry methods. Oxidative stress biomarkers including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), total antioxidant capacity (TAC), and biochemical parameters were measured in the serum of all participants. Depression, anxiety, and stress were assessed by the Depression Anxiety Stress Scales (DASS-21) questionnaire. The results demonstrated that the level of MDA as a marker of oxidative stress was significantly higher in the exposed group. The level of antioxidant enzymes including SOD and CAT were also significantly higher in the exposed group. The level of TAC was lower in the exposed group, but the difference was not statistically significant. The levels of alkaline phosphatase (ALP), aspartate transaminase (AST), and the scores of depression and stress were also significantly higher in the exposed group. According to our results, noise, cement dust, and silica exposure were associated with oxidative stress, and this may be one of the mechanisms in which they adversely affect liver function and mental health.

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“…The cement industry has recently grown enormously, especially in developing countries. Exposure to cement dust is known as one of the most hazardous occupational exposures in the world [1].Cement dust contains various compounds including calcium oxide (CaO), silicon dioxide(SiO 2 ), aluminum trioxide(Al 2 O 3 ), iron oxide(Fe 2 O 3 ), magnesium oxide (MgO), crystalline silica, sulfur oxide [2][3][4][5]and toxic elements such as Aluminum(Al) and Chromium (Cr) [6,7]. Occupational exposure to cement dust has been reported to cause adverse effects such as liver, neurological, lung, heart and spleen disorders [8][9][10][11], and oxidative stress [12].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Oxidative Stress and Biochemical Biomarkers, and Psychological Parameters in Cement Plant Workers

Darabi¹,

Keshavarzi²,

Abdullah³

et al. 2020

Preprint

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BackgroundThe cement industry is one of the main world industries with exposure to a wide range of hazardous chemical and physical occupational agents that can increase free radicals and cause diseases. The aim of this study was to evaluate oxidative stress, and biochemical markers and psychological parameters among cement plant workers who were exposed to variety of hazardous occupational agents.MethodsIn this cross-sectional study 40 workers exposed to cement and 40 office employees, were selected as the exposed and control group, respectively. Exposure to cement dust, silica and noise were respectively assessed using the NIOSH 0600, NIOSH 7601 and noise dosimetry methods. Oxidative stress biomarkers including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), total antioxidant capacity (TAC), and biochemical parameters were measured in the serum of all participants. Depression, anxiety and stress were assessed by Depression Anxiety Stress Scales (DASS-21) questioner. Statistical analysis was performed by SPSS22 software. Independent t-test, Mann-Whitney U, Chi-square were used to evaluate the relation between variables. ResultsThe results demonstrated that the level of MDA as a marker of oxidative stress was significantly higher in the exposed group.Antioxidant enzymes including SOD and CAT were significantly higher, and TAC was insignificantly lower in the exposed group. Alkaline phosphatase (ALP), aspartate transaminase (AST), depression and stress were also significantly higher in the exposure group. It seems like working in cement plants, can have hazardous effects on liver function, enzyme activity and mental health.

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Therapeutic associated with occupational exposure to silica

Cited by 6 publications

References 31 publications

Serum Levels of Copper, Ceruloplasmin and Angiotensin Converting Enzyme among Silicotic and Non-Silicotic Workers

Serum Levels of Copper, Ceruloplasmin and Angiotensin Converting Enzyme among Silicotic and Non-Silicotic Workers

Evaluation of oxidative stress and biochemical biomarkers, and psychological parameters in cement plant workers

Evaluation of Oxidative Stress and Biochemical Biomarkers, and Psychological Parameters in Cement Plant Workers

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