Therapeutic battle against larval toxocariasis: Are we still far behind?

Othman, Ahmad A.

doi:10.1016/j.actatropica.2012.08.003

Cited by 56 publications

(51 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the immunopathological response may differ among patients and symptoms and signs may undergo remission in treated and placebo-treated patients. Therefore, the dose rates of drugs and length of treatment differ among patients (Othman 2012).…”

Section: Medical Treatmentmentioning

confidence: 99%

Ocular toxocariasis: a neglected parasitic disease in Egypt

El-Sayed

Masoud

2019

Bull Natl Res Cent

View full text Add to dashboard Cite

Background: Ocular toxocariasis is considered a parasitic disease of major socioeconomic importance. In spite of the high prevalence of human toxocariasis (up to 84%) among Egyptian patients, the incidence of ocular toxocariasis is underestimated. The recognition of this neglected disease would be the initial step to overcome it. Thus, this review gave updated information on the pathogenesis, clinical manifestations, diagnosis, and treatment of ocular toxocariasis. Results: Ocular toxocariasis is an important cause of unilateral vision impairment mostly in children and always in the differential diagnosis of retinoblastoma. This disease exhibits various manifestations such as posterior pole granuloma, peripheral granuloma, or chronic endophthalmitis. Diagnosis of ocular toxocariasis can be carried out by the ophthalmic examination and immunodiagnostic methods to reveal the specific antibodies in serum and ocular fluids. In addition, molecular diagnosis, medical imaging techniques, and histopathologic observation of Toxocara larva in the surgically obtained specimens can be performed. Ocular toxocariasis can be treated either medically or surgically. Regarding medical treatment, the ophthalmologists prefer to use steroids and anthelminthic drugs; however, there are no standardized parameters for doses, duration, and route of administration. Conclusion: Clinical suspicion plays a leading role in the diagnosis of ocular toxocariasis, but always with other diagnostic methods. Accurate diagnosis and prompt treatment can minimize ocular morbidity.

show abstract

Section: Medical Treatmentmentioning

confidence: 99%

Ocular toxocariasis: a neglected parasitic disease in Egypt

El-Sayed

Masoud

2019

Bull Natl Res Cent

View full text Add to dashboard Cite

show abstract

“…Ocular toxocariasis is associated with vision loss, especially among children living in the South [21]. Given the high rates of toxocariasis among people living in the southern US and its association with cognitive delays, epilepsy, vision loss, and reduced pulmonary function, there is an urgent need to conduct prospective studies to confirm these links as well as to evaluate potential therapies with albendazole and other anthelminthic drugs [22]. The extent to which other soil-transmitted helminth infections still occur in the US is not known.…”

Section: Neglected Helminthic Infectionsmentioning

confidence: 99%

Neglected Parasitic Infections and Poverty in the United States

Hotez

2014

PLoS Negl Trop Dis

View full text Add to dashboard Cite

“…Some authors agree that treatment is needed when patients' symptoms are severe. 13,23,24 In ELA-T was simultaneously identified and pathologically confirmed in one case with renal cell carcinoma at the time of initial diagnosis; in this patient, effect of cancer or surgery on the development and outcome of ELA-T could not be ruled out.…”

Section: -47mentioning

confidence: 99%

“…23 Treatment of ELA-T depends on the severity of the patient's symptoms and the clinician's decision. Some authors agree that treatment is needed when patients' symptoms are severe.…”

Section: -47mentioning

confidence: 99%

Enhanced Resolution of Eosinophilic Liver Abscess Associated with Toxocariasis by Albendazole Treatment

Jang

Choi

Gwak

et al. 2015

Korean J Gastroenterol

View full text Add to dashboard Cite

Background/Aims: Visceral larva migrans, caused by Toxocara canis and Toxocara cati, has emerged as a significant cause of eosinophilic liver abscess (ELA). Differentiation of ELA associated with toxocariasis (ELA-T) from metastasis or primary liver malignancy is sometimes difficult. However, the role of albendazole treatment remains uncertain in this condition. The aim of this study was to evaluate whether albendazole can enhance the radiologic resolution of ELA-T. Methods: We retrospectively reviewed the medical records of the patients diagnosed with ELA-T at our institution between January 2008 and December 2011. ELA-T was diagnosed based on the imaging findings on computed tomography or magnetic resonance imaging and the presence of positive serum IgG antibody for Toxocara canis. Among a total of 163 patients, 32 patients received albendazole (albendazole group) and 131 did not (control group). Baseline characteristics and fate of liver nodules were compared between the two groups. Results: Baseline characteristics (age, sex, number and maximal size of lesions, eosinophil count) were similar between the two groups. Median duration for achieving radiologic resolution in the albendazole group was significantly shorter than in the control group (207 days [range 186-228] vs. 302 days [range 224-380], p=0.023). In Cox regression analysis of the cumulative rates of radiologic resolution, the hazard ratio for albendazole treatment was 1.99 (95% confidence interval, 1.22-3.23). Conclusions: Radiologic resolution of ELA-T can be accelerated with albendazole treatment. Hence, inconvenience associated with long-term follow-up and unnecessary worries among patients can be eliminated with albendazole treatment. (Korean J Gastroenterol 2015;65:222-228)

show abstract

Therapeutic battle against larval toxocariasis: Are we still far behind?

Cited by 56 publications

References 59 publications

Ocular toxocariasis: a neglected parasitic disease in Egypt

Ocular toxocariasis: a neglected parasitic disease in Egypt

Neglected Parasitic Infections and Poverty in the United States

Enhanced Resolution of Eosinophilic Liver Abscess Associated with Toxocariasis by Albendazole Treatment

Contact Info

Product

Resources

About