Therapeutic Benefits from Nanoparticles: The Potential Significance of Nanoscience in Diseases with Compromise to the Blood Brain Barrier

Krol, Silke; Macrez, Richard; Docagne, Fabián; Defer, Gilles; Laurent, Sophie; Rahman, Mohammad Rezaur; Hajipour, Mohammad Javad; Kehoe, Patrick Gavin; Mahmoudi, Morteza

doi:10.1021/cr200472g

Cited by 189 publications

(140 citation statements)

References 408 publications

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“…It will also seem evident that when given in vivo the particles will be cleared and probably be deposited as iron stores inside cells of the brain, most likely in ferritin that forms a major repository for iron in both neurons and glia capable of binding approximately 4500 atoms of iron per ferritin molecule. 25,26 Integrity of the BCECs Forming an in Vitro BBB. The effect of SPIONs was further investigated by monitoring the integrity of the BCECs before and after application of SPIONs followed by exposure to a magnetic force.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Uptake and Transport of Superparamagnetic Iron Oxide Nanoparticles through Human Brain Capillary Endothelial Cells

Thomsen

Linemann

Pondman

et al. 2013

ACS Chem. Neurosci.

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ABSTRACT:The blood−brain barrier (BBB) formed by brain capillary endothelial cells (BCECs) constitutes a firm physical, chemical, and immunological barrier, making the brain accessible to only a few percent of potential drugs intended for treatment inside the central nervous system. With the purpose of overcoming the restraints of the BBB by allowing the transport of drugs, siRNA, or DNA into the brain, a novel approach is to use superparamagnetic iron oxide nanoparticles (SPIONs) as drug carriers. The aim of this study was to investigate the ability of fluorescent SPIONs to pass through human brain microvascular endothelial cells facilitated by an external magnet. The ability of SPIONs to penetrate the barrier was shown to be significantly stronger in the presence of an external magnetic force in an in vitro BBB model. Hence, particles added to the luminal side of the in vitro BBB model were found in astrocytes cocultured at a remote distance on the abluminal side, indicating that particles were transported through the barrier and taken up by astrocytes. Addition of the SPIONs to the culture medium did not negatively affect the viability of the endothelial cells. The magnetic force-mediated dragging of SPIONs through BCECs may denote a novel mechanism for the delivery of drugs to the brain.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Uptake and Transport of Superparamagnetic Iron Oxide Nanoparticles through Human Brain Capillary Endothelial Cells

Thomsen

Linemann

Pondman

et al. 2013

ACS Chem. Neurosci.

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“…One may speculate, for instance, that the observed increase of the apolipoproteins in the corona may promote prolonged circulation time in the bloodstream, based on prior literature of apolipoprotein effects on drug delivery. 27 One might also suspect that the changes plasmonic heating induced in the apolipoprotein A-II precursor concentration in the AuNR protein corona could make AuNRs less likely to cross specific biological barriers (e.g., blood brain barrier 31 ) following hyperthermia treatment. As shown previously through MRI tests on a brain capillary endothelial cell in the presence of magnetic NPs with apolipoproteins in their corona composition, 31 apolipoproteins are important in mediating NP transport through the blood brain barrier.…”

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confidence: 99%

Variation of Protein Corona Composition of Gold Nanoparticles Following Plasmonic Heating

et al. 2013

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It is well recognized that the primary interaction of most biological environments with nanoparticles (NPs) is strongly influenced by a long-lived ("hard") protein corona that surrounds the NP and remains strongly adsorbed to its surface. The amount and composition of associated proteins in the corona adsorbed onto the NPs is related to several important factors, including the physicochemical properties of the NPs and the composition of the protein solution. Here, for the first time, it is shown that plasmonic heat induction (by laser activation) leads to significant changes in the composition of the hard protein corona adsorbed on low aspect ratio gold nanorods. Using mass spectrometry, several proteins in the corona were identified whose concentrations change most substantially as a result of photoinduced (plasmonic) heating versus simple thermal heating. Molecular modeling suggests that the origin of these changes in protein adsorption may be the result of protein conformational changes in response to much higher local temperatures that occur near the gold nanorods during photoinduced, plasmonic heating. These results may define new applications in vivo for NPs with hyperthermia capability and better define the likely interactions of cells with NPs after plasmonic heating. Potential changes in the protein corona following hyperthermia treatment may influence the final biological fate of plasmonic NPs in clinical applications and help elucidate safety considerations for hyperthermia applications.

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“…63 Due to blood brain barrier (BBB), there are many challenges associated with the early detection and treatment of brain tumor. 64 In order to detect the pre-angiogenic and brain tumors at the early stages, it is required to fabricate NPs capable of penetrating the defense barriers. Cao et al, 65 synthesized magnetoferritin NPs capable of transport through the endothelium, epithelium and BBB via clathrin-mediated endocytosis and specifically detected the tumor cells which expressed the transferrin receptor 1.…”

Section: Brain Tumorsmentioning

confidence: 99%

Targeted superparamagnetic iron oxide nanoparticles for early detection of cancer: Possibilities and challenges

Bakhtiary

Saei

Hajipour

et al. 2016

Nanomedicine: Nanotechnology, Biology and Medicine

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152

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Nanomedicine, the integration of nanotechnological tools in medicine demonstrated promising potential to revolutionize the diagnosis and treatment of various human health conditions. Nanoparticles (NPs) have shown much promise in diagnostics of cancer, especially since they can accommodate targeting molecules on their surface, which search for specific tumor cell receptors upon injection into the blood stream. This concentrates the NPs in the desired tumor location. Furthermore, such receptor-specific targeting may be exploited for detection of potential metastases in an early stage. Some NPs, such as superparamagnetic iron oxide NPs (SPIONs), are also compatible with magnetic resonance imaging (MRI), which makes their clinical translation and application rather easy and accessible for tumor imaging purposes. Furthermore, multifunctional and/or theranostic NPs can be used for simultaneous imaging of cancer and drug delivery. In this review article, we will specifically focus on the application of SPIONs in early detection and imaging of major cancer types.From the Clinical Editor: Super-paramagnetic iron oxide nanoparticles (SPIONs) have been reported by many to be useful as an MRI contrast agent in the detection of tumors. To further enhance the tumor imaging, SPIONs can be coupled with tumor targeting motifs. In this article, the authors performed a comprehensive review on the current status of using targeted SPIONS in tumor detection and also the potential hurdles to overcome. © 2015 Elsevier Inc. All rights reserved. 1 A significant improvement in cancer survival has been noted over the past three decades for most cancer types. This notable and continuous decrement in tumor fatality is related to advanced development in prevention, early diagnosis and therapeutic approaches and decrease in overall prevalence of smoking.1 Early detection of cancer, especially before cancer cells metastasize, is critical for cancer diagnosis, because early stage cancers can be treated more effectively. However, early-stage diagnosis has been difficult to achieve in most cases since clinical symptoms tend to show up at later stages. Therefore, minimally-and non-invasive methods for early detection of cancer are urgently needed in the field. In this regard, many SPION-based systems are under development for more sensitive imaging and earlier detection of tumors. Since non-targeted SPION species cannot readily differentiate cancer tissues from normal tissues, second-generation SPIONs have been developed which are equipped with targeting moieties that can recognize Nanomedicine: Nanotechnology, Biology, and Medicine 12 (2016) 287 -307

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Therapeutic Benefits from Nanoparticles: The Potential Significance of Nanoscience in Diseases with Compromise to the Blood Brain Barrier

Cited by 189 publications

References 408 publications

Uptake and Transport of Superparamagnetic Iron Oxide Nanoparticles through Human Brain Capillary Endothelial Cells

Uptake and Transport of Superparamagnetic Iron Oxide Nanoparticles through Human Brain Capillary Endothelial Cells

Variation of Protein Corona Composition of Gold Nanoparticles Following Plasmonic Heating

Targeted superparamagnetic iron oxide nanoparticles for early detection of cancer: Possibilities and challenges

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