Therapeutic Capsule Endoscopy: Opportunities and Challenges

Rasouli, Mahdi; Lin, Lin; Kencana, Andy Prima; Wong, Kai-Juan; Tan, Soon Keat; Ho, Khek Yu; Phee, Soo Jay

doi:10.1260/2040-2295.2.4.459

Cited by 10 publications

(6 citation statements)

References 34 publications

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“…It usually deploys leg-like mechanisms [ 32 , 33 , 34 , 40 , 50 , 55 ] or uses a magnetic field [ 56 , 57 ] to attach the capsule to the inner wall of the GI tract. The release mechanism is triggered to deliver drugs in a controlled manner and involves a reservoir [ 12 , 40 , 58 ] with release triggered by specific environmental conditions, e.g., temperature or pH [ 50 ], or by activation of a magnetic field [ 56 ].…”

Section: Capsule Endoscopymentioning

confidence: 99%

Acoustic Sensing and Ultrasonic Drug Delivery in Multimodal Theranostic Capsule Endoscopy

Stewart

Qiu

Lay

et al. 2017

Sensors

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Video capsule endoscopy (VCE) is now a clinically accepted diagnostic modality in which miniaturized technology, an on-board power supply and wireless telemetry stand as technological foundations for other capsule endoscopy (CE) devices. However, VCE does not provide therapeutic functionality, and research towards therapeutic CE (TCE) has been limited. In this paper, a route towards viable TCE is proposed, based on multiple CE devices including important acoustic sensing and drug delivery components. In this approach, an initial multimodal diagnostic device with high-frequency quantitative microultrasound that complements video imaging allows surface and subsurface visualization and computer-assisted diagnosis. Using focused ultrasound (US) to mark sites of pathology with exogenous fluorescent agents permits follow-up with another device to provide therapy. This is based on an US-mediated targeted drug delivery system with fluorescence imaging guidance. An additional device may then be utilized for treatment verification and monitoring, exploiting the minimally invasive nature of CE. While such a theranostic patient pathway for gastrointestinal treatment is presently incomplete, the description in this paper of previous research and work under way to realize further components for the proposed pathway suggests it is feasible and provides a framework around which to structure further work.

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Section: Capsule Endoscopymentioning

confidence: 99%

Acoustic Sensing and Ultrasonic Drug Delivery in Multimodal Theranostic Capsule Endoscopy

Stewart

Qiu

Lay

et al. 2017

Sensors

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“…The VECTOR Project (supported by the European Union) revealed that the peak power required will be at least few hundred mW after taking into consideration all the on board power-consuming modules within a RCE [30,31]. Moreover, some advanced features including microsurgery, drug delivery and biopsy are also anticipated for multifunctional medical robot (MMR) WCE [32,33] that will also increase the power demands of the new generation of WCE systems. Accordingly, it can be concluded that the peak power requirement for the new generation of WCE is becoming much higher than that of the existing WCE units and the battery capacity may not be sufficient [30,34,35].…”

Section: Introductionmentioning

confidence: 99%

Application of Wireless Power Transmission Systems in Wireless Capsule Endoscopy: An Overview

Basar

Ahmad

Cho

et al. 2014

Sensors

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Wireless capsule endoscopy (WCE) is a promising technology for direct diagnosis of the entire small bowel to detect lethal diseases, including cancer and obscure gastrointestinal bleeding (OGIB). To improve the quality of diagnosis, some vital specifications of WCE such as image resolution, frame rate and working time need to be improved. Additionally, future multi-functioning robotic capsule endoscopy (RCE) units may utilize advanced features such as active system control over capsule motion, drug delivery systems, semi-surgical tools and biopsy. However, the inclusion of the above advanced features demands additional power that make conventional power source methods impractical. In this regards, wireless power transmission (WPT) system has received attention among researchers to overcome this problem. Systematic reviews on techniques of using WPT for WCE are limited, especially when involving the recent technological advancements. This paper aims to fill that gap by providing a systematic review with emphasis on the aspects related to the amount of transmitted power, the power transmission efficiency, the system stability and patient safety. It is noted that, thus far the development of WPT system for this WCE application is still in initial stage and there is room for improvements, especially involving system efficiency, stability, and the patient safety aspects.

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“…[188][189][190] Various commercial prototypes of capsule endoscope such as IntelliCap, [191,192] InteliSite, [193] Pulsincap, [194] and Enterion capsule, [195] have been designed and fabricated to achieve triggered drug release via different mechanisms. [188][189][190] Various commercial prototypes of capsule endoscope such as IntelliCap, [191,192] InteliSite, [193] Pulsincap, [194] and Enterion capsule, [195] have been designed and fabricated to achieve triggered drug release via different mechanisms.…”

Section: Wireless Endoscopic Capsulesmentioning

confidence: 99%

Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

Zhang

Jackson

Chiao

2017

Adv Funct Materials

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Microfabrication technology has enabled the development of novel controlled-release devices that possess an integration of structural, mechanical, and perhaps electronic features, which may address challenges associated with conventional delivery systems. In this feature article, microfabricated devices are described in terms of materials, mechanical design, working principles, and fabrication methods, all of which are key features for production of multifunctional, highly effective drug delivery systems. In addition, the current status and future prospects of different types of microfabricated devices for controlled drug delivery are summarized and analyzed with an emphasis on various routes of administration including ocular, oral, transdermal, and implantable systems. It is likely that microfabrication technology will continue to offer new, alternative solutions to design advanced and sophisticated drug delivery devices that promise to significantly improve medical care.

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Therapeutic Capsule Endoscopy: Opportunities and Challenges

Cited by 10 publications

References 34 publications

Acoustic Sensing and Ultrasonic Drug Delivery in Multimodal Theranostic Capsule Endoscopy

Acoustic Sensing and Ultrasonic Drug Delivery in Multimodal Theranostic Capsule Endoscopy

Application of Wireless Power Transmission Systems in Wireless Capsule Endoscopy: An Overview

Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

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