Therapeutic Constituents and Actions of Rubus Species

Patel, Asmita V.; Rojas-Vera, Janne; Dacke, C. G.

doi:10.2174/0929867043365143

Cited by 135 publications

(107 citation statements)

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“…4,19,20) Despite the absence of experimental studies concerning the analgesic properties of R. rosaefolius, other plants of the Rubus genus have exhibited important antinociceptive effects in mice. 6,12) Table 1 shows that the hydroalcoholic extract and any fractions caused a pronounced effect when analysed against writhing model in mice.…”

Section: Resultsmentioning

confidence: 99%

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Phytochemical and Analgesic Activity of Extract, Fractions and a 19-Hydroxyursane-Type Triterpenoid Obtained from Rubus rosaefolius (Rosaceae)

Kanegusuku

Sbors

Bastos

et al. 2007

Biological & Pharmaceutical Bulletin

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Rosaceae consists of a large family of plants, represented by fruits such as plums, cherries, damson plums, quinces, strawberries, pears and peaches.1) The plants to the genus Rubus, have been traditionally used to treat different diseases, particularly diabetes.2-4) Chemical and pharmacological studies have shown that some species produce active principles that exert antigastropathic, antiinflammatory, antioxidant activity.5-7) Besides these activities, it has been reported that extracts of some species of this genus are potential antimicrobial and analgesic sources. [8][9][10] Phytochemical studies carried out with these plants indicate the presence of steroids, triterpene and ellagic acid derivatives. 8,9,11) Recently, we have shown that another species, R. imperialis, presents hypoglycaemic, cytotoxic and antinociceptive actions. 9,[11][12][13] The main isolated active compound, named niga-ichigoside F1, showed marked antinociception and its mechanism of action appears to be related to the dopaminergic, cholinergic, glutamatergic, and tachykininergic and oxinitrergic systems. 14)Rubus rosaefolius, popularly known as "amora-do-mato" or "amora-vermelha" in Brazil, is a shrub measuring between 4 and 5 m, and is well distributed in the South of Brazil. 1,15) The current study extends our previous work on the biological properties of the Rubus species, and describes its phytochemical analysis and in vivo antinociceptive activity against two pain models in mice (writhing and formalin tests) of the extract, fractions and a pure compound isolated from the aerial parts of R. rosaefolius. Phytochemical Analysis Air-dried material from R. rosaefolius (700 g) was cut into small pieces and macerated with methanol at room temperature for 7 d. After filtration, the solvent was removed by rotatory evaporation under reduced pressure, yielding the respective methanolic extract (ME). Parallel to this, a hydroalcoholic extract (HE) was prepared through maceration of 100 g of plant with an ethanol-water (50 : 50) mixture and stored for use in the pharmacological test. The methanolic extract (35 g), were then suspended in a MeOH : water mixture (9 : 1) and successively partitioned with n-hexane, dichlomethane, ethyl acetate and n-butanol, to provide the respective fractions. The hexane and dichloromethane fractions (7.4, 4.2 g) were chromatographed on silica gel column eluted with a hexane : acetone mixture with increasing polarity. Similar fractions, which showed a positive reaction with anisaldehyde sulfuric reagents, were combined and rechromatographed as in the The Rubus species has been used in folk medicine to treat several ailments, including infectious and dolorous diseases. In this work we evaluate the phytochemical and analgesic activity of hydroalcoholic extract (HE), some fractions (hexane, dichloromethane, ethyl acetate and butanolic), as well as a pure compound denoted as 28-methoxytormentic acid (1) obtained from aerial parts of R. rosaefolius. The compounds were isolated and identified by chromatographic and spect...

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Section: Resultsmentioning

confidence: 99%

“…[2][3][4] Chemical and pharmacological studies have shown that some species produce active principles that exert antigastropathic, antiinflammatory, antioxidant activity. [5][6][7] Besides these activities, it has been reported that extracts of some species of this genus are potential antimicrobial and analgesic sources.…”

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confidence: 99%

Phytochemical and Analgesic Activity of Extract, Fractions and a 19-Hydroxyursane-Type Triterpenoid Obtained from Rubus rosaefolius (Rosaceae)

Kanegusuku

Sbors

Bastos

et al. 2007

Biological & Pharmaceutical Bulletin

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“…Some are cultivated in numerous varieties as industrial plants for the quality of nutritious and tasty fruits (Patel et al 2004). One of the varieties of Rubus is fruticosus which was introduced to official register and has been used in traditional medicine for their many medicinal properties (Alice and Campbell 1999).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity of raspberry (Rubus fruticosus) leaves extract and its effect on oxidative stability of sunflower oil

2014

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Efficacy of R. fruticosus leaves extract in stabilizing sunflower oil during accelerated storage has been studied. Extracts of R. fruticosus were prepared in different solvents which methanolic extract yield with 15.43 % was higher than water and acetone ones (11.87 and 6.62 %, respectively). Methanolic extract was chosen to evaluate its thermal stability at 70°C in sunflower oil, due to the highest yield, antioxidant and antiradical potential and also high content of phenolic compounds campared to other solvents. So, different concentrations of methanolic extract (200, 400, 600, 800 and 1,000 ppm) were added to sunflower oil. BHA and BHT at 200 ppm served as standards besides the control. Peroxide value (PV) and thiobarbituric acid (TBA) were taken as parameters for evaluation of effectiveness of R. fruticosus leaves extract in stabilization of sunflower oil. Moreover, antioxidant activity index (AAI) of the extract at 120°C at rancimat were conducted. Results from different parameters were in agreement with each other, suggesting the highest efficiency of 1,000 ppm of the extract followed by BHT, BHA and other concentrations of the extract. Results reveal the R. fruticosus leaves extract to be a potent antioxidant for stabilization of sunflower oil.

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“…The rising number of publications in this domain demonstrated that metabolomics is not just a new "omics" but a valuable emerging tool to study phenotype and changes in phenotype caused by environmental infl uences, disease or changes in genotype (6,9,10,54,77).…”

Section: Introductionmentioning

confidence: 99%