Therapeutic contact lenses fabricated by hyaluronic acid and silver incorporated bovine serum albumin porous films for the treatment of alkali-burned corneal wound

Yin, Chuanjin; Qi, Xueju; Wu, Jing; Guo, Chenglin; Wu, Xiaochen

doi:10.1016/j.ijbiomac.2021.06.155

Cited by 18 publications

(6 citation statements)

References 35 publications

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“…The films promoted corneal wound healing, reduced corneal neovascularization and opacification during the healing period, and mitigated the inflammatory response (Figure 13D). [161] Overall, the experimental evidence suggests that albumin-based biomaterials hold promise as suitable materials for corneal tissue engineering.…”

Section: Albumin-based Biomaterials For Corneal Tissue Engineeringmentioning

confidence: 99%

The Design and Developments of Protein‐Polysaccharide Biomaterials for Corneal Tissue Engineering

Prasathkumar

Chenthamara

Lin

et al. 2023

Adv Materials Technologies

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Corneal blindness is explained by a large reduction in vision loss caused by acute and chronic corneal diseases and/or disorders. Due to the severe unavailability of donor corneas, immune rejection, and the side effects of keratoprosthesis (KPro), vision‐impaired patients are often unable to restore their vision. Corneal tissue engineering appears to be a promising method using natural polymers made from different layers of corneal cells such as epithelium, stroma, and endothelium or full tissue equivalents. Proteins and polysaccharides are able to mimic the chemical composition of the native extracellular matrix (ECM), which has been extensively studied for corneal tissue engineering. Additionally, protein‐based materials are highly favored in corneal regenerative therapy as they have the proper cell‐binding sites for cell adhesion, corneal innervation regeneration, and oxidative stress suppression, while polysaccharide‐based materials can also promote cell proliferation and adhesion as well as ocular permeability. Herein, a comprehensive review of various biomaterials based on natural proteins (fibrin, fibrinogen, silk fibroin, collagen, gelatin, and serum albumin) and polysaccharides (chitin, chitosan, hyaluronic acid, alginate, cellulose, and gellan gum) for corneal tissue engineering are provided. The protein‐polysaccharide biomaterials are mainly used in the form of hydrogels, films, scaffolds, sutures, eye drops, nanocarriers, and nanocapsules to treat ocular diseases that cause blindness, such as corneal wounds, corneal ulcers, Goldenhar syndrome, corneal endothelium and stroma defects, corneal neovascularization, etc. In this review, insight is provided into recent developments in the areas of biomaterial design, cross‐linking strategy, corneal cell selection, and frontiers that are expected to offer researchers support and creativity in the development of corneal regenerative medicine.

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Section: Albumin-based Biomaterials For Corneal Tissue Engineeringmentioning

confidence: 99%

The Design and Developments of Protein‐Polysaccharide Biomaterials for Corneal Tissue Engineering

Prasathkumar

Chenthamara

Lin

et al. 2023

Adv Materials Technologies

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“…covalently bonded HA with bovine serum albumin/silver (BSA/Ag) porous films via chemical crosslinking and evaluated the therapeutic potential of this complex in an alkali burn-induced corneal injury mouse model. Results proved that the BSA/Ag/HA films had high potential in fabricating contact lenses, exhibiting the capacity to relieve inflammation and improve the rate of corneal healing (Yin et al., 2021 ). Since electric stimulation for corneal wound healing could imitate the natural wound-healing mechanism of the endogenous electric field to facilitate epithelial repair.…”

Section: Novel Contact Lenses In Ophthalmic Diseasesmentioning

confidence: 99%

Therapeutic applications of contact lens-based drug delivery systems in ophthalmic diseases

Zhao

Song

et al. 2023

Drug Delivery

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Traditional ophthalmic drugs, such as eye drops, gels and ointments, are accompanied by many problems, including low bioavailability and potential drug side effects. Innovative ophthalmic drug delivery systems have been proposed to overcome the limitations associated with traditional formulations. Recently, contact lens-based drug delivery systems have gained popularity owing to their advantages of sustained drug delivery, prolonged drug retention, improved bioavailability, and few drug side effects. Various methods have been successfully applied to drug-loaded contact lenses and prolonged the drug release time, such as chemical crosslinking, material embedding, molecular imprinting, colloidal nanoparticles, vitamin E modification, drug polymer film/coating, ion ligand polymerization systems, and supercritical fluid technology. Contact lens-based drug delivery systems play an important role in the treatment of multifarious ophthalmic diseases. This review discusses the latest developments in drug-loaded contact lenses for the treatment of ophthalmic diseases, including preparation methods, application in ophthalmic diseases and future prospects.

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“…13 HA-based wound dressings have been developed for many respects with good surface hydrophilicity. 14 HA polymer networks can be quickly formed by cross-linking through ion exchange processes. 15 Silk fibroin (SF) 16 is the fibrous protein extracted from silk produced by Bombyx mori .…”

Section: Introductionmentioning

confidence: 99%

“…Hyaluronic acid (HA), a biodegradable skin extracellular matrix (ECM) compound, is considered as a major player in the tissue regeneration process . HA-based wound dressings have been developed for many respects with good surface hydrophilicity . HA polymer networks can be quickly formed by cross-linking through ion exchange processes .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Antimicrobial Peptide Grafted HA/SF/Alg Wound Dressing Containing AIEgens for Infected Wound Treating

Lin,

Tan,

Deng

et al. 2024

ACS Omega

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Chronic wounds are characterized with excessive biofluid and persistent infection. Therefore, there is an urgent desire to develop a multifunctional wound dressing that can meet the extreme requirements including effective antibacterial and powerful wound microenvironment regulation and protection function to promote wounds heal quickly. In this study, a multifunctional composite dressing (HA-AMP/SF/Alg/Rb-BG-AIEgens) was synthesized by combining a mesoporous bioactive glass framework loaded with AIEgens (Rb-BG-AIEgens) with cross-linked antimicrobial peptide grafted hyaluronic acid (HA-AMP), sodium alginate (Alg), and silk fibroin (SF). It is important to note that the Rb-BG-AIEgens can achieve real-time and sensitive bacterial detection. HA-AMP can achieve broad spectrum antibacterial and avoid the residue of drug-resistant bacteria. The HA-AMP/SF/Alg/Rb-BG-AIEgens dressing can up-regulate related proliferative proteins, thereby promoting regeneration of tissue and the rapid healing of chronic wounds. With good biocompatibility and antibacterial ability, HA-AMP/SF/Alg/Rb-BG-AIEgens dressing has great potential to become a next generation wound dressing for clinical biological fluid management and chronic bacterial infection treatment.

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Therapeutic contact lenses fabricated by hyaluronic acid and silver incorporated bovine serum albumin porous films for the treatment of alkali-burned corneal wound

Cited by 18 publications

References 35 publications

The Design and Developments of Protein‐Polysaccharide Biomaterials for Corneal Tissue Engineering

The Design and Developments of Protein‐Polysaccharide Biomaterials for Corneal Tissue Engineering

Therapeutic applications of contact lens-based drug delivery systems in ophthalmic diseases

Antibacterial Antimicrobial Peptide Grafted HA/SF/Alg Wound Dressing Containing AIEgens for Infected Wound Treating

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