Therapeutic Cytapheresis

McLeod, Bruce C.

doi:10.1016/b978-0-443-06981-9.50061-2

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2010

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“…In patients with severe or resistant disease and high levels of parasitemia, some forms of exchange transfusion have been used as a means to remove both the infectious agent and potentially obstructive RBCs (13). Exchange transfusion as an adjunctive treatment for the most severe cases was introduced in 1974 (14).…”

Section: Discussionmentioning

confidence: 99%

Two Case Reports of Successful Therapeutic Erythrocytapheresis as an Adjunctive Therapy in Severe Falciparum Malaria

Chung¹,

Peck

Kim³

2010

Ther Apher Dial

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For many years, erythrocytapheresis has been used for the rapid removal of parasites in patients with severe and complicated malaria. Here, we report two cases of severe Plasmodium falciparum infection treated by erythrocytapheresis in addition to antimalarial chemotherapy. Both patients were referred to the emergency department with high fevers (40 degrees C) after returning from Africa. Peripheral blood smears showed 25.8% and 15% of parasitized erythrocytes, respectively. In both cases, antimalarial chemotherapy was begun and erythrocytapheresis was performed, and dramatic reduction of parasitemia was achieved. Clinical symptoms and laboratory abnormalities were also improved. Erythrocytapheresis in combination with antimalarial chemotherapy would be an effective and rapid approach to treat severe falciparum malaria.

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Section: Discussionmentioning

confidence: 99%