Therapeutic delivery with <scp>V‐amylose</scp>

Prasher, Parteek; Fatima, Rabab; Sharma, Mousmee

doi:10.1002/ddr.21804

Cited by 17 publications

(5 citation statements)

References 12 publications

(11 reference statements)

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“…The polysaccharides do not convert into acids at low temperatures, while in an alkaline solution, both the starch and cellulose thermochemically degrade to water-soluble compounds [64,65]. These properties support the colon-targeted release of the cargo drug molecules and prevent their premature release in the acidic pH of the stomach [66].…”

Section: Physicochemical Factorsmentioning

confidence: 94%

Current-status and applications of polysaccharides in drug delivery systems

Prasher

Sharma

Mehta

et al. 2021

Colloid and Interface Science Communications

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The polysaccharide-based advanced drug delivery system owing to their biocompatibility, ability to encapsulate the drug molecules in their interspaces, and ability to achieve a controlled release of the cargo drug molecules result in improved drug pharmacokinetics. The drug-loaded polysaccharides possess ability to evade the multidrug-resistant microbial efflux pumps by aggregation effect, whereas the drug loaded polysaccharidefabricated metal nanoparticles present an exceptional candidature for effectively transporting the drug molecules across the membrane barriers while enabling the theranostic applications at the same time. The biodegradability of polysaccharide based drug delivery systems ensure a sustained release of the encapsulated drug molecules, which minimizes the side effects caused by a burst release of the cargo therapeutics. These drug delivery systems proved highly beneficial for the NSAIDs that otherwise manifest ulcerogenic effect in the gastrointestinal tract. The large surface area of polysaccharides further provide a higher drug-loading capacity, which maintains the optimal concentration of the cargo drug at the target sites. The emerging applications of biodegradable polysaccharides in the designing of multicompartmental microspheres revolutionized tissue engineering, multi drug delivery, and cell culturing technologies. The present review deals with the current-status of polysaccharides as advanced drug delivery systems.

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Section: Physicochemical Factorsmentioning

confidence: 94%

Current-status and applications of polysaccharides in drug delivery systems

Prasher

Sharma

Mehta

et al. 2021

Colloid and Interface Science Communications

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“…The dicarbamate system linked to the lysine residue lining the enzyme active site, via carbonyl "O" atoms thereby forming a lysine adduct, which further interacts with the neighboring cysteine residues causing the crosslinking of the phosphate-binding site. [95][96][97][98]…”

Section: Benzoxazolone Derivatives As Pyrophosphate Mimics For Galnac...mentioning

confidence: 99%

Synthesis and biological profile of benzoxazolone derivatives

Prasher

Mall

Sharma

2023

Archiv der Pharmazie

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The benzoxazolone nucleus is an ideal scaffold for drug design, owing to its discrete physicochemical profile, bioisosteric preference over pharmacokinetically weaker moieties, weakly acidic behavior, presence of both lipophilic and hydrophilic fragments on a single framework, and a wider choice of chemical modification on the benzene and oxazolone rings. These properties apparently influence the interactions of benzoxazolone‐based derivatives with their respective biological targets. Hence, the benzoxazolone ring is implicated in the synthesis and development of pharmaceuticals with a diverse biological profile ranging from anticancer, analgesics, insecticides, anti‐inflammatory, and neuroprotective agents. This has further led to the commercialization of several benzoxazolone‐based molecules and a few others under clinical trials. Nevertheless, the SAR exploration of benzoxazolone derivatives for the identification of potential “hits” followed by the screening of “leads” provides a plethora of opportunities for further exploration of the pharmacological profile of the benzoxazolone nucleus. In this review, we aim to present the biological profile of different derivatives based on the benzoxazolone framework.

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“…Amylose has recently garnered great attention due to its tightly packed helical structure, physiological benevolence, biocompatibility, hydrophobic interior and hydrophilic exterior suitable for delivering various NSAIDs (non steroidal anti inflammatory drugs) and anti cancer drug molecules. [18] Amylose has low solubility in water and is easily retrogradable due to the presence of multiple hydrogen bonds between its hydroxyl groups that hampers its movement in aqueous solution. To overcome these obstacles, chemical modification is the most effective way to improve its structural and functional properties.…”

Section: Starchmentioning

confidence: 99%

Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

et al. 2023

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The pressing need for the development of diversified and non‐toxic biomaterials in recent decades has led to the emergence of novel and valuable structural modifications in polysaccharides to broaden their spectrum of applications. Polysaccharides are macromolecules with multifaceted diverse structures and exhibit wide range of pharmacological and biological activities. Naturally occurring polysaccharides such as starch, chitosan, alginate, acetalated dextran and pectin could potentially negate major concerns associated with the selection of suitable polysaccharides without compromising their unique bioactive nature. Chemical modification of polysaccharides offers distinctive benefits such as improved biocompatibility, stability, solubility, and functionality making them more valuable for a variety of biomedical applications such as drug delivery, gene delivery, cell culture technology and tissue engineering. The present review is a compendium of relevant chemically modified polysaccharides and discusses their role in diverse fields of pharmacy and medicine.

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Therapeutic delivery with V‐amylose

Cited by 17 publications

References 12 publications

Current-status and applications of polysaccharides in drug delivery systems

Current-status and applications of polysaccharides in drug delivery systems

Synthesis and biological profile of benzoxazolone derivatives

Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

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