Therapeutic drug monitoring of disease-modifying antirheumatic drugs in circulating leukocytes in immune-mediated inflammatory diseases

Cheng, Dao-Hai; Huang, Zhenguang

doi:10.1007/s10787-023-01243-8

Inflammopharmacol

2023

DOI: 10.1007/s10787-023-01243-8

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Therapeutic drug monitoring of disease-modifying antirheumatic drugs in circulating leukocytes in immune-mediated inflammatory diseases

Dao-Hai Cheng

Zhenguang Huang

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2024

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Ulcerative colitis: molecular insights and intervention therapy

Liang,

Li,

Lee

et al. 2024

Mol Biomed

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Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by abdominal pain, diarrhea, rectal bleeding, and weight loss. The pathogenesis and treatment of UC remain key areas of research interest. Various factors, including genetic predisposition, immune dysregulation, and alterations in the gut microbiota, are believed to contribute to the pathogenesis of UC. Current treatments for UC include 5-aminosalicylic acids, corticosteroids, immunosuppressants, and biologics. However, study reported that the one-year clinical remission rate is only around 40%. It is necessary to prompt the exploration of new treatment modalities. Biologic therapies, such as anti-TNF-α monoclonal antibody and JAK inhibitor, primarily consist of small molecules targeting specific pathways, effectively inducing and maintaining remission. Given the significant role of the gut microbiota, research into intestinal microecologics, such as probiotics and prebiotics, and fecal microbiota transplantation (FMT) shows promising potential in UC treatment. Additionally, medicinal herbs, such as chili pepper and turmeric, used in complementary therapy have shown promising results in UC management. This article reviews recent findings on the mechanisms of UC, including genetic susceptibility, immune cell dynamics and cytokine regulation, and gut microbiota alterations. It also discusses current applications of biologic therapy, herbal therapy, microecologics, and FMT, along with their prospects and challenges.

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Ulcerative colitis: molecular insights and intervention therapy

Liang,

Li,

Lee

et al. 2024

Mol Biomed

View full text Add to dashboard Cite

show abstract

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Therapeutic drug monitoring of disease-modifying antirheumatic drugs in circulating leukocytes in immune-mediated inflammatory diseases

Cited by 1 publication

References 86 publications

Ulcerative colitis: molecular insights and intervention therapy

Ulcerative colitis: molecular insights and intervention therapy

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