Therapeutic drug monitoring of two co-administered drugs through development of two ecological chromatographic methods: Invivo application

Abdelwahab, Nada S.; Edrees, Fadwa H.; alsaadi, Mohamed T.; Amin, Noha H.; Saad, Ahmed S.

doi:10.1016/j.microc.2020.104935

Cited by 7 publications

(3 citation statements)

References 38 publications

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“…As a result, therapeutic drug monitoring (TDM) is frequently necessary to decrease toxicity, boost clinical efficacy, and prevent the development of antimicrobial resistance. For the greatest conceivable patient benefit, this monitoring tries to maintain medication levels in plasma or blood within a specific therapeutic range (35,36).…”

Section: Molecular Formula: C16h14f3n3o2smentioning

confidence: 99%

Mini Review on Different Analytical Approaches Applied on some Selected GIT acting Combination

Darweish

Fayez

Marzouk

et al. 2023

ERU Research Journal

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In order to encourage and facilitate collecting literature review for other researchers who will have studies related to the presented compounds, the following article was introduced by presenting a mini-review of the different methods applied for quantitative determination of some drugs affecting GIT namely, Lansoprazole (LAN) co-formulated with Clarithromycin (CLR) and Tinidazole (TD), and Phloroglucinol (PHG) and Trimethylphloroglycinol (TMG) combination, in their drug mixture forms using different analytical techniques. Helicobacter pylori (H. Pylori) is a fairly prevalent infection that disrupts the stomach, causing several annoyances signs such as chronic gastritis, peptic ulcers, and gastric cancer. Lately, it has been shown that COVID-19 patients' gastrointestinal symptoms are negatively impacted by H. Pylori infection. An effective triple therapy regimen, which typically includes antibiotics and stomach protection, is required to eradicate this bacterial infection. This study discussed the pharmacopeia methods applied for the studied drugs in addition to different techniques which were used for simultaneous determination of the presented compounds in their mixture formulations; including spectrophotometric (UV and visible), electrochemical, in addition to chromatographic (TLC and HPLC) methods either in a biological fluid or in their pharmaceutical dosage forms. All the discussed approaches in this review were applied and ERURJ 2023, 2, 2, 222 -236 223 validated following the ICH guidelines. Some of these methods were accomplished according to the green chemistry and evaluated with the green assessment approaches.

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Section: Molecular Formula: C16h14f3n3o2smentioning

confidence: 99%

Mini Review on Different Analytical Approaches Applied on some Selected GIT acting Combination

Darweish

Fayez

Marzouk

et al. 2023

ERU Research Journal

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“…Analysts aim to reduce or avoid the consumption and emission of hazardous substances throughout the analytical procedure. 40,41 Different green chemistry metrics have been developed for the evaluation of greenness standards in such procedures. The National Environmental Method Index (NEMI) is among the oldest techniques built to provide a clear representation of the greenness of the analytical method.…”

Section: Introductionmentioning

confidence: 99%

Experimentally designed chromatographic method for the simultaneous analysis of dimenhydrinate, cinnarizine and their toxic impurities

et al. 2021

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“…The TLCdensitometry is considered a sensitive, accurate, and reliable analytical tool that is cost and time effective. 46,47 Additionally, no method was reported for the simultaneous determination of DMH, CIN, and their impurities (BZP and DPP). Hence, the current work was also aimed to develop a TLC-densitometric for simultaneous determination of DMH, CIN, and their toxic impurities.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous estimation of dimenhydrinate, cinnarizine and their toxic impurities benzophenone and diphenylmethylpiperazine; in silico toxicity profiling of impurities

et al. 2020

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Therapeutic drug monitoring of two co-administered drugs through development of two ecological chromatographic methods: Invivo application

Cited by 7 publications

References 38 publications

Mini Review on Different Analytical Approaches Applied on some Selected GIT acting Combination

Mini Review on Different Analytical Approaches Applied on some Selected GIT acting Combination

Experimentally designed chromatographic method for the simultaneous analysis of dimenhydrinate, cinnarizine and their toxic impurities

Simultaneous estimation of dimenhydrinate, cinnarizine and their toxic impurities benzophenone and diphenylmethylpiperazine; in silico toxicity profiling of impurities

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