Therapeutic effect of acupuncture on the outcomes of in vitro fertilization: a systematic review and meta-analysis

Qian, Yi; Xia, Xinru; Ochin, Humphrey; Huang, Cun; Gao, Chao; Gao, Li; Cui, Yugui; Liu, Jiayin; Meng, Yan

doi:10.1007/s00404-016-4255-y

Cited by 50 publications

(53 citation statements)

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“…[19][20][21] This was in accordance with previous research that suggested that the success of IVF programs was greater with acupuncture therapy, which had begun since the COS stage than only around embryotransfer time. 21 It was proven in this current study that complementary acupuncture therapy performed before and during COS could increase oocyte maturation significantly. Fertilization rates in the verum-EA group were significantly higher than in the sham-EA group (P = 0.03); see…”

Section: Effect Of Acupuncture In Ivf Program 291supporting

confidence: 87%

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Electroacupuncture Enhances Number of Mature Oocytes and Fertility Rates forIn VitroFertilization

Kusuma

Oktari

Mihardja

et al. 2019

Medical Acupuncture

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Objective: The increasing prevalence of infertility every year is in line with the increasing need for in vitro fertilization (IVF) programs. Failure of oocyte maturation is an obstacle that often causes low success in IVF. According to several studies, controlled ovarian stimulation (COS) has been reported to increase the risk of granulosa-cell apoptosis associated with inhibition of oocyte maturation. This study was conducted to determine the effect of electroacupuncture (EA) on oocyte maturation; rate of fertilization; granulosa-cell apoptosis; and levels of growth-differentiation factor 9 (GDF9) and bone-morphogenetic protein 15 (BMP15) an IVF program. Materials and Methods: A randomized controlled trial was conducted with 24 subjects who were in the IVF program. Subjects were randomly allocated into verum-EA (n = 12) and sham-EA groups (n = 12). Microscopic assessment of oocyte maturation and rate of fertilization was performed by embryologists, and examinations of granulosa-cell apoptosis index (Bax/Bcl-2 ratio), GDF9, and BMP15 were performed, using real-time quantitative polymerase chain reaction and messenger-RNA techniques. Results: There were significant differences in oocyte maturation (P = 0.02) and fertilization rates (P = 0.03) between the verum-EA and sham-EA groups. There were differences in granulosa-cell apoptosis index between the verum-EA and sham-EA groups (P < 0.001). There were significant differences in Bax-protein expression (P = 0.04) and Bcl-2 (P = 0.03) granulosa cells between the verum-EA and sham-EA groups. There was no significant difference in GDF9 levels (P = 0.34) and BMP15 (p = 0.47) between the verum-EA and sham-EA groups. Conclusions: EA can enhance oocyte maturation and fertilization rate, and reduce the granulosa-cell apoptosis index in an IVF program.

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Section: Effect Of Acupuncture In Ivf Program 291supporting

confidence: 87%

“…These results are parallel with previous studies by Cui et al 19 and Li et al, 20 who examined the effect of EA on the oocyte quality of patients with polycystic ovary syndrome (PCOS) undergoing IVF, and a study by Chen et al in patients with poor ovarian response (POR) who also underwent IVF. 21 All three studies showed improvements…”

Section: Discussionmentioning

confidence: 89%

Electroacupuncture Enhances Number of Mature Oocytes and Fertility Rates forIn VitroFertilization

Kusuma

Oktari

Mihardja

et al. 2019

Medical Acupuncture

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“…Nowadays, numerous systematic reviews have investigated the effects of AA on insomnia [18], postoperative pain [19], and in vitro fertilization [20]. Nevertheless, there was no systematic review specifically focusing on the efficacy of AA for preventing constipation in leukemia patients undergoing chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Non-Invasive Auricular Acupressure for Treating Constipation in Leukemia Patients Undergoing Chemotherapy: A Systematic Review

Chen

Lin²,

Wang

2018

Complement Med Res

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Background: The aim of this systematic review was to evaluate the available evidence from randomized controlled trials (RCTs) of auricular acupressure (AA) therapy for preventing constipation in leukemia patients undergoing chemotherapy. Methods: We searched 5 English databases and 4 Chinese databases, from their inception until August 2017. Quantitative syntheses of RCTs were conducted using RevMan 5.3 software. Study selection, data extraction, and validation were performed independently by 2 reviewers. Cochrane criteria for risk-of-bias were used to assess the methodological quality of the trials. Results: Five RCTs met the inclusion criteria, and most were of low methodological quality. All RCTs compared AA + routine care with routine care alone. Our analysis found that complementary effects of AA can improve the scores of the Bristol Stool Form (BSF), the Constipation Assessment Scale (CAS), and the Patient Assessment of Constipation-Quality of Life (PAC-QOL). However, the same positive results were not found in terms of the Fatigue Severity Scale (FSS), the EuroQoL 5-domain (EQ-5D), and the Hospital Anxiety Depression Scale (HADS). Conclusions: Overall, as a potential safety therapy, AA may be recommended in addition to routine care including use of laxatives to prevent constipation in leukemia patients undergoing chemotherapy. In the future, more rigorous RCTs must be conducted to overcome the limitations of our existing data and to confirm the effect and safety of AA for managing constipation in leukemia patients undergoing chemotherapy.

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“…Often, infertile women resort to various complementary/supportive practices to cope with stress. Studies have revealed that of these practices, acupuncture increased self‐efficacy; art therapies reduced hopelessness, anxiety, and depressive symptoms; and relaxation techniques affected stress reduction . In addition to these practices, yoga, another complementary/supportive practice, has demonstrated effectiveness in reducing intense stress, depression, and anxiety and in increasing the quality of life of the individual .…”

Section: Introductionmentioning

confidence: 99%

The effect of yoga on stress level in infertile women

Kırca

Pasinlioğlu

2019

Perspect Psychiatr Care

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Purpose The aim of the present study was to examine the effects of planned yoga practices on stress levels in infertile women. Design and Methods This randomized controlled study included 128 volunteer women who were registered at a private in vitro fertilization (IVF) clinic and received infertility treatment. The patients in the experimental group took part in the yoga program twice a week for 6 weeks. A personal information form and The Copenhagen Multi‐center Psychosocial Infertility (COMPI) Fertility Problem Stress Scale were used to collect data. Findings The differences between the mean scores of the control and experimental groups on the COMPI Fertility Problem Stress Scale at pre‐ and posttests were statistically significant (P < 0.05). Practice Implications Because yoga practices may be effective in reducing stress in infertile women, these applications can be performed before treatment. It may reduce patients’ stress and increase the success of the treatment. These findings indicate that yoga could reduce stress levels in infertile women.

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Therapeutic effect of acupuncture on the outcomes of in vitro fertilization: a systematic review and meta-analysis

Cited by 50 publications

References 50 publications

Electroacupuncture Enhances Number of Mature Oocytes and Fertility Rates forIn VitroFertilization

Electroacupuncture Enhances Number of Mature Oocytes and Fertility Rates forIn VitroFertilization

Efficacy of Non-Invasive Auricular Acupressure for Treating Constipation in Leukemia Patients Undergoing Chemotherapy: A Systematic Review

The effect of yoga on stress level in infertile women

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