Therapeutic effect of Chinese prescription Kangen-karyu in patients with diabetic nephropathy

Abstract

diabetic nephropathy, traditional Chinese medicine, Kangen-karyu, case report Diabetic nephropathy is the kidney disease that occurs as a result of diabetes. A number of new therapies have been developed based on the pathogenic factors of diabetic nephropathy such as intensive glycemic control, precise hypertension control, lifestyle modifications including exercise and an energy-restricted diet, and numerous novel agents. The utilization of traditional Chinese medicine for patients with diabetic nephropathy has also received increasing attention due to its wide availability, weak side-effects, and proven therapeutic mechanisms and benefits. In this paper, we report the case of patients with diabetic nephropathy, stage 2 or 3. Kangen-karyu extract (7.5 g/day) was administered three times per day for 6 months. The estimated glomerular filtration rate was increased at the 6-month follow-up. The serum creatinine level decreased following administration. At that time, somatic and subjective symptoms had partially disappeared. Here, we present evidence that Kangen-karyu exerts a renoprotective effect against the development of diabetic nephropathy.

A Network Pharmacology Approach to Understand the Action Mechanisms of the TangShenKangPing Decoction for Diabetic Nephropathy Treatment

“…Moreover, several studies have focused on the identification of bioactive compounds and molecular mechanisms of the renoprotective effects of TCM owing to its multi-target functions. [33,34] A TCM is typically a complex collection of different chemical components that work synergistically, as opposed to a single product with only one active chemical component. In addition, the efficacy of an individual active component of a herbal medication cannot be used to infer its overall effectiveness in treatment.…”

Dendrobium mixture attenuates renal damage in rats with diabetic nephropathy by inhibiting the PI3K/Akt/mTOR pathway

“…Recently, Traditional Chinese Medicine (TCM) has achieved good efficacy in the treatment of DN. Numerous TCMs have been used in clinical practice and have shown promising results in the treatment of diabetes and its complications (31,32). Unlike a single compound that has only one active chemical component, TCM is usually a complex combination of chemicals that work synergistically.…”