Therapeutic effect of cold atmospheric plasma and its combination with radiation as a novel approach on inhibiting cervical cancer cell growth (HeLa cells)

Kenari, Ali Jamaati; Siadati, S N; Abedian, Zeinab; Sohbatzadeh, Farshad; Amiri, Mehrangiz; Gorji, Kourosh Ebrahimnejad; Babapour, Hamed; Zabihi, Ebrahim; Ghoreishi, Seyedeh Masoumeh; Mehraeen, Rahele; Monfared, Ali Shabestani

doi:10.1016/j.bioorg.2021.104892

Cited by 14 publications

(8 citation statements)

References 31 publications

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“…[15][16][17] Since the use of PAL is a relatively new therapy, to date, most of the cytotoxicity studies have focused on PAL treatment alone. A handful of studies have reported on the effects of PAL or direct plasma treatment combined with radiation, [18][19][20][21][22][23] but examining the interactions for synergy or antagonism was not always the subject of the investigation. Hydrogen peroxide has been shown to have potential as a radiation sensitizer [17,[24][25][26][27][28] and is a major component of PAL.…”

mentioning

confidence: 99%

Plasma activated liquid synergistically enhances response to radiation for improved cancer therapy

Harley

Suchowerska

Rogers

et al. 2022

Plasma Processes & Polymers

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Plasma activated liquid (PAL) is an emerging cancer treatment. Two prostate cell lines and one melanoma cell line were used in clonogenic assays to assess the cytotoxicity of PAL and radiation individually and in combination, using the multiplicative survival method to quantify interactions between the treatments. PAL applied before a dose of radiation synergistically increases cytotoxicity in cancer cells, while in immortalized normal cells, the combined treatment was found to be antagonistic.These results demonstrate the potential to improve the therapeutic window of cancer treatment, giving a higher cancer response rate with less toxicity.

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mentioning

confidence: 99%

Plasma activated liquid synergistically enhances response to radiation for improved cancer therapy

Harley

Suchowerska

Rogers

et al. 2022

Plasma Processes & Polymers

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“…Detailed biochemical pathways through which CAP (potentially) work have been previously reviewed [ 29 , 68 ]. In vitro studies have been conducted on a wide range of gynaecological cell lines (see also Table 1 in the work of Zubor et al [ 68 ]) of cervical cancer [ 69 , 70 , 71 , 72 ], ovarian cancer [ 73 , 74 , 75 , 76 , 77 , 78 ], and colon cancer [ 79 , 80 , 81 ], see Table 3 . With an aim to increase differences in cell response between healthy and cancer cells, more intricate applications are in development, combining CAP with hyperthermia [ 82 ], radiotherapy [ 72 ], or photodynamic therapy using targeted polymeric nanoparticles [ 83 ].…”

Section: Resultsmentioning

confidence: 99%

Plasma Device Functions and Tissue Effects in the Female Pelvis—A Systematic Review

Berg

Boer

Gao

et al. 2023

Cancers

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Medical use of (non-)thermal plasmas is an emerging field in gynaecology. However, data on plasma energy dispersion remain limited. This systematic review presents an overview of plasma devices, fields of effective application, and impact of use factors and device settings on tissues in the female pelvis, including the uterus, ovaries, cervix, vagina, vulva, colon, omentum, mesenterium, and peritoneum. A search of the literature was performed on 4 January 2023 in the Medline Ovid, Embase, Cochrane, Web of Science, and Google Scholar databases. Devices were classified as plasma-assisted electrosurgery (ES) using electrothermal energy, neutral argon plasma (NAP) using kinetic particle energy, or cold atmospheric plasma (CAP) using non-thermal biochemical reactions. In total, 8958 articles were identified, of which 310 were scanned, and 14 were included due to containing quantitative data on depths or volumes of tissues reached. Plasma-assisted ES devices produce a thermal effects depth of <2.4 mm. In turn, NAP effects remained superficial, <1.0 mm. So far, the depth and uniformity of CAP effects are insufficiently understood. These data are crucial to achieve complete treatment, reduce recurrence, and limit damage to healthy tissues (e.g., prevent perforations or preserve parenchyma). Upcoming and potentially high-gain applications are discussed, and deficits in current evidence are identified.

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“…To achieve personalized treatment, CAP is emerging as a promising approach, as the parameters of the plasma device can be fine-tuned during the treatment to suit the patient's specific dosage. CAP has been shown to reprogram the tumor microenvironment [143][144][145], inhibit tumor growth with high selectivity, and even enhance the effectiveness of other treatment modalities like chemotherapy [146][147][148][149], immunotherapy [150,151], radiotherapy [152][153][154][155], and nanomedicine [156][157][158][159][160] with improved treatment outcomes and minimized sideeffects [161]. The self-adaptive nature of the adaptive plasma system complements the power of ML.…”

Section: Discussionmentioning

confidence: 99%

Personalized Plasma Medicine for Cancer: Transforming Treatment Strategies with Mathematical Modeling and Machine Learning Approaches

Ramaswamy,

Keidar

2023

Applied Sciences

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Plasma technology shows tremendous potential for revolutionizing oncology research and treatment. Reactive oxygen and nitrogen species and electromagnetic emissions generated through gas plasma jets have attracted significant attention due to their selective cytotoxicity towards cancer cells. To leverage the full potential of plasma medicine, researchers have explored the use of mathematical models and various subsets or approaches within machine learning, such as reinforcement learning and deep learning. This review emphasizes the significant application of advanced algorithms in the adaptive plasma system, paving the way for precision and dynamic cancer treatment. Realizing the full potential of machine learning techniques in plasma medicine requires research efforts, data sharing, and interdisciplinary collaborations. Unraveling the complex mechanisms, developing real-time diagnostics, and optimizing advanced models will be crucial to harnessing the true power of plasma technology in oncology. The integration of personalized and dynamic plasma therapies, alongside AI and diagnostic sensors, presents a transformative approach to cancer treatment with the potential to improve outcomes globally.

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Therapeutic effect of cold atmospheric plasma and its combination with radiation as a novel approach on inhibiting cervical cancer cell growth (HeLa cells)

Cited by 14 publications

References 31 publications

Plasma activated liquid synergistically enhances response to radiation for improved cancer therapy

Plasma activated liquid synergistically enhances response to radiation for improved cancer therapy

Plasma Device Functions and Tissue Effects in the Female Pelvis—A Systematic Review

Personalized Plasma Medicine for Cancer: Transforming Treatment Strategies with Mathematical Modeling and Machine Learning Approaches

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