2023
DOI: 10.3389/fnbeh.2022.1068736
|View full text |Cite
|
Sign up to set email alerts
|

Therapeutic effect of combination vitamin D3 and siponimod on remyelination and modulate microglia activation in cuprizone mouse model of multiple sclerosis

Abstract: Stimulation of remyelination is critical for the treatment of multiple sclerosis (MS) to alleviate symptoms and protect the myelin sheath from further damage. The current study aimed to investigate the possible therapeutic effects of combining vitamin D3 (Vit D3) and siponimod (Sipo) on enhancing remyelination and modulating microglia phenotypes in the cuprizone (CPZ) demyelination mouse model. The study was divided into two stages; demyelination (first 5 weeks) and remyelination (last 4 weeks). In the first 5… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
3
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(3 citation statements)
references
References 125 publications
0
3
0
Order By: Relevance
“…However, it is possible to hypothesize a synergistic effect for other DMTs as well. In a murine model, the combination of vitamin D and Siponimod modulated the expression levels of microglia phenotype genes at the early and late remyelination stages [74]. In pwMS treated with Ocrelizumab, vitamin D serum levels of < 30 ng/mL were associated with a higher likelihood of early B cell reappearance at the six-month follow-up [18].…”
Section: Discussionmentioning
confidence: 99%
“…However, it is possible to hypothesize a synergistic effect for other DMTs as well. In a murine model, the combination of vitamin D and Siponimod modulated the expression levels of microglia phenotype genes at the early and late remyelination stages [74]. In pwMS treated with Ocrelizumab, vitamin D serum levels of < 30 ng/mL were associated with a higher likelihood of early B cell reappearance at the six-month follow-up [18].…”
Section: Discussionmentioning
confidence: 99%
“…In the late 1960s, cuprizone-induced demyelination was first seen in Swiss mice [3]. Cuprizone is a copper chelator that produces demyelination in the mouse central nervous system (CNS), mainly in the corpus callosum (CC), by triggering oligodendrocyte death and activation of microglia and astrocytes inside demyelinating lesions [4]. Demyelination appears three weeks after the commencement of the cuprizone administration.…”
Section: Introductionmentioning
confidence: 99%
“…Scientists have, therefore, focused a lot of research on developing safe and effective neuroprotective medicines [1,6]. Adaptogens are plant-based medical and nutritional supplements that improve living organisms' adaptation, resilience, and survival without harming the body's homeostasis [4]. In this regard, seaweed may be a source of neuroprotective adaptogens [1].…”
Section: Introductionmentioning
confidence: 99%