Therapeutic effect of CpG-enriched plasmid administration on the tight-skin mouse model of scleroderma

Shen, Yan; Ichino, Motohide; Nakazawa, Makoto; Ikejima, Takashi; Kojima, Yoshitsugu; Okuda, Kenji; Minami, Manabu

doi:10.1016/j.jaut.2005.01.014

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2015

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“…Furthermore, the topical administration of an interferon-gene therapy decreased collagen synthesis and upregulated the production of Th1 cytokines [70]. The use of synthetic oligodeoxynucleotides (ODN) containing immunomodulatory CpG motifs in these models has also been shown to block Th2-mediated responses, thus improving skin fibrosis but not emphysema [71,72]. Treatment of Tsk/+ mice with rapamycin, an immunosuppressive molecule that inhibits the mTOR pathway, decreased the production of profibrotic cytokines such as IL-4, IL-6, IL-17 and TGF-and auto-antibodies [73].…”

Section: F Batteuxmentioning

confidence: 99%

Animal Models of Systemic Sclerosis

Morin¹,

Kavian²,

Batteux³

2015

CPD

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Systemic sclerosis is a systemic connective tissue disorder characterized by the fibrosis of the skin and certain visceral organs, vasculopathy, and immunological abnormalities. Several genetic and inducible animal models of SSc have been developed and are available for research studies. The purpose of this review is to summarize the various animal models of systemic sclerosis and describe the various contributions of these models in terms of understanding the pathophysiology of the condition and searching for new therapeutic strategies for this incurable disease.

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