Therapeutic effect of decellularized extracellular matrix-based hydrogel for radiation esophagitis by 3D printed esophageal stent

Ha, Dong Heon; Chae, Suhun; Lee, Jae Yeon; Kim, Jae Yun; Yoon, Jungbin; Sen, Tugce; Lee, Sung Woo; Kim, Hak Jae; Cho, Jaeho; Cho, Dong‐Woo

doi:10.1016/j.biomaterials.2020.120477

Cited by 60 publications

(33 citation statements)

References 69 publications

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“…As characteristic of biological muscle tissues, such constructs could also respond to incoming electric stimuli with whole-tissue mechanical contraction, indicating efficient bioelectrical communication. Alternatively, numerous other works have disclosed the superior organotypic biofunctionality that arises from incorporating tissue-specific dECMs within the development of cell-laden materials, which have yielded functional microtissue analogues across a broad range of human tissues: such as (i) cornea, (ii) oesophagus, (iii) peripheral nerves, (iv) blood vessels, (v) heart, (vi) cartilage, (vii) adipose tissue, (viii) liver, (ix) lung, (x) pancreas, and (xi) kidneys [51,54,55]. In addition, aided by recent advances in tools dedicated to omics analysis, researchers are progressively identifying key components present in such organotypic dECMs that are the major drivers of organogenesis and/or responsible for augmenting the constructs bioperformance beyond those of naïve cell assemblies [50].…”

Section: Programming Living Materials Behaviourmentioning

confidence: 99%

Engineering mammalian living materials towards clinically relevant therapeutics

2021

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Section: Programming Living Materials Behaviourmentioning

confidence: 99%

Engineering mammalian living materials towards clinically relevant therapeutics

2021

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“…Engineering of an esophageal stent using esophageal-specific bioink to provide tissue-specific microenvironments for therapeutic effects [87] STL-based 3D printing Bioresorbable and drug-eluting vascular stent [209] Figure 7. Representative examples of 3D printed transdermal/surgical drug delivery systems.…”

Section: Surgical Stentmentioning

confidence: 99%

“…However, a mechanically driven approach can precisely regulate the amount of extruded material when compared with the pneumatic system, causing a delay time due to the compressed air volume. Unlike inkjet-based 3D printing that requires low-viscosity bioink, both extrusion mechanisms can employ a wide range of high-viscosity bioinks (0.03–6 10 4 Pa∙s), including dECM, gelatin, alginate solution, and thermally or chemically molten synthetic polymers [ 85 , 86 , 87 , 88 ]. Undoubtedly, the use of bioink that has high mechanical strength affords the possibility of fabricating a final tissue architecture with more robust mechanical properties.…”

Section: Advent Of 3d Printing For Pharmaceutical Applicationmentioning

confidence: 99%

“…As successive invasive surgery is considered a significant burden to patients, the current study of 3D printed stents mainly focused on the use of biomaterials that can safely disintegrate within the body. Ha et al developed a PCL-based esophageal biodegradable stent loaded with an esophagus-derived ECM hydrogel for therapeutic purposes [ 87 ]. The authors demonstrated the physical stability of the polymeric stent and the therapeutic effect of the hydrogel without any cytotoxic or adverse outcomes during degradation of the PCL substructure in an esophagitis animal model.…”

Section: Drug Delivery Systemmentioning

confidence: 99%

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3D Printing of Pharmaceutical Application: Drug Screening and Drug Delivery

et al. 2021

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Advances in three-dimensional (3D) printing techniques and the development of tailored biomaterials have facilitated the precise fabrication of biological components and complex 3D geometrics over the past few decades. Moreover, the notable growth of 3D printing has facilitated pharmaceutical applications, enabling the development of customized drug screening and drug delivery systems for individual patients, breaking away from conventional approaches that primarily rely on transgenic animal experiments and mass production. This review provides an extensive overview of 3D printing research applied to drug screening and drug delivery systems that represent pharmaceutical applications. We classify several elements required by each application for advanced pharmaceutical techniques and briefly describe state-of-the-art 3D printing technology consisting of cells, bioinks, and printing strategies that satisfy requirements. Furthermore, we discuss the limitations of traditional approaches by providing concrete examples of drug screening (organoid, organ-on-a-chip, and tissue/organ equivalent) and drug delivery systems (oral/vaginal/rectal and transdermal/surgical drug delivery), followed by the introduction of recent pharmaceutical investigations using 3D printing-based strategies to overcome these challenges.

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“…This method has a relatively stable operation process and can produce uniform and continuous micron or nanofibers [ 33 , 34 ]. Currently, compared to electrospinning, many other stent preparation methods are relatively complicated to produce a suitable structure [ 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Coaxial Electrospun PLLA Fibers Modified with Water-Soluble Materials for Oligodendrocyte Myelination

et al. 2021

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Myelin sheaths are essential in maintaining the integrity of axons. Development of the platform for in vitro myelination would be especially useful for demyelinating disease modeling and drug screening. In this study, a fiber scaffold with a core–shell structure was prepared in one step by the coaxial electrospinning method. A high-molecular-weight polymer poly-L-lactic acid (PLLA) was used as the core, while the shell was a natural polymer material such as hyaluronic acid (HA), sodium alginate (SA), or chitosan (CS). The morphology, differential scanning calorimetry (DSC), Fourier transform infrared spectra (FTIR), contact angle, viability assay, and in vitro myelination by oligodendrocytes were characterized. The results showed that such fibers are bead-free and continuous, with an average size from 294 ± 53 to 390 ± 54 nm. The DSC and FTIR curves indicated no changes in the phase state of coaxial brackets. Hyaluronic acid/PLLA coaxial fibers had the minimum contact angle (53.1° ± 0.24°). Myelin sheaths were wrapped around a coaxial electrospun scaffold modified with water-soluble materials after a 14-day incubation. All results suggest that such a scaffold prepared by coaxial electrospinning potentially provides a novel platform for oligodendrocyte myelination.

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Therapeutic effect of decellularized extracellular matrix-based hydrogel for radiation esophagitis by 3D printed esophageal stent

Cited by 60 publications

References 69 publications

Engineering mammalian living materials towards clinically relevant therapeutics

Engineering mammalian living materials towards clinically relevant therapeutics

3D Printing of Pharmaceutical Application: Drug Screening and Drug Delivery

Coaxial Electrospun PLLA Fibers Modified with Water-Soluble Materials for Oligodendrocyte Myelination

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