Therapeutic Effect of Epidurally Administered Lipo-Prostaglandin E1 Agonist in a Rat Spinal Stenosis Model

Park, Sang Hyun; Lee, Pyung Bok; Choe, Gyu-Ha; Moon, Jee Yeon; Nahm, Francis Sahngun; Kim, Yong Chul

doi:10.3344/kjp.2014.27.3.219

Cited by 12 publications

(11 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We believe that the pathophysiology of spinal stenosis is multifactorial [26]. Although mechanical compression of the spinal canal is a major factor, subjective discomfort, inflammatory effects [27–29], and depression may also contribute to the disease's pain intensity [30]. …”

Section: Discussionmentioning

confidence: 99%

Optimal Cut-Off Value of the Superior Articular Process Area as a Morphological Parameter to Predict Lumbar Foraminal Stenosis

Lim

Choi

Cho

et al. 2017

Pain Research and Management

View full text Add to dashboard Cite

Background. We devised a new morphological parameter called the superior articular process area (SAPA) to evaluate the connection between lumbar foraminal stenosis (LFS) and the superior articular process. Objective. We hypothesized that the SAPA is an important morphologic parameter in the diagnosis of LFS. Methods. All patients over 60 years of age were included. Data regarding the SAPA were collected from 137 patients with LFS. A total of 167 control subjects underwent lumbar magnetic resonance imaging (MRI) as part of a routine medical examination. We analyzed the cross-sectional area of the bone margin of the superior articular process at the level of L4-L5 facet joint in the axial plane. Results. The average SAPA was 96.3 ± 13.6 mm2 in the control group and 128.1 ± 17.2 mm2 in the LFS group. The LFS group was found to have significantly higher levels of SAPA (p < 0.001) in comparison to the control group. In the LFS group, the optimal cut-off value was 112.1 mm2, with 84.4% sensitivity, 83.9% specificity, and AUC of 0.94 (95% CI: 0.91–0.96). Conclusions. Higher SAPA values were associated with a higher possibility of LFS. These results are important in the evaluation of patients with LFS.

show abstract

Section: Discussionmentioning

confidence: 99%

Optimal Cut-Off Value of the Superior Articular Process Area as a Morphological Parameter to Predict Lumbar Foraminal Stenosis

Lim

Choi

Cho

et al. 2017

Pain Research and Management

View full text Add to dashboard Cite

show abstract

“…Thus, our present results may be limited. Future studies should examine the correlation between the IAPCSA and conventional quantitative radiological criteria for CLSS [26][27][28][29][30][31][32][33][34][35][36][37]. In spite of these limitations, this is the first study to document the association of IAPCSA with CLSS.…”

Section: Discussionmentioning

confidence: 92%

Usefulness of the Inferior Articular Process’s Cross-Sectional Area as a Morphological Parameter for Predicting Central Lumbar Spinal Stenosis

Lee

Lim

et al. 2020

JCM

View full text Add to dashboard Cite

Hypertrophy of facet joints is associated with a high risk of central lumbar spinal stenosis (CLSS). However, no research has reported the effect of inferior articular process hypertrophy in CLSS. We hypothesize that the inferior articular process’s cross-sectional area (IAPCSA) is larger in patients with CLSS compared to those without CLSS. Data on IAPCSA were obtained from 116 patients with CLSS. A total of 102 control subjects underwent lumbar spine magnetic resonance imaging (LS-MRI) as part of a routine medical examination. Axial T1-weighted images were obtained from the two groups. Using an imaging analysis system, we investigated the cross-sectional area of the inferior articular process. The average IAPCSA was 70.97 ± 13.02 mm2 in control subjects and 88.77 ± 18.52 mm2 in patients with CLSS. CLSS subjects had significantly greater levels of IAPCSA (p < 0.001) than controls. A receiver operating characteristic (ROC) curve was plotted to determine the validity of IAPCSA as a predictor of CLSS. The most suitable cut-off point of IAPCSA for predicting CLSS was 75.88 mm2, with a sensitivity of 71.6%, a specificity of 68.6%, and an area under the curve (AUC) of 0.78 (95% CI: 0.72–0.84). Greater IAPCSA levels were associated with a higher incidence of CLSS. These results demonstrate that IAPCSA is a useful morphological predictor in the evaluation of CLSS.

show abstract

“…Significant narrowing of the cervical foramen may present as a sharp arm or neck pain, paresthesia, numbness or tingling sensation with or without symptom spreading to the distal portion of the upper extremities. Motor symptoms such as weakness may accompany sensory symptoms in aggravated cases (8)(9)(10)(11)(12)(13)(14)(15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

Uncinate Process Area as a New Sensitive Morphological Parameter to Predict Cervical Neural Foraminal Stenosis

et al. 2019

View full text Add to dashboard Cite

Background: Hypertrophy of the uncovertebral joint has been considered as a major cause of cervical neural foraminal stenosis (CNFS). The cross-sectional area of the uncinate process is a key morphologic parameter in the identification of uncovertebral joint hypertrophy. To evaluate the connection between CNFS and the uncinate process, we devised a new morphological parameter, the uncinate process area (UPA). Objective: We hypothesized that the UPA is an important morphologic parameter in the diagnosis of CNFS. Study Design: Retrospective observational study. Setting: The single center study in Incheon, Republic of Korea. Methods: UPA data were collected from 146 patients with CNFS and 197 control subjects who underwent neck computed tomography (CT) as part of a routine medical examination. Neck CT images were obtained from all subjects. The whole cross-sectional area of the bone margin of the uncinate process was measured at the C5-6 intervertebral disc level on CT scans using a picture archiving and communications system. Results: The average UPA was 15.52 mm2 in the control group and 29.97 mm2 in the CNFS group. The CNFS group displayed significantly greater UPA levels (P < 0.001). Regarding the validity of the UPA as a predictor of CNFS, the receiver operating characteristic curve analysis revealed an optimal cut-off point for the UPA of 21.15 mm2 , with 91.8% sensitivity, 93.4% specificity, and an area under the curve of 0.972 (95% CI,0.956-0.989) in the CNFS group. Limitations: Anatomically, the UP is located on the superior lateral surfaces of the C3-7 cervical vertebral bodies. However, we focused on the C5-6 uncovertebral joint level, because many previous studies revealed C6 UP has the greatest height among UP and C5-6 uncovertebral joint hypertrophy is a primary cause of CNFS. Conclusions: The newly devised UPA is a sensitive parameter for assessing CNFS. A hypertrophied UPA is associated with an increased risk of CNFS. We think that this result will be helpful for diagnostic radiology in evaluating patients with CNFS. Institutional Review Board (IRB) approval number: IS16RISI0002 Key words: Uncinate process area, cervical neural foraminal stenosis, Uncovertebral joint hypertrophy, optimal cut-off point, cross- sectional area

show abstract

Therapeutic Effect of Epidurally Administered Lipo-Prostaglandin E1 Agonist in a Rat Spinal Stenosis Model

Cited by 12 publications

References 31 publications

Optimal Cut-Off Value of the Superior Articular Process Area as a Morphological Parameter to Predict Lumbar Foraminal Stenosis

Optimal Cut-Off Value of the Superior Articular Process Area as a Morphological Parameter to Predict Lumbar Foraminal Stenosis

Usefulness of the Inferior Articular Process’s Cross-Sectional Area as a Morphological Parameter for Predicting Central Lumbar Spinal Stenosis

Uncinate Process Area as a New Sensitive Morphological Parameter to Predict Cervical Neural Foraminal Stenosis

Contact Info

Product

Resources

About