2013
DOI: 10.3233/jad-130779
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Therapeutic Effect of Exogenous Hsp70 in Mouse Models of Alzheimer's Disease

Abstract: Brain deterioration resulting from "protein folding" diseases, such as the Alzheimer's disease (AD), is one of the leading causes of morbidity and mortality in the aging human population. Heat shock proteins (Hsps) constitute the major cellular quality control system for proteins that mitigates the pathological burden of neurotoxic protein fibrils and aggregates. However, the therapeutic effect of Hsps has not been tested in a relevant setting. Here we report the dramatic neuroprotective effect of recombinant … Show more

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Cited by 114 publications
(93 citation statements)
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“…In the present study, total neuron density was significantly higher in the cortex and CA1-CA2 areas of the hippocampus in eHsp70 treated mouse brain. This finding confirms our previous data demonstrating significantly higher neuronal density in brain regions of eHsp70-treated 5XFAD mice compared with control mice (23).…”
Section: Discussionsupporting
confidence: 93%
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“…In the present study, total neuron density was significantly higher in the cortex and CA1-CA2 areas of the hippocampus in eHsp70 treated mouse brain. This finding confirms our previous data demonstrating significantly higher neuronal density in brain regions of eHsp70-treated 5XFAD mice compared with control mice (23).…”
Section: Discussionsupporting
confidence: 93%
“…This finding correlated with diminished β-amyloid accumulation. eHsp70 treatment also protected spatial memory in both models (23).…”
Section: Discussionmentioning
confidence: 85%
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